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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Regulation and Gene Expression of Heme Synthesis Under Heavy Metal Exposure- Review

Volumen 29, Edición 2, 2010, pp. 137-158
DOI: 10.1615/JEnvironPatholToxicolOncol.v29.i2.70
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SINOPSIS

Environmental pollution of heavy metals is very abundant nowadays from industry, chemicals, old paints, and pipes or resulting from previous contaminants accumulating in the food chain. Most of the iron demands of the body are needed for heme synthesis and assembly, but iron is also required for Fe-S cluster proteins and other redox enzymes. Heme is an essential, iron-binding molecule used as a prosthetic group of hemoproteins or as a regulator in multiple cellular pathways. In this review, we focused on the effect of exposure to heavy metals, such as Pb, Ga, Cu, Kd, Hg and Al, on heme synthesis as the main iron-sequestering process of the human body. These metals compete with iron on transporters, reduce the cellular iron pool and moreover, bind to proteins, and cause physical and mental disturbances. Heavy metals mainly impair various aspects of the heme synthesis pathway: gene expression, enzyme activity, and iron integration into protoporphyrin IX. Main risk factors are described as well as effects on iron dependant processes in order to increase public awareness to the distribution of heavy metals in our close environment and the harsh consequences of exposure, even in low doses.

PALABRAS CLAVE: heme, heavy metals, iron, Pb, Ga, ALAD, PBGD
CITADO POR
  1. Kopp Ricarda S., Kumbartski Michael, Harth Volker, Brüning Thomas, Käfferlein Heiko U., Partition of metals in the maternal/fetal unit and lead-associated decreases of fetal iron and manganese: an observational biomonitoring approach, Archives of Toxicology, 86, 10, 2012. Crossref

  2. Fink-Gremmels J., Introduction to animal feed contamination, in Animal Feed Contamination, 2012. Crossref

  3. Berkovitch-Luria G., Yakobovitch S., Weitman M., Nudelman A., Rozic G., Rephaeli A., Malik Z., A multifunctional 5-aminolevulinic acid derivative induces erythroid differentiation of K562 human erythroleukemic cells, European Journal of Pharmaceutical Sciences, 47, 1, 2012. Crossref

  4. Liu Xinqin, Zheng Gang, Wu Yongxiang, Shen Xuefeng, Jing Jinfei, Yu Tao, Song Han, Chen Jingyuan, Luo Wenjing, Lead exposure results in hearing loss and disruption of the cochlear blood–labyrinth barrier and the protective role of iron supplement, NeuroToxicology, 39, 2013. Crossref

  5. Hennig Georg, Gruber Christian, Vogeser Michael, Stepp Herbert, Dittmar Stephan, Sroka Ronald, Brittenham Gary M., Dual-wavelength excitation for fluorescence-based quantification of zinc protoporphyrin IX and protoporphyrin IX in whole blood, Journal of Biophotonics, 7, 7, 2014. Crossref

  6. Trinchella Francesca, Esposito Maria Grazia, Simoniello Palma, Scudiero Rosaria, Cadmium, lead and metallothionein contents in cultivated mussels (Mytilus galloprovincialis) from the Gulf of Naples (Southern Italy), Aquaculture Research, 44, 7, 2013. Crossref

  7. Floyd C. Jordan, Malaiyandi Latha M., Dineley Kirk E., Detecting zinc and cadmium with fura ratiometric probes, BIOS, 84, 2, 2013. Crossref

  8. Davenport Andrew, Trace Elements in Patients with Chronic Kidney Disease, in Chronic Renal Disease, 2015. Crossref

  9. Zamir Rausan, Hosen Anowar, Ullah M. Obayed, Nahar Nilufar, Microbial and Heavy Metal Contaminant of Antidiabetic Herbal Preparations Formulated in Bangladesh, Evidence-Based Complementary and Alternative Medicine, 2015, 2015. Crossref

  10. Seddik Leila, Madjou Bah Thierno, Aoues Abdelkader, Slimani Miloud, Benderdour Mohamed, Elucidation of mechanisms underlying the protective effects of olive leaf extract against lead-induced neurotoxicity in Wistar rats, The Journal of Toxicological Sciences, 36, 6, 2011. Crossref

