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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Anti-Inflammatory and Apoptotic Signaling Effect of Fucoxanthin on Benzo(A)Pyrene-Induced Lung Cancer in Mice

Volumen 38, Edición 3, 2019, pp. 239-251
DOI: 10.1615/JEnvironPatholToxicolOncol.2019030301
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SINOPSIS

Fucoxanthin, a potent carotenoid present in various natural sources especially from seaweeds; it exhibits several biological effects like anti-neoplastic, anti-mutagenic, anti-diabetic, anti-obesity and anti-inflammatory actions. Fucoxanthin role in chemoprevention of lung cancer in mouse model induced using benzo(a)pyrene [B(a)P] has been presented here. Oral administration of fucoxanthin with and without B(a)P were studied, the results from our study shows that fucoxanthin significantly decreased tumor progression in mice exposed to B(a)P, the obtained data were correlated with increased antioxidant, apoptosis and decreased tumour marker and anti-apoptotic molecules. With respect to apoptosis, fucoxanthin treated animals shows increased apoptosis compared to tumor induced mice by increased expression of caspase 9 and 3 and decreased expression of anti-apoptotic Bcl2 protein. Finally, histopathological and immuno histochemical analysis also revealed that fucoxanthin shows potent anticancer agent by bringing back the damaged tissue treated with B(a)P and also decreases the expression of PCNA in cancer induced mice. The anticancer effect of fucoxanthin may be attributed by several independent mechanisms which play a important roles in the prevention of cancer development, there is also substantial evidences to show that fucoxanthin acts indirectly by increasing the antioxidant capacity of affected tissue and prepared to cope up with oxidative stress which is proved in our study. Thus from our study it is clearly established that fucoxanthin act as a persuasive anticancer drug against lung cancer.

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CITADO POR
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  2. Koklesova Lenka, Liskova Alena, Samec Marek, Buhrmann Constanze, Samuel Samson Mathews, Varghese Elizabeth, Ashrafizadeh Milad, Najafi Masoud, Shakibaei Mehdi, Büsselberg Dietrich, Giordano Frank A., Golubnitschaja Olga, Kubatka Peter, Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back, Cancers, 12, 9, 2020. Crossref

  3. Lykov Alexander, Rachkovsky Edmund, Gevorgiz Ruslan, Zheleznova Svetlana, Kotlyarova Anastasiya, Toxicity of Fucoxanthin on Balb/c Mice Splenocytes and Thymocytes, 2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB), 2020. Crossref

  4. Chen Shiu-Jau, Lin Tzer-Bin, Peng Hsien-Yu, Liu Hsiang-Jui, Lee An-Sheng, Lin Cheng-Hsien, Tseng Kuang-Wen, Cytoprotective Potential of Fucoxanthin in Oxidative Stress-Induced Age-Related Macular Degeneration and Retinal Pigment Epithelial Cell Senescence In Vivo and In Vitro, Marine Drugs, 19, 2, 2021. Crossref

  5. Li Shenrui, Zheng Xiaoyun, Fang Qingshu, Gong Yifu, Wang Heyu, Exploring the potential of photosynthetic induction factor for the commercial production of fucoxanthin in Phaeodactylum tricornutum, Bioprocess and Biosystems Engineering, 44, 8, 2021. Crossref

  6. Wu Shi, Pang Yaobin, He Yingjie, Zhang Xiaotong, Peng Li, Guo Jing, Zeng Jinhao, A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds, Biomedicine & Pharmacotherapy, 140, 2021. Crossref

  7. Ávila-Román Javier, García-Gil Sara, Rodríguez-Luna Azahara, Motilva Virginia, Talero Elena, Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids, Marine Drugs, 19, 10, 2021. Crossref

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  10. Ming Jia Xiong, Wang Zhao Cong, Huang Yi, Ohishi Hifumi, Wu Rong Ji, Shao Yan, Wang Hui, Qin Ming Yang, Wu Ze Liang, Li Yi Yong, Chang Zhou Shun, Chen Hui, Liu Hui, Xu Rong, Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib, Journal of Ethnopharmacology, 265, 2021. Crossref

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