Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.404 Factor de Impacto de 5 años: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v29.i3.20
pages 203-217

Exosome Release by Primary B Cells

Alexander McLellan
Department of Microbiology and Immunology, University of Otago, Dunedin, NZ 9054


Exosomes are subcellular nanoparticles derived from the endosomal pathway. It is now becoming clear that a potential major in vivo source of exosomes is the B cell. Although it has been widely assumed that exosome release is a constitutive activity of most cell types, recent work has emphasized the role of cellular activation in the release of exosomes from primary cells. Like other lymphocytes, B cells undergo extensive cellular physiologic changes during the process of differentiation into effector cells. One newly identified feature of this process is exosome synthesis, which is initiated following the receipt of activation signals, particularly T-cell "help" via CD40 and IL-4 signaling. B-cell-derived exosomes contain immunoglobulin, which traffics antigen bound by the surface B-cell receptor (BCR) into the endosomal/exosomal pathway and finally into the extracellular space. Exosomes have been implicated in viral transmission, cell signaling, and antigen presentation, as well as in the disposal of effete or defective cellular components. However, the possible targets of B-cell-derived exosomes remain unknown. This review focuses on the synthesis and release of exosomes derived from activated and malignant B cells and explores the possible functions of B-cell-derived exosomes in immune function.

PALABRAS CLAVE: B cells, CD40, IL-4, exosomes

Articles with similar content:

Functions of CD40 and Its Ligand, gp39 (CD40L)
Critical Reviews™ in Immunology, Vol.16, 1996, issue 1
Jon D. Laman, Randolph J. Noelle, Eric Claassen
Opposing Forces in Asthma: Regulation of Signaling Pathways by Kinases and Phosphatases
Critical Reviews™ in Immunology, Vol.29, 2009, issue 5
Philippe Pouliot, Martin Olivier
Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases
Critical Reviews™ in Immunology, Vol.36, 2016, issue 2
Nicole Baumgarth, Trang T. T. Nguyen
Role of SLAM Family Receptors and Specific Adapter SAP in Innate-Like Lymphocytes
Critical Reviews™ in Immunology, Vol.34, 2014, issue 4
Jordi Sintes, Xavier Romero, Pablo Engel
The Inflammasome and Its Regulation
Critical Reviews™ in Immunology, Vol.34, 2014, issue 1
Hideki Hara, Kohsuke Tsuchiya