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Critical Reviews™ in Immunology
Factor de Impacto: 1.352 Factor de Impacto de 5 años: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v18.i3.20
pages 185-220

IL-2-lnduced Cellular Events

Javier Gomez
Department of Immunology and Oncology, Centra Nacional de Biotecnologia, Universidad Autonoma, Campus de Cantoblanco, E-28049, Madrid, Spain
Ana Gonzalez
Department of Immunology and Oncology, Centra Nacional de Biotecnologia, Universidad Autonoma, Campus de Cantoblanco, E-28049, Madrid, Spain
Carlos Martinez-A.
Department of Immunology and Oncology, Centra Nacional de Biotecnologia, Universidad Autonoma, Campus de Cantoblanco, E-28049, Madrid, Spain
Angelita Rebollo
Department of Immunology and Oncology, Centra Nacional de Biotecnologia, Universidad Autonoma, Campus de Cantoblanco, E-28049, Madrid, Spain

SINOPSIS

In this review we discuss several molecules that are attractive candidates as transducing molecules involved in signaling processes. IL-2 receptor signaling is a complex process involving a large number of molecules: Ras, Rho, PI3 kinase, PKC, Akt, transcription factors NF-AT, and NF-kB and some target genes such as bcl-2, c-myc, c-jun and c-fos. Ras and Rho have been defined as dual molecules because Ras- and Rho-initiated signals can either promote or inhibit apoptosis.
Several studies have contributed to the delineation of a signaling pathway structured in three independent channels designated channels 1, 2, and 3. These three channels serve as major landmarks: Lck-c-fos/c-jun (channel 1), Syk-myc (channel 2), and a pathway leading to actin organization/bcl-2 expression (channel 3). The detailed hierarchical organization of these three channels is presented throughout the review and the model is depicted in the figure.


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