Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
Critical Roles of Toll-Like Receptors in Host Defense
SINOPSIS
Drosophila Toll is involved not only in dorsoventral patterning of embryos but also in immune responses to microbial infection. Several Toll-like receptors (TLRs) have also been identified in mammals. They are expressed on macrophages or dendritic cells (DCs), which are essential sentinels for innate immunity. These cells utilize TLRs as a recognition and signal transducing receptor for microbial molecular components. The most characterized mammalian TLR, TLR4, is a receptor for lipopolysaccharides (LPS). TLR2 recognizes other components, such as peptideglycans (PGN). This recognition, called pattern recognition, is essential for the establishment of innate immunity, which is the basis for host defense. In this article, we review recent findings about this expanding receptor family.
-
Nagano F., Kaneko T., Yoshinaga Y., Ukai T., Kuramoto A., Nakatsu S., Oshino K., Ichimura I., Hara Y., Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction, Journal of Periodontal Research, 48, 4, 2013. Crossref
-
Im Seung-Soon, Yousef Leyla, Blaschitz Christoph, Liu Janet Z., Edwards Robert A., Young Stephen G., Raffatellu Manuela, Osborne Timothy F., Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1a, Cell Metabolism, 13, 5, 2011. Crossref
-
Aleyas Abi G., Han Young Woo, Patil Ajit Mahadev, Kim Seong Bum, Kim Koanhoi, Eo Seong Kug, Impaired cross-presentation of CD8α+CD11c+dendritic cells by Japanese encephalitis virus in a TLR2/MyD88 signal pathway-dependent manner, European Journal of Immunology, 42, 10, 2012. Crossref
-
Mori Y., Yoshimura A., Ukai T., Lien E., Espevik T., Hara Y., Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis, Oral Microbiology and Immunology, 18, 1, 2003. Crossref
-
Cutler Christopher W., Jotwani Ravi, Antigen-presentation and the role of dendritic cells in periodontitis, Periodontology 2000, 35, 1, 2004. Crossref
-
Deehan Maureen R., Goodridge Helen S., Blair Derek, Lochnit Gunter, Dennis Roger D., Geyer Rudolf, Harnett Margaret M., Harnett William, Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effects, Parasite Immunology, 24, 9-10, 2002. Crossref
-
Koutouzis Theofilos, Catania Dominick, Neiva Kathleen, Wallet Shannon M., Innate Immune Receptor Expression in Peri-Implant Tissues of Patients With Different Susceptibility to Periodontal Diseases, Journal of Periodontology, 84, 2, 2013. Crossref
-
Guirado Evelyn, Schlesinger Larry S., Kaplan Gilla, Macrophages in tuberculosis: friend or foe, Seminars in Immunopathology, 35, 5, 2013. Crossref
-
Heine Holger, TLRs, NLRs and RLRs: Innate sensors and their impact on allergic diseases – A current view, Immunology Letters, 139, 1-2, 2011. Crossref
-
de Vries I. Jolanda M., Tel Jurjen, Benitez-Ribas Daniel, Torensma Ruurd, Figdor Carl G., Prophylactic vaccines mimic synthetic CpG oligonucleotides in their ability to modulate immune responses, Molecular Immunology, 48, 6-7, 2011. Crossref
-
Kadowaki Takeshi, Yasui Yasumasa, Nishimiya Osamu, Takahashi Yukinori, Kohchi Chie, Soma Gen-Ichiro, Inagawa Hiroyuki, Orally administered LPS enhances head kidney macrophage activation with down-regulation of IL-6 in common carp (Cyprinus carpio), Fish & Shellfish Immunology, 34, 6, 2013. Crossref
-
Barr Tom A., Brown Sheila, Ryan Gemma, Zhao Jiexin, Gray David, TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells, European Journal of Immunology, 37, 11, 2007. Crossref
-
Muriel Pablo, NF-κB in liver diseases: a target for drug therapy, Journal of Applied Toxicology, 29, 2, 2009. Crossref
-
Yamamoto Masato, Curiel David T, Current Issues and Future Directions of Oncolytic Adenoviruses, Molecular Therapy, 18, 2, 2010. Crossref
