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Critical Reviews™ in Immunology
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ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2016017164
pages 75-98

Metabolic Factors that Contribute to Lupus Pathogenesis

Wei Li
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610; Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory, Beijing Normal University, Beijing 100875, People's Republic of China
Ramya Sivakumar
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610
Anton A. Titov
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610
Seung-Chul Choi
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610
Laurence Morel
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610

SINOPSIS

Systemic lupus erythematosus (SLE) is an autoimmune disease in which organ damage is mediated by pathogenic autoantibodies directed against nucleic acids and protein complexes. Studies in SLE patients and in mouse models of lupus have implicated virtually every cell type in the immune system in the induction or amplification of the autoimmune response as well as the promotion of an inflammatory environment that aggravates tissue injury. Here, we review the contribution of CD4+ T cells, B cells, and myeloid cells to lupus pathogenesis and then discuss alterations in the metabolism of these cells that may contribute to disease, given the recent advances in the field of immunometabolism.


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