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Critical Reviews™ in Immunology
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ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v17.i2.10
pages 119-137

Mechanisms of Oral Tolerance

Paul Garside
Department of Immunology, University of Glasgow, Western Infirmary, Glasgow, G11 6NT
Allan Mcl Mowat
Department of Immunology, University of Glasgow, Western Infirmary, Glasgow, G11 6NT

SINOPSIS

Oral tolerance is the specific immunological unresponsiveness induced by feeding antigen. Although it is an obstacle to oral vaccination, it is probably the mechanism that prevents intestinal hypersensitivity reactions to food antigens and may provide a novel strategy for the treatment of a range of inflammatory disorders. Feeding antigen can provide stable and long-lasting tolerance of a wide range of immune responses to a variety of antigens. However, the mechanisms of oral tolerance and the major factors that influence them remain controversial.


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