Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
Origins of Adaptive Immunity
SINOPSIS
Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, which stresses the importance of coincident whole-genome duplications. Through a close examination of the key molecules and molecular processes underpinning adaptive immunity, this review suggests a less-extreme model, in which adaptive immunity emerged as part of longer evolutionary journey. Clearly, whole-genome duplications provided additional raw genetic materials that were vital to the emergence of adaptive immunity, but a variety of other genetic events were also required to generate some of the key molecules, whereas others were preexisting and simply co-opted into adaptive immunity.
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Liongue Clifford, Ward Alister C., Evolution of the JAK-STAT pathway, JAK-STAT, 2, 1, 2013. Crossref
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John Liza B., Ward Alister C., The Ikaros gene family: Transcriptional regulators of hematopoiesis and immunity, Molecular Immunology, 48, 9-10, 2011. Crossref
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Liongue Clifford, Sertori Robert, Ward Alister C., Evolution of Cytokine Receptor Signaling, The Journal of Immunology, 197, 1, 2016. Crossref
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Brown Karen E., The Continuing Flight of Ikaros, in The Functional Nucleus, 2016. Crossref
-
Liongue Clifford, O'Sullivan Lynda A., Trengove Monique C., Ward Alister C., Singh Shree Ram, Evolution of JAK-STAT Pathway Components: Mechanisms and Role in Immune System Development, PLoS ONE, 7, 3, 2012. Crossref
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Chang Shun-Hsien, Wu Guan-James, Wu Chien-Hui, Huang Chung-Hsiung, Tsai Guo-Jane, Oral administration with chitosan hydrolytic products modulates mitogen-induced and antigen-specific immune responses in BALB/c mice, International Journal of Biological Macromolecules, 131, 2019. Crossref
-
Hurley W. L., Theil P. K., Immunoglobulins in Mammary Secretions, in Advanced Dairy Chemistry, 2013. Crossref
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Keselowsky Benjamin George, Acharya Abhinav, Lewis Jamal S., Innate and Adaptive Immunity, in Biomaterials Science, 2020. Crossref