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Photosensitized Inactivation of Protozoa Pathogenic Agents of Water- and Vector-Borne Diseases

Volumen 2, Edición 3, 2011, pp. 247-254
DOI: 10.1615/ForumImmunDisTher.2011004382
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SINOPSIS

Several protozoa are recognized etiological agents of dangerous water- and vector-borne diseases, and some of them are among the most dangerous and deadly of human pathogens. Diseases such as amoebiasis, leishmaniasis, trypanosomiasis, and malaria are among the most fatal infections for humans. Despite major advances in medicine in the last century, infectious diseases continue to present enormous global health problems. Antibiotic therapy for the infections caused by pathogenic protozoa is generally empirical, and patient recovery is often problematic, but some forms of combination therapy have proven more successful than single-drug therapies. New approaches that are effective, affordable, and widely applicable and that are not susceptible to resistance are urgently needed. The effectiveness of antimicrobial photodynamic therapy (PDT) as a novel mode of treating some diseases caused by eukaryotic microorganisms has been demonstrated against some protozoan pathogenic species. PDTs offer alternative approaches in the medical and environmental control of pathogenic agents as well as the sterilization of blood products.

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