-
Hoth J. Jason, Hudson William P., Brownlee Noel A., Yoza Barbara K., Hiltbold Elizabeth M., Meredith J. Wayne, McCall Charles E., TOLL-LIKE RECEPTOR 2 PARTICIPATES IN THE RESPONSE TO LUNG INJURY IN A MURINE MODEL OF PULMONARY CONTUSION, Shock, 28, 4, 2007. Crossref
-
Sathe Ameya, Patgaonkar Mandar S., Bashir Tahir, Reddy Kudumula Venkata Rami, MicroRNA Let-7f: A Novel Regulator of Innate Immune Response in Human Endocervical Cells, American Journal of Reproductive Immunology, 71, 2, 2014. Crossref
-
Eskan Mehmet A., Rose Beate G., Benakanakere Manjunatha R., Zeng Qun, Fujioka Daisuke, Martin Michael H., Lee Menq-Jer, Kinane Denis F., TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells, European Journal of Immunology, 38, 4, 2008. Crossref
-
Baranov Maksim V, Beest Martin ter, Bogaart Geert van den, Reaching for far-flung antigen: How solid-core podosomes of dendritic cells transform into protrusive structures, Communicative & Integrative Biology, 7, 5, 2014. Crossref
-
Gröbner Sabine, Lukowski Robert, Autenrieth Ingo B., Ruth Peter, Lipopolysaccharide induces cell volume increase and migration of dendritic cells, Microbiology and Immunology, 58, 1, 2014. Crossref
-
Horiuchi Yasuhiro, Bae SangJae, Katayama Ichiro, Oshikawa Tetsuya, Okamoto Masato, Sato Mitsunobu, Lipoteichoic acid-related molecule derived from the streptococcal preparation, OK-432, which suppresses atopic dermatitis-like lesions in NC/Nga mice, Archives of Dermatological Research, 298, 4, 2006. Crossref
-
ZHANG Q., FENG X., NIE W., GOLENBOCK D. T., MAYANJA-KIZZA H., TZIPORI S., FENG H., MyD88-dependent pathway is essential for the innate immunity to Enterocytozoon bieneusi, Parasite Immunology, 33, 4, 2011. Crossref
-
Ren Chunhua, Chen Ting, Jiang Xiao, Wang Yanhong, Hu Chaoqun, Identification and functional characterization of a novel ferritin subunit from the tropical sea cucumber, Stichopus monotuberculatus, Fish & Shellfish Immunology, 38, 1, 2014. Crossref
-
Amcheslavsky Alla, Hemmi Hiroaki, Akira Shizuo, Bar-Shavit Zvi, Differential Contribution of Osteoclast- and Osteoblast-Lineage Cells to CpG-Oligodeoxynucleotide (CpG-ODN) Modulation of Osteoclastogenesis, Journal of Bone and Mineral Research, 20, 9, 2005. Crossref
-
Ren Chunhua, Chen Ting, Jiang Xiao, Luo Xing, Wang Yanhong, Hu Chaoqun, The first echinoderm gamma-interferon-inducible lysosomal thiol reductase (GILT) identified from sea cucumber (Stichopus monotuberculatus), Fish & Shellfish Immunology, 42, 1, 2015. Crossref
-
Wachi Takanori, Shuto Takahiro, Shinohara Yoshinori, Matono Yoshinari, Makihira Seicho, Release of titanium ions from an implant surface and their effect on cytokine production related to alveolar bone resorption, Toxicology, 327, 2015. Crossref
-
Huang Hao, Park Cheol Kyu, Ryu Ji Yoon, Chang Eun-Ju, Lee Youngkyun, Kang Sam Sik, Kim Hong-Hee, Expression profiling of lipopolysaccharide target genes in RAW264.7 cells by oligonucleotide microarray analyses, Archives of Pharmacal Research, 29, 10, 2006. Crossref
-
Murata Yukie, Amao Michiko, Yoneda Junya, Hamuro Junji, Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging, Molecular Immunology, 38, 10, 2002. Crossref
-
Quan Song-Hua, Zhang Yu-Lian, Han Doo Hee, Iwakura Yoichiro, Rhee Chae-Seo, Contribution of interleukin 17A to the development and regulation of allergic inflammation in a murine allergic rhinitis model, Annals of Allergy, Asthma & Immunology, 108, 5, 2012. Crossref
-
Pannacci Marilou, Lucini Valeria, Colleoni Federica, Martucci Cataldo, Grosso Silvia, Sacerdote Paola, Scaglione Francesco, Panax ginseng C.A. Mayer G115 modulates pro-inflammatory cytokine production in mice throughout the increase of macrophage toll-like receptor 4 expression during physical stress, Brain, Behavior, and Immunity, 20, 6, 2006. Crossref
