Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.352 Factor de Impacto de 5 años: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumes:
Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v18.i6.20
pages 503-524

The Structure and Function of γс-Dependent Cytokines and Receptors: Regulation of T Lymphocyte Development and Homeostasis

You-Wen He
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33136.
Thomas R. Malek
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33136.

SINOPSIS

Five cytokines, IL-2, IL-4, IL-7, IL-9, and IL-15, form one group that is characterized by utilizing the common γ chain (γc) as a receptor subunit. Examination of the phenotype of various cytokine or cytokine receptor "knockout" mice demonstrates that these cytokines are critical for normal lymphocyte development and subsequent functional activity of the peripheral immune compartment. This review summarizes the structural and functional properties of each of these five cytokines and their receptors, including the known redundant pathways for each cytokine or receptor. The contribution of these cytokines and receptors will then be considered in detail with respect to regulation of T lymphocyte development and homeostasis of the peripheral T cell compartment.


Articles with similar content:

Role of Inflammation Amplifier-Induced Growth Factor Expression in the Development of Inflammatory Diseases
Critical Reviews™ in Immunology, Vol.35, 2015, issue 5
Yasunobu Arima, Daisuke Kamimura, Masaaki Murakami, Toru Atsumi, Ikuma Nakagawa
Cellular Components and Mechanisms of Oral Tolerance Induction
Critical Reviews™ in Immunology, Vol.38, 2018, issue 3
Rafael M. Rezende, Howard L. Weiner
Transcriptional Regulation of IL-10 and Its Cell-Specific Role In Vivo
Critical Reviews™ in Immunology, Vol.34, 2014, issue 4
J. Simon C. Arthur, Kirsty F. MacKenzie, Michael J. Pattison
Macrophage Polarization: Implications on Metabolic Diseases and the Role of Exercise
Critical Reviews™ in Eukaryotic Gene Expression, Vol.26, 2016, issue 2
Loreana Sanches Silveira, Barbara de Moura Mello Antunes, José Cesar Rosa Neto, Ronaldo Vagner Thomatieli dos Santos, Fábio Santos Lira, Andre Luis Araujo Minari
Regulatory Mechanisms Operative in Osteoclasts
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 4
Sakamuri V. Reddy