  11. Rogers Jack T., Venkataramani Vivek, Washburn Cecilia, Liu Yanyan, Tummala Vinusha, Jiang Hong, Smith Ann, Cahill Catherine M., A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity, Journal of Neurochemistry, 138, 3, 2016. Crossref

  12. Bernhoft Robin A., Cadmium Toxicity and Treatment, The Scientific World Journal, 2013, 2013. Crossref

  13. Chatterjee Sreoshi, Saxena Rajiv K., Mezey Eva, Preferential Elimination of Older Erythrocytes in Circulation and Depressed Bone Marrow Erythropoietic Activity Contribute to Cadmium Induced Anemia in Mice, PLOS ONE, 10, 7, 2015. Crossref

  14. Elkhadragy Manal F., Al-Olayan Ebtesam M., Al-Amiery Ahmed A., Abdel Moneim Ahmed E., Protective Effects of Fragaria ananassa Extract Against Cadmium Chloride-Induced Acute Renal Toxicity in Rats, Biological Trace Element Research, 181, 2, 2018. Crossref

  15. Izrael-Živković Lidija, Rikalović Milena, Gojgić-Cvijović Gordana, Kazazić Saša, Vrvić Miroslav, Brčeski Ilija, Beškoski Vladimir, Lončarević Branka, Gopčević Kristina, Karadžić Ivanka, Cadmium specific proteomic responses of a highly resistantPseudomonas aeruginosasan ai, RSC Advances, 8, 19, 2018. Crossref

  16. Ke Yixin, Yu Kaihang, Zeng Weiliang, Lian Guojun, Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats, Acta Cirurgica Brasileira, 34, 7, 2019. Crossref

  17. Davenport Andrew, Trace Elements in Chronic Kidney Disease, in Chronic Renal Disease, 2020. Crossref

  18. Suljević Damir, Hodžić-Klapuh Lejla, Handžić Nejira, Fočak Muhamed, Morpho-functional alterations in lymphocytes and erythrocytes of Japanese quail due to prolonged in vivo exposure to heavy metal complexes, Journal of Trace Elements in Medicine and Biology, 59, 2020. Crossref

  19. Oyeyemi Ajibade O., Oseni Olatunde A., Molehin Olorunfemi R., Babatunde Adebimpe O., Influence of Polyalthia longifolia (Sonn) leaves on oxidative stress biomarkers in the kidney of cadmium-induced toxicity rats, Comparative Clinical Pathology, 29, 2, 2020. Crossref

  20. Hanna David A., Hu Rebecca, Kim Hyojung, Martinez-Guzman Osiris, Torres Matthew P., Reddi Amit R., Heme bioavailability and signaling in response to stress in yeast cells, Journal of Biological Chemistry, 293, 32, 2018. Crossref

  21. Akinwumi Kazeem.A., Osifeso O.O., Jubril Afusat J., Omirinde Jamiu, Aboyewa Jumoke A., Alteration of hematological profile and nephro-testicular damage in rats exposed to coatings of mobile charge cards, Scientific African, 13, 2021. Crossref

  22. Wang Pengcheng, Sachar Madhav, Lu Jie, Shehu Amina I., Zhu Junjie, Chen Jing, Liu Ke, Anderson Karl E., Xie Wen, Gonzalez Frank J., Klaassen Curtis D., Ma Xiaochao, The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria, Science Advances, 5, 9, 2019. Crossref

  23. de Andrade Vanda Lopes, Cota Madalena, Serrazina Daniela, Mateus Maria Luisa, Aschner Michael, dos Santos Ana Paula Marreilha, Metal environmental contamination within different human exposure context- specific and non-specific biomarkers, Toxicology Letters, 324, 2020. Crossref

  24. Lopes de Andrade V., Serrazina D., Mateus M.L., Batoréu C., Aschner M., Marreilha dos Santos A.P., Multibiomarker approach to assess the magnitude of occupational exposure and effects induced by a mixture of metals, Toxicology and Applied Pharmacology, 429, 2021. Crossref

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