-
Murata Yukie, Shimamura Toshiro, Tagami Tomoyuki, Takatsuki Fumihiko, Hamuro Junji, The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content, International Immunopharmacology, 2, 5, 2002. Crossref
-
Delvecchio Francesca Romana, Vadrucci Elisa, Cavalcanti Elisabetta, De Santis Stefania, Kunde Dale, Vacca Michele, Myers Jay, Allen Frederick, Bianco Giusy, Huang Alex Y., Monsurro Vladia, Santino Angelo, Chieppa Marcello, Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturational profile, European Journal of Immunology, 45, 9, 2015. Crossref
-
Wang Jun, Zhao Hui, Mao-Ying Qi-Liang, Cao Xiao-Ding, Wang Yan-Qing, Wu Gen-Cheng, Electroacupuncture downregulates TLR2/4 and pro-inflammatory cytokine expression after surgical trauma stress without adrenal glands involvement, Brain Research Bulletin, 80, 1-2, 2009. Crossref
-
Gabehart Kelsa, Correll Kelly A., Loader Joan E., White Carl W., Dakhama Azzeddine, The lung response to ozone is determined by age and is partially dependent on toll-Like receptor 4, Respiratory Research, 16, 1, 2015. Crossref
-
Weeratna Risini D., Makinen Shawn R., McCluskie Michael J., Davis Heather L., TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848), Vaccine, 23, 45, 2005. Crossref
-
Kimura Tomomi, Shibata Yoko, Yamauchi Keiko, Igarashi Akira, Inoue Sumito, Abe Shuichi, Fujita Kazuhiro, Uosaki Yoichi, Kubota Isao, Oxidized Phospholipid, 1-Palmitoyl-2-(9′-Oxo-Nonanoyl)-Glycerophosphocholine (PON-GPC), Produced in the Lung Due to Cigarette Smoking, Impairs Immune Function in Macrophages, Lung, 190, 2, 2012. Crossref
-
Park Mi-Young, Carnosic acid disrupts toll-like receptor 2 signaling pathway in Pam3CSK4-stimulated macrophages, Toxicology and Environmental Health Sciences, 7, 3, 2015. Crossref
-
Mizutani Akiei, Shaheen Victoria M., Yoshida Hideo, Akaogi Jun, Kuroda Yoshiki, Nacionales Dina C., Yamasaki Yoshioki, Hirakata Michito, Ono Nobutaka, Reeves Westley H., Satoh Minoru, Pristane-induced autoimmunity in germ-free mice, Clinical Immunology, 114, 2, 2005. Crossref
-
Rastogi D., Ratner A.J., Prince A., Host–bacterial interactions in the initiation of inflammation, Paediatric Respiratory Reviews, 2, 3, 2001. Crossref
-
Makihira Seicho, Mine Yuichi, Nikawa Hiroki, Shuto Takahiro, Iwata Satoshi, Hosokawa Ryuji, Kamoi Kohei, Okazaki Shota, Yamaguchi Yu, Titanium ion induces necrosis and sensitivity to lipopolysaccharide in gingival epithelial-like cells, Toxicology in Vitro, 24, 7, 2010. Crossref
-
Ozaki Yukio, Ukai Takashi, Yamaguchi Masayuki, Yokoyama Miho, Ayón Haro Esperanza R., Yoshimoto Mayumi, Kaneko Takashi, Yoshinaga Miho, Nakamura Hirotaka, Shiraishi Chiaki, Hara Yoshitaka, Locally administered T cells from mice immunized with lipopolysaccharide (LPS) accelerate LPS-induced bone resorption, Bone, 44, 6, 2009. Crossref
-
Strindelius Lena, Filler Malin, Sjöholm Ingvar, Mucosal immunization with purified flagellin from Salmonella induces systemic and mucosal immune responses in C3H/HeJ mice, Vaccine, 22, 27-28, 2004. Crossref
-
Szabo Gyongyi, Dolganiuc Angela, Hepatitis C and Innate Immunity: Recent Advances, Clinics in Liver Disease, 12, 3, 2008. Crossref
-
Jiang Hong-Wei, Zhang Wei, Ren Bang-Peng, Zeng Jin-Feng, Ling Jun-Qi, Expression of Toll Like Receptor 4 in Normal Human Odontoblasts and Dental Pulp Tissue, Journal of Endodontics, 32, 8, 2006. Crossref
-
Ernst Robert K., Guina Tina, Miller Samuel I., Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity, Microbes and Infection, 3, 14-15, 2001. Crossref
-
