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Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Genetically Engineered Natural Killer Cells as a Means for Adoptive Tumor Immunotherapy

Volumen 36, Edición 4, 2016, pp. 329-347
DOI: 10.1615/CritRevImmunol.2017019376
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SINOPSIS

Natural killer (NK) cells are lymphoid cells of the innate immune system; they stand at the first defense line against viruses and transformed cells. NK cells use an array of germline-encoded activating and inhibitory receptors that sense virus-infected cells or malignant cells displaying altered surface expression of activating and inhibitory NK cell ligands. They exert potent cytotoxic responses to cellular targets and thus are candidate effector cells for immunotherapy of cancer. In particular, the genetic engineering of NK cells with chimeric antigen receptors (CARs) against surface-expressed tumor-associated antigens (TAAs) seems promising. In the allogeneic context, gene-modified NK cells compared to T cells may be superior because they are short-lived effector cells and do not cause graft-versus-host disease. Furthermore, their anti-tumoral activity can be augmented by combinatorial use with therapeutic antibodies, chemotherapeutics, and radiation. Today, efforts are being undertaken for large-scale NK-cell expansion and their genetic engineering for adoptive cell transfer. With the recent advances in understanding the complex biological interactions that regulate NK cells, it is expected that the genetic engineering of NK cells and a combinatorial blockade of immune evasion mechanisms are required to exploit the full potential of NK-cell-based immunotherapies.

CITADO POR
  1. Matosevic Sandro, Viral and Nonviral Engineering of Natural Killer Cells as Emerging Adoptive Cancer Immunotherapies, Journal of Immunology Research, 2018, 2018. Crossref

  2. Varani , Auletta , Signore , Galli , State of the Art of Natural Killer Cell Imaging: A Systematic Review, Cancers, 11, 7, 2019. Crossref

  3. Agrawal Vaibhav, Gbolahan Olumide B., Stahl Maximilian, Zeidan Amer M., Zaid Mohammad Abu, Farag Sherif S., Konig Heiko, Vaccine and Cell-based Therapeutic Approaches in Acute Myeloid Leukemia, Current Cancer Drug Targets, 20, 7, 2020. Crossref

  4. Yilmaz Ahmet, Cui Hanwei, Caligiuri Michael A., Yu Jianhua, Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy, Journal of Hematology & Oncology, 13, 1, 2020. Crossref

  5. Lupo Kyle, Matosevic Sandro, Immunometabolic targeting of NK cells to solid tumors, in Successes and Challenges of NK Immunotherapy, 2021. Crossref

  6. Shokouhifar Alireza, Firouzi Javad, Nouri Masoumeh, Sarab Gholamreza Anani, Ebrahimi Marzieh, NK cell upraise in the dark world of cancer stem cells, Cancer Cell International, 21, 1, 2021. Crossref

  7. Murad Shafiq, Michen Susanne, Becker Alexander, Füssel Monika, Schackert Gabriele, Tonn Torsten, Momburg Frank, Temme Achim, NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme, International Journal of Molecular Sciences, 23, 10, 2022. Crossref

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