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Critical Reviews™ in Immunology
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ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v32.i2.30
pages 139-155

Crosstalk between T Lymphocytes and Dendritic Cells

Claire Hivroz
Institut Curie, Centre de Recherche, Pavilion Pasteur, 26 Rue d'ULM, Paris, F-75248 ; INSERM, Unité 932, Immunité et Cancer, Paris, F-75248, France
Karine Chemin
Institut Curie, Centre de Recherche, Pavilion Pasteur, 26 Rue d'ULM, Paris, F-75248 ; INSERM, Unité 932, Immunité et Cancer, Paris, F-75248, France ; Center for Molecular Medicine (CMM), Rheumatology Unit, Department of Medicine, Karolinska Inst
Marie Tourret
Institut Curie, Centre de Recherche, Pavilion Pasteur, 26 Rue d'ULM, Paris, F-75248 ; INSERM, Unité 932, Immunité et Cancer, Paris, F-75248, France
Armelle Bohineust
Institut Curie, Centre de Recherche, Pavilion Pasteur, 26 Rue d'ULM, Paris, F-75248 ; INSERM, Unité 932, Immunité et Cancer, Paris, F-75248, France

SINOPSIS

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique property of inducing priming and differentiation of naïve CD4+ and CD8+ T cells into helper and cytotoxic effectors. Their efficiency is due to their unique ability to process antigen, express costimulatory molecules, secrete cytokines, and migrate to tissues or lymphoid organs to prime T cells. DCs also play an important role in T-cell peripheral tolerance. There is ample evidence that the DC ability to present antigens is regulated by CD4+ helper T cells. Indeed, interactions between surface receptors and ligands expressed respectively by T cells and DCs, as well as T-cell-derived cytokines modify DC functions. This T-cell-induced modification of DCs has been called "education" or "licensing." This intimate crosstalk between DCs and T lymphocytes is key in establishing appropriate adaptive immune responses. It requires cognate interactions between T lymphocytes and DCs, which are organized in time and space by structures called immunological synapses. Here we discuss the particular aspects of immunological synapses formed between T cells and DCs and the role these organized interactions have in T-cell-DC crosstalk.


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