Zhang Ping, Katz Jenny, Michalek Suzanne M., Glycogen synthase kinase-3β (GSK3β) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice, Molecular Immunology, 46, 4, 2009. Crossref
-
Gumperz Jenny E, Brenner Michael B, CD1-specific T cells in microbial immunity, Current Opinion in Immunology, 13, 4, 2001. Crossref
-
Rasley Amy, Anguita Juan, Marriott Ian, Borrelia burgdorferi induces inflammatory mediator production by murine microglia, Journal of Neuroimmunology, 130, 1-2, 2002. Crossref
-
Lee Mi Jin, Park Mi-Young, Kim Soon-Kyung, Aloe-emodin inhibits Pam3CSK4-induced MAPK and NF-κB signaling through TLR2 in macrophages, Journal of Nutrition and Health, 49, 4, 2016. Crossref
-
Slotta J. E., Braun O. Ö., Menger M. D., Thorlacius H., Capture of platelets to the endothelium of the femoral vein is mediated by CD62P and CD162, Platelets, 20, 7, 2009. Crossref
-
Qian Jing, Ren Chunhua, Xia Jianjun, Chen Ting, Yu Zonghe, Hu Chaoqun, Discovery, structural characterization and functional analysis of alpha-2-macroglobulin, a novel immune-related molecule from Holothuria atra, Gene, 585, 2, 2016. Crossref
-
Seo Dong-Won, Cho Yong-Il, Gu Suna, Kim Da-Hee, Park Jung-Hee, Yi Young-Joo, Lee Sang-Myeong, A hot water extract ofAralia cordataactivates bone marrow-derived macrophages via a myeloid differentiation protein 88-dependent pathway and protects mice from bacterial infection, Microbiology and Immunology, 60, 5, 2016. Crossref
-
Funakoshi-Tago Megumi, Ohsawa Kentaro, Ishikawa Toshiyuki, Nakamura Fumika, Ueda Fumihito, Narukawa Yuji, Kiuchi Fumiyuki, Tamura Hiroomi, Tago Kenji, Kasahara Tadashi, Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway, International Immunopharmacology, 40, 2016. Crossref
-
Enkhbaatar Perenlei, Nelson Christina, Salsbury John R., Carmical Joseph R., Torres Karen E. O., Herndon David, Prough Donald S., Luan Liming, Sherwood Edward R., Tuckermann Jan Peter, Comparison of Gene Expression by Sheep and Human Blood Stimulated with the TLR4 Agonists Lipopolysaccharide and Monophosphoryl Lipid A, PLOS ONE, 10, 12, 2015. Crossref
-
Hung Wei-Shan, Ling Pin, Cheng Ju-Chien, Chang Shy-Shin, Tseng Ching-Ping, Disabled-2 is a negative immune regulator of lipopolysaccharide-stimulated Toll-like receptor 4 internalization and signaling, Scientific Reports, 6, 1, 2016. Crossref
-
Wilson Malinda, Widdicombe Jonathan H., Gohil Kishorchandra, Burtis Kenneth C., Reznick Abraham Z., Cross Carroll E., Eiserich Jason P., AreDrosophilaa Useful Model for Understanding the Toxicity of Inhaled Oxidative Pollutants: A Review, Inhalation Toxicology, 17, 13, 2005. Crossref
-
Qian Jing, Ren Chunhua, Chen Ting, Xia Jianjun, Yu Zonghe, Gao Yan, Hu Chaoqun, Identification and functional characterization of first alpha‐2‐macroglobulin in sea cucumbers, Aquaculture Research, 48, 5, 2017. Crossref
-
Malgorzata-Miller Gosia, Heinbockel Lena, Brandenburg Klaus, van der Meer Jos W. M., Netea Mihai G., Joosten Leo A. B., Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications, Scientific Reports, 6, 1, 2016. Crossref
-
Frost Robert A., Nystrom Gerald J., Lang Charles H., Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 283, 3, 2002. Crossref
-
Frleta Davor, Noelle Randolph J., Wade William F., CD40-mediated up-regulation of Toll-like receptor 4-MD2 complex on the surface of murine dendritic cells, Journal of Leukocyte Biology, 74, 6, 2003. Crossref
-
Vieira Frederico, Kung Johannes W., Bhatti Faizah, Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins, Annals of Anatomy - Anatomischer Anzeiger, 211, 2017. Crossref
-
Murata Yukie, Yamashita Akira, Saito Takashi, Sugamura Kazuo, Hamuro Junji, The conversion of redox status of peritoneal macrophages during pathological progression of spontaneous inflammatory bowel disease in Janus family tyrosine kinase 3–/– and IL‐2 receptor γ–/– mice, International Immunology, 14, 6, 2002. Crossref
