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Critical Reviews™ in Immunology
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ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i1.40
pages 61-94

The Role of Plasmacytoid Dendritic Cell-Derived IFNα in Antiviral Immunity

Gyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, Worcester, MA
Angela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, MA

SINOPSIS

Viral infections represent a major source of acute and chronic human disease. The immune system plays a central role in the elimination of viruses through its ability to recognize pathogens and to induce virus-specific cellular activation, accompanied by a robust production of soluble molecules with antiviral effects. Interferons are among the most powerful natural soluble antiviral molecules. Upon viral infection, interferons are produced by a variety of cell types, with immune cells being the main contributors. The immune system works as a well-orchestrated team composed of multiple cell types. The mechanisms of intercellular cooperation that includes dendritic cells (DCs), their soluble factors, and different types of immune cells are yet to be fully understood. Further, the effects of viral infections on interimmune cooperation need to be investigated. In this review, we define the role of plasmacytoid dendritic cells (PDC) and PDC-derived interferon alpha (IFNα) during viral infections. Specifically, we address the mechanisms of IFNα induction and the cooperation between PDC, PDC-derived IFNα and T cells, B cells, NK, iNKT, and myeloid dendric cells in antiviral immune responses.


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