Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.404 Factor de Impacto de 5 años: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v27.i1.30
pages 33-46

Autoimmune Etiology in Chronic Prostatitis Syndrome: An Advance in the Understanding of This Pathology

Virginia Elena Rivero
Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre, Medina Allende, Ciudad Universitaria, Cordoba, Argentina
Ruben Dario Motrich
Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre, Medina Allende, Ciudad Universitaria, Cordoba, Argentina
Mariana Maccioni
Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre, Medina Allende, Ciudad Universitaria, Cordoba, Argentina
Clelia Maria Riera
Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre, Medina Allende, Ciudad Universitaria, Cordoba, Argentina

SINOPSIS

The prostate is the target of many inflammatory and neoplastic disorders that affect men of all ages. Pathological conditions of the prostate gland range from infection of this organ by ascending bacteria from infected urine, to chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) of a still unknown etiology (accompanied with inflammation and lymphocyte infiltration of the gland), to benign hyperplasia and cancer. Patients under 50 years of age usually suffer from CP/CPPS, a chronic inflammatory syndrome characterized by pelvic pain, irritative voiding symptoms, and sexual dysfunction complaints.
In this review, we summarize the current knowledge regarding immunological alterations present in CP/ CPPS patients. Remarkably, an inflammation state, in the absence of an invading infectious agent, is established in these patients, suggesting that an autoimmune process could be involved. In fact, specific autoimmune response to prostate antigens has recently been reported in CP/CPPS patients. Autoimmune response to prostate gland affects the seminal quality reported in these patients and may have critical consequences in their fertility. It is anticipated that preclinical studies in experimental models for CP/CPSS will provide important insights into the etiopathogenic mechanisms involved in this disease. We discuss here the similarities and the differences between human disease and experimental models and argue for the importance of the prostate gland in male reproductive function. Ultimately, we suggest that a state of inflammation, originally incited by an autoimmune response within the prostate, together with a diminished prostate functionality, may compromise male fertility.


Articles with similar content:

Defining Early Life Stress as a Precursor for Autoimmune Disease
Critical Reviews™ in Immunology, Vol.39, 2019, issue 5
Jamie Y. Choe, Maya Nair, Riyaz Basha, Harlan P. Jones, Byung-Jin Kim
IL-7 and Its Beneficial Role in Sepsis-Induced T Lymphocyte Dysfunction
Critical Reviews™ in Immunology, Vol.38, 2018, issue 6
Fabienne Venet, Charles de Roquetaillade, Guillaume Monneret, Morgane Gossez
Eosinophils in Homeostasis and Their Contrasting Roles during Inflammation and Helminth Infections
Critical Reviews™ in Immunology, Vol.36, 2016, issue 3
Julia Strandmark, Susanne Hartmann, Sebastian Rausch
Structure of IL-10 and Its Role in Autoimmune Exocrinopathy
Critical Reviews™ in Immunology, Vol.20, 2000, issue 2
Ichiro Saito
A Critical Review of Ankylosing Spondylitis
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.10, 1998, issue 3
Nicola H. Ryall , P. Helliwell