-
Kaushik Deepak Kumar, Gupta Malvika, Kumawat Kanhaiya Lal, Basu Anirban, Wang Tian, NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis, PLoS ONE, 7, 2, 2012. Crossref
-
Billack Blase, Heck Diane E., Mariano Thomas M., Gardner Carol R., Sur Runa, Laskin Debra L., Laskin Jeffrey D., Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells, American Journal of Physiology-Cell Physiology, 283, 4, 2002. Crossref
-
Kim Yun Jeong, Kim Jeong-Hee, Lee Kwang-Jun, Choi Myung-Min, Kim Yeon Hee, Rhie Gi-eun, Yoo Cheon-Kwon, Cha Kiweon, Shin Na-Ri, Johnson Eric A., Botulinum Neurotoxin Type A Induces TLR2-Mediated Inflammatory Responses in Macrophages, PLOS ONE, 10, 4, 2015. Crossref
-
Murata Yukie, Shimamura Toshiro, Hamuro Junji, The polarization of Th1/Th2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production, International Immunology, 14, 2, 2002. Crossref
-
Xiao Xingxing, Zhang Yun, Wei Qiaolin, Yin Xiangping, Flagellin FljB as an adjuvant to the recombinant adenovirus rabies glycoprotein vaccine increases immune responses against rabies in mice, Archives of Virology, 162, 9, 2017. Crossref
-
Anderson Charles F., Gerber Jeffrey S., Mosser David M., Modulating macrophage function with IgG immune complexes, Journal of Endotoxin Research, 8, 6, 2002. Crossref
-
Kim Sung Ouk, Ono Koh, Han Jiahuai, Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages, American Journal of Physiology-Lung Cellular and Molecular Physiology, 281, 5, 2001. Crossref
-
Liu Q., Hamblin M. R., Macrophage-Targeted Photodynamic Therapy: Scavenger Receptor Expression and Activation State, International Journal of Immunopathology and Pharmacology, 18, 3, 2005. Crossref
-
Moretto Magali M., Khan Imtiaz A., Weiss Louis M., Knoll Laura J., Gastrointestinal Cell Mediated Immunity and the Microsporidia, PLoS Pathogens, 8, 7, 2012. Crossref
-
Yamamoto Kana, Furuya Kanon, Yamada Kazuki, Takahashi Fuka, Hamajima Chisato, Tanaka Sachi, Enhancement of natural killer activity and IFN-γ production in an IL-12-dependent manner by a Brassica rapa L., Bioscience, Biotechnology, and Biochemistry, 82, 4, 2018. Crossref
-
Kim Min-Sung, Byun Minji, Oh Byung-Ha, Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster, Nature Immunology, 4, 8, 2003. Crossref
-
Tarabees R., Hill D., Rauch C., Barrow P. A., Loughna P. T., Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubes, American Journal of Physiology-Cell Physiology, 301, 4, 2011. Crossref
-
Feingold Kenneth R., Shigenaga Judy K., Kazemi Mahmood R., McDonald Carol M., Patzek Sophie M., Cross Andrew S., Moser Arthur, Grunfeld Carl, Mechanisms of triglyceride accumulation in activated macrophages, Journal of Leukocyte Biology, 92, 4, 2012. Crossref
-
Ryu Yun-Kyoung, Lee Mi-Hee, Lee Jiyoung, Lee Jae-Wook, Jang Su-Jin, Kang Joo-Hyun, Moon Eun-Yi, γ-Irradiated cancer cells promote tumor growth by activation of Toll-like receptor 1-mediated inducible nitric oxide synthase in macrophages, Journal of Leukocyte Biology, 97, 4, 2015. Crossref
-
Nathan Carl, Ding Aihao, TREM-1: A new regulator of innate immunity in sepsis syndrome, Nature Medicine, 7, 5, 2001. Crossref
-
Pereira João Pedro, Girard Robert, Chaby Richard, Cumano Ana, Vieira Paulo, Monoallelic expression of the murine gene encoding Toll-like receptor 4, Nature Immunology, 4, 5, 2003. Crossref
-
Ferraris Davide, Miggiano Riccardo, Rossi Franca, Rizzi Menico, Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets, Pathogens, 7, 1, 2018. Crossref
-
Cai Xiaoyu, Zhang Lingling, Wei Wei, Regulatory B cells in inflammatory diseases and tumor, International Immunopharmacology, 67, 2019. Crossref
