Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.352 Factor de Impacto de 5 años: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumes:
Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v19.i2.30
27 pages

Transcriptional Regulation in B Cell Differentiation

David Liberg
Mikael Sigvardsson
Department of Cellular and Molecular Biology, Immunology Group, Lund University, Sweden

SINOPSIS

B cell development is a multistage differentiation process that ultimately generates antibody-secreting plasma cells. This model developmental pathway is governed by a choreographed pattern of expression from genes encoding stage and lineage-specific proteins. This is achieved by the interaction of distinct transcription factors with regulatory elements, placing these proteins in a central position in B cell ontogeny. The importance of distinct transcription factors is also supported by the notion that B cell development is disrupted in mice bearing homozygous null alleles of certain factors involved in the control of B-cell-specific genes. In this review we compare and contrast the transcriptional regulation of well-studied B lymphoid restricted genes, on a gene by gene basis, focusing on the functional structure of transcription control regions and interacting transcription factors.


Articles with similar content:

Retinoid-Regulated Gene Expression in Neural Development
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 4
Margaret Clagett-Dame, Lori A. Plum
Sp1 Control of Gene Expression in Myeloid Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 3
Karen K. Resendes, Alan G. Rosmarin
Histone Deacetylase Co-Repressor Complex Control of Runx2 and Bone Formation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 3
Aswathy K. Nair, Eric D. Jensen, Jennifer J. Westendorf
Ikaros and Tumor Suppression in Acute Lymphoblastic Leukemia
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 1-2
Sinisa Dovat, Kimberly J. Payne
Regulation and Regulatory Role of the Retinoids
Critical Reviews™ in Eukaryotic Gene Expression, Vol.5, 1995, issue 3-4
Shehnaaz Manji, T. John Martin, Hong Zhou, Kong Wan Ng