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Critical Reviews™ in Immunology
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ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2014010694
pages 315-345

Transcriptional Regulation of IL-10 and Its Cell-Specific Role In Vivo

Kirsty F. MacKenzie
Division of Cell Signaling and Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom
Michael J. Pattison
Division of Cell Signaling and Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom
J. Simon C. Arthur
Division of Cell Signaling and Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom


IL-10 is an important anti-inflammatory cytokine that plays important roles in controlling inflammatory responses and keeping the immune system in check following activation. Loss of IL-10 function in mice or humans results in the development of inflammatory bowel disease in response to an elevated immune response to the gut flora. IL-10 also acts to prevent excessive inflammation during the course of infection and has been implicated in a variety of autoimmune conditions. In response to inflammatory signals, IL-10 can be produced by a number of immune cells including T cells, B cells, macrophages, and dendritic cells. Distinct mechanisms control the production of IL-10 in these different cells types. In this review, we describe recent studies that have looked at the signaling pathways that regulate IL-10 production in these cells. Given the number of cell types that produce IL-10, it is perhaps not surprising that the in vivo source of IL-10 can vary in different immune models. We also describe how work using conditional IL-10 knockout mice or adoptive transfer of IL-10−deficient cells has begun to further our understanding regarding which specific immune cells are required for IL-10 production in vivo under different conditions.

PALABRAS CLAVE: interleukin-10, B10, Tr1, macrophage, CREB, STAT3

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