-
Berger T. G., Schultz E. S., Dendritic Cell-Based Immunotherapy, in Dendritic Cells and Virus Infection, 276, 2003. Crossref
-
Ferreira Isabel, Silva Ana, Martins João Demétrio, Neves Bruno Miguel, Cruz Maria Teresa, Nature and kinetics of redox imbalance triggered by respiratory and skin chemical sensitizers on the human monocytic cell line THP-1, Redox Biology, 16, 2018. Crossref
-
Rogler Gerhard, Multi-site therapeutic modalities for inflammatory bowel diseases — mechanisms of action, in Inflammatory Bowel Disease: From Bench to Bedside, 2003. Crossref
-
Hoth J. Jason, Wells Jonathan D., Brownlee Noel A., Hiltbold Elizabeth M., Meredith J. Wayne, McCall Charles E., Yoza Barbara K., TOLL-LIKE RECEPTOR 4-DEPENDENT RESPONSES TO LUNG INJURY IN A MURINE MODEL OF PULMONARY CONTUSION, Shock, 31, 4, 2009. Crossref
-
Wang Tiancheng, Guo Mengyao, Song Xiaojing, Zhang Zecai, Jiang Haichao, Wang Wei, Fu Yunhe, Cao Yongguo, Zhu Lianqin, Zhang Naisheng, Stevioside Plays an Anti-inflammatory Role by Regulating the NF-κB and MAPK Pathways in S. aureus-infected Mouse Mammary Glands, Inflammation, 37, 5, 2014. Crossref
-
Hua Kuo-Feng, Chen Guan-Ming, Ho Chen-Lung, Chen Ming-Chung, Chen Yi-Lin Sophia, Chen Wei-Jung, Huang Jeng-Fang, Perng Yuan-Shing, Lin Chai-Ching, Freshwater Clam Extract Inhibits Inflammatory Responses in LPS-Activated Macrophages by Reducing the Activation of Mitogen-Activated Protein Kinases and NF-κB, Natural Product Communications, 7, 11, 2012. Crossref
-
Oh Gi-Su, Kim Hyung-Jin, Choi Jae-Hyuck, Shen AiHua, Kim Chang-Hoi, Kim Se-Jin, Shin Sae-Ron, Hong Seung-Heon, Kim Yunha, Park Channy, Lee Sung-Joong, Akira Shizuo, Park Raekil, So Hong-Seob, Activation of Lipopolysaccharide–TLR4 Signaling Accelerates the Ototoxic Potential of Cisplatin in Mice, The Journal of Immunology, 186, 2, 2011. Crossref
-
S. Ehlers, Hölscher C., Immunologie der Infektabwehr, in Die Infektiologie, 2004. Crossref
-
Müller Werner, Immunologie und die Entsorgung großer Abfallprodukte, in Tier- und Humanphysiologie, 2004. Crossref
-
Curry Jonathan L., Reuben Alexandre, Szczepaniak‐Sloane Robert, Ning Jing, Milton Denái R., Lee Chi H., Hudgens Courtney, George Saira, Torres‐Cabala Carlos, Johnson Daniel, Subramanya Sandesh, Wargo Jennifer A., Mudaliar Kumaran, Wistuba Ignacio I., Prieto Victor G., Diab Adi, Tetzlaff Michael T., Gene expression profiling of lichenoid dermatitis immune‐related adverse event from immune checkpoint inhibitors reveals increased CD14+and CD16+monocytes driving an innate immune response, Journal of Cutaneous Pathology, 46, 9, 2019. Crossref
-
Schilling Joel D., Machkovech Heather M., He Li, Diwan Abhinav, Schaffer Jean E., TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death through a TRIF-Dependent Pathway, The Journal of Immunology, 190, 3, 2013. Crossref
-
Kis-Toth Katalin, Szanto Attila, Thai To-Ha, Tsokos George C., Cytosolic DNA-Activated Human Dendritic Cells Are Potent Activators of the Adaptive Immune Response, The Journal of Immunology, 187, 3, 2011. Crossref
-
Rogler Gerhard, Multi-site therapeutic modalities for inflammatory bowel diseases — mechanisms of action, in Inflammatory Bowel Disease: From Bench to Bedside, 2005. Crossref
-
SOMECH RAZ, AMARIGLIO NINETTE, SPIRER ZVI, RECHAVI GIDEON, Genetic predisposition to infectious pathogens: a review of less familiar variants, Pediatric Infectious Disease Journal, 22, 5, 2003. Crossref
-
Dai Yalei, Datta Shyamsree, Novotny Michael, Hamilton Thomas A., TGFβ inhibits LPS-induced chemokine mRNA stabilization, Blood, 102, 4, 2003. Crossref
-
Bland David A., Barrera Carlos A., Reyes Victor E., Gastrointestinal Mucosal Immunology, in Mucosal Immunology and Virology, 2006. Crossref
