Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.352 Factor de Impacto de 5 años: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumes:
Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v19.i2.40
18 pages

Th1 and Th2 Cytokines in Organ Transplantation: Paradigm Lost?

Ronald W. Busuttil
Ftafik M. Ghobrial
Jerzy W. Kupiec-Weglinski
The Dumont-UCLA Transplant Center, University of California School of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095
Yuan Zhai

SINOPSIS

Identification of CD4+ T helper lymphocyte subsets that exhibit distinct cytokine elaboration patterns has provided a valuable framework for understanding the heterogeneity of the immune response. Much progress has been made in recent years in defining the cellular and molecular mechanisms by which cytokines induce T cell differentiation. In transplantation models, the Thl cytokine profile often associates with allograft rejection, while the Th2 profile favors the acquisition of tolerance. However, this paradigm may not be sufficient to explain the recently demonstrated in vivo effects of cytokine manipulation on allograft survival. Th2 cytokines may not be necessary for tolerance induction, while Thl cytokines may even be beneficial in promoting allograft survival. However, such data should be interpreted in light of the diverse and often redundant effects displayed by cytokine networks in vivo. Understanding the complex interactions of cytokines in the alloimmune cascade therefore is critical for designing therapeutic strategies that abrogate allograft rejection and induce donor-specific tolerance, an elusive goal in organ transplantation.


Articles with similar content:

Regulatory Mechanism of The Induction of Regulatory T Cells through Growth Factors Released by Human Mesenchymal Stem Cells
Critical Reviews™ in Immunology, Vol.38, 2018, issue 6
Yoshiya Tanaka, Masahiro Kondo, Shingo Nakayamada, Ippei Miyagawa
T Lymphocytes and Their Cytokines in Human Immunodeficiency Virus (HIV) Infection: Implications for Associated Neoplasias
Critical Reviews™ in Oncogenesis, Vol.6, 1995, issue 3-6
Christian Jassoy, Bruce D. Walker
The Impact of Extracellular Acidosis on Dendritic Cell Function
Critical Reviews™ in Immunology, Vol.24, 2004, issue 5
Romina Gamberale, Juan Sabatte, Jorge Raul Geffner, Mirta Giordano, Monica Elba Vermeulen, Ana Ceballos, Diego Martinez, Analia Silvina Trevani
Quantitating Therapeutically Relevant T-Cell Responses to Cancer Vaccines
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
H. Kim Lyerly, Michael A. Morse, Timothy M. Clay, Paul J. Mosca, Amy C. Hobeika
Human Leukemia-derived Dendritic Cells: Ex-vivo Development of Specific Antileukemic Cytotoxicity
Critical Reviews™ in Immunology, Vol.18, 1998, issue 1-2
Dominique Charron, Richard E. Champlin, Aniruddha Choudhury, David F. Claxton, Antoine Toubert, Sapna Sutaria