-
Maitra Urmila, Gan Lu, Chang Samantha, Li Liwu, Low-Dose Endotoxin Induces Inflammation by Selectively Removing Nuclear Receptors and Activating CCAAT/Enhancer-Binding Protein δ, The Journal of Immunology, 186, 7, 2011. Crossref
-
Fukushima Ryuichiro, Soejima Hirofumi, Fukunaga Takashi, Nakayama Masafumi, Oe Yoko, Oshima Shuichi, Sugiyama Seigo, Ogawa Hisao, Expression Levels of Toll-Like Receptor Genes in Coronary Atherosclerotic Lesions of Patients With Acute Coronary Syndrome or Stable Angina Pectoris, Circulation Journal, 73, 8, 2009. Crossref
-
Yoshikai Yasunobu, Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection, Current Opinion in Infectious Diseases, 14, 3, 2001. Crossref
-
Steckelings U. Muscha, Sumners Colin, Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT2-receptor agonists, Clinical Science, 134, 22, 2020. Crossref
-
Zhang Wei, An Eun-Koung, Hwang Juyoung, Jin Jun-O, Mice Plasmacytoid Dendritic Cells Were Activated by Lipopolysaccharides Through Toll-Like Receptor 4/Myeloid Differentiation Factor 2, Frontiers in Immunology, 12, 2021. Crossref
-
Ishiguro Kazuhiro, Kadomatsu Kenji, Kojima Tetsuhito, Muramatsu Hisako, Iwase Mitsunori, Yoshikai Yasunobu, Yanada Masamitsu, Yamamoto Koji, Matsushita Tadashi, Nishimura Masahiko, Kusugami Kazuo, Saito Hidehiko, Muramatsu Takashi, Syndecan-4 Deficiency Leads to High Mortality of Lipopolysaccharide-injected Mice, Journal of Biological Chemistry, 276, 50, 2001. Crossref
-
Ikwegbue Paul Chukwudi, Revaprasadu Neerish, Kappo Abidemi Paul, Therapeutic Potential of Heat Shock Proteins in Human Inflammation/Autoimmune Skin Diseases: Future Directions, in Heat Shock Proteins in Inflammatory Diseases, 22, 2020. Crossref
-
Kirk Sean G., Murphy Parker R., Wang Xiantao, Cash Charles J., Barley Timothy J., Bowman Bridget A., Batty Abel J., Ackerman William E., Zhang Jian, Nelin Leif D., Hafner Markus, Liu Yusen, Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection, The Journal of Immunology, 206, 12, 2021. Crossref
-
Phulphagar Kshiti, Kühn Lars I., Ebner Stefan, Frauenstein Annika, Swietlik Jonathan J., Rieckmann Jan, Meissner Felix, Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis, Cell Reports, 34, 10, 2021. Crossref
-
Curry Jonathan L., Qin Jian-Zhong, Bonish Brian, Carrick Ryan, Bacon Patricia, Panella Jeffrey, Robinson June, Nickoloff Brian J., Innate Immune-Related Receptors in Normal and Psoriatic Skin, Archives of Pathology & Laboratory Medicine, 127, 2, 2003. Crossref
-
Sing Andreas, Tvardovskaia Natalia, Rost Dagmar, Kirschning Carsten J., Wagner Hermann, Heesemann Jürgen, Contribution of Toll-like receptors 2 and 4 in an oral Yersinia enterocolitica mouse infection model, International Journal of Medical Microbiology, 293, 5, 2003. Crossref
-
Sheu Fuu, Chien Po-Jung, Hsieh Kuang-Yang, Chin Kah-Lock, Huang Wan-Ting, Tsao Chiao-Yin, Chen Yin-Fang, Cheng Hui-Chung, Chang Hui-Hsin, Purification, Cloning, and Functional Characterization of a Novel Immunomodulatory Protein from Antrodia camphorata (Bitter Mushroom) That Exhibits TLR2-Dependent NF-κB Activation and M1 Polarization within Murine Macrophages, Journal of Agricultural and Food Chemistry, 57, 10, 2009. Crossref
-
Su Kang-Yi, Yu Chao Yuan, Chen Ya-Ping, Hua Kuo-Feng, Chen Yi-Lin Sophia, 3,4-Dihydroxytoluene, a metabolite of rutin, inhibits inflammatory responses in lipopolysaccharide-activated macrophages by reducing the activation of NF-κB signaling, BMC Complementary and Alternative Medicine, 14, 1, 2014. Crossref
-
Berman Reena, Rose Cecile S., Downey Gregory P., Day Brian J., Chu Hong Wei, Role of Particulate Matter from Afghanistan and Iraq in Deployment-Related Lung Disease, Chemical Research in Toxicology, 34, 12, 2021. Crossref
-
Olona Antoni, Hateley Charlotte, Muralidharan Sneha, Wenk Markus R., Torta Federico, Behmoaras Jacques, Sphingolipid metabolism during Toll‐like receptor 4 (TLR4)‐mediated macrophage activation, British Journal of Pharmacology, 178, 23, 2021. Crossref
-
Pieters Jean, Manipulation of the Macrophage Response by Pathogenic Mycobacteria, in Handbook of Tuberculosis, 2008. Crossref
-
Yamada Kelsey J., Barker Tolga, Dyer Kimberly D., Rice Tyler A., Percopo Caroline M., Garcia-Crespo Katia E., Cho Soochin, Lee James J., Druey Kirk M., Rosenberg Helene F., Eosinophil-associated Ribonuclease 11 Is a Macrophage Chemoattractant, Journal of Biological Chemistry, 290, 14, 2015. Crossref
-
Hise A G, Hazlett F E, Bockarie M J, Zimmerman P A, Tisch D J, Kazura J W, Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis, Genes & Immunity, 4, 7, 2003. Crossref
-
Schilling Joel D., Machkovech Heather M., He Li, Sidhu Rohini, Fujiwara Hideji, Weber Kassandra, Ory Daniel S., Schaffer Jean E., Palmitate and Lipopolysaccharide Trigger Synergistic Ceramide Production in Primary Macrophages, Journal of Biological Chemistry, 288, 5, 2013. Crossref
-
Bhatt Kamlesh, Salgame Padmini, Host Innate Immune Response to Mycobacterium tuberculosis , Journal of Clinical Immunology, 27, 4, 2007. Crossref
-
Cao Shanjin, Zhang Xia, Edwards Justin P., Mosser David M., NF-κB1 (p50) Homodimers Differentially Regulate Pro- and Anti-inflammatory Cytokines in Macrophages, Journal of Biological Chemistry, 281, 36, 2006. Crossref
-
Mohty M, Gaugler B, Dendritic cells: interfaces with immunobiology and medicine. A report from the Keystone Symposia Meeting held in Keystone, 3–8 March 2003, Leukemia, 17, 9, 2003. Crossref
-
Schilling Joel D., Martin Steven M., Hung Chia S., Lorenz Robin G., Hultgren Scott J., Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli , Proceedings of the National Academy of Sciences, 100, 7, 2003. Crossref
-
Tsolaki Anthony G., Varghese Praveen Mathews, Kishore Uday, Innate Immune Pattern Recognition Receptors of Mycobacterium tuberculosis: Nature and Consequences for Pathogenesis of Tuberculosis, in Microbial Pathogenesis, 1313, 2021. Crossref
-
Sugawara Shunji, Interleukin-18 and oral mucosal immunity, International Congress Series, 1284, 2005. Crossref
-
Aloisi Francesca, Immune function of microglia, Glia, 36, 2, 2001. Crossref
-
Almeida Igor C., Gazzinelli Ricardo T., Proinflammatory activity of glycosylphosphatidylinositol anchors derived from Trypanosoma cruzi : structural and functional analyses , Journal of Leukocyte Biology, 70, 4, 2001. Crossref
-
Berner Jakob, Weiss Tamara, Sorger Helena, Rifatbegovic Fikret, Kauer Max, Windhager Reinhard, Dohnal Alexander, Ambros Peter F., Ambros Inge M., Boztug Kaan, Steinberger Peter, Taschner‐Mandl Sabine, Human repair‐related Schwann cells adopt functions of antigen‐presenting cells in vitro, Glia, 70, 12, 2022. Crossref
-
GHODE GAJANAN, RATHORE GAURAV, TRIPATHI GAYATRI, DAVANE KASHMIRA, PRASAD KURUCHETI PANI, Molecular cloning, characterization and constitutive expression analysis of TLR4 gene in Pangasianodon hypophthalmus, The Indian Journal of Animal Sciences, 92, 10, 2022. Crossref
-
Paterson Hugh M., Murphy Thomas J., Purcell Elizabeth J., Shelley Odhran, Kriynovich Sara J., Lien Egil, Mannick John A., Lederer James A., Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity, The Journal of Immunology, 171, 3, 2003. Crossref
-
Jang Sihyug, Uematsu Satoshi, Akira Shizuo, Salgame Padmini, IL-6 and IL-10 Induction from Dendritic Cells in Response to Mycobacterium tuberculosis Is Predominantly Dependent on TLR2-Mediated Recognition, The Journal of Immunology, 173, 5, 2004. Crossref