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Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Mechanisms of Cholera Toxin in the Modulation of TH17 Responses

Volumen 35, Edición 2, 2015, pp. 135-152
DOI: 10.1615/CritRevImmunol.2015012295
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SINOPSIS

Numerous studies have shown that TH17 cells and their signature cytokine IL-17A are critical to host defense against various bacterial and fungal infections. The protective responses mediated by TH17 cells and IL-17A include the recruitment of neutrophils, release of antimicrobial peptides and chemokines, and enhanced tight junction of epithelial cells. Due to the importance of TH17 cells in infections, efforts have been made to develop TH17-based vaccines. The goal of vaccination is to establish a protective immunological memory. Most currently approved vaccines are antibody-based and have limited protection against stereotypically different strains. Studies show that T-cell-based vaccines may overcome this limitation and protect hosts against infection of different strains.
Two main strategies are used to develop TH17 vaccines: identification of TH17-specific antigens and TH17-skewing adjuvants. Studies have revealed that cholera toxin (CT) induces a potent Th17 response following vaccination. Antigen vaccination along with CT induces a robust TH17 response, which is sometimes accompanied by TH1 responses. Due to the toxicity of CT, it is hard to apply CT in a clinical setting. Thus, understanding how CT modulates TH17 responses may lead to the development of successful TH17-based vaccines.

CITADO POR
  1. Lee Eun-Young, Kim Joo-Young, Lee Deuk-Ki, Yoon Il-Sub, Ko Hae Li, Chung Ji-Woo, Chang Jun, Nam Jae-Hwan, Sublingual immunization with Japanese encephalitis virus vaccine effectively induces immunity through both cellular and humoral immune responses in mice, Microbiology and Immunology, 60, 12, 2016. Crossref

  2. Zhang Ying, Han Ji-cheng, Jing Jie, Liu Hao, Zhang He, Li Zhao-hui, Jin Ning-yi, Lu Hui-jun, Construction and Immunogenicity of Recombinant Vaccinia Virus Vaccine Against Japanese Encephalitis and Chikungunya Viruses Infection in Mice, Vector-Borne and Zoonotic Diseases, 20, 10, 2020. Crossref

  3. O’Connor Emma B., Muñoz-Wolf Natalia, Leon Gemma, Lavelle Ed C., Mills Kingston H. G., Walsh Patrick T., Porter Richard K., O’Reilly Steven, UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation, PLOS ONE, 15, 11, 2020. Crossref

  4. He Qian, Jiang Lang, Cao Kangli, Zhang Linxia, Xie Xinci, Zhang Shuye, Ding Xiangqing, He Yongquan, Zhang Miaomiao, Qiu Tianyi, Jin Xuanxuan, Zhao Chen, Zhang Xiaoyan, Xu Jianqing, A Systemic Prime–Intrarectal Pull Strategy Raises Rectum-Resident CD8+ T Cells for Effective Protection in a Murine Model of LM-OVA Infection, Frontiers in Immunology, 11, 2020. Crossref

  5. Cassady-Cain Robin L., Hope Jayne C., Stevens Mark P., Andrews-Polymenis Helene L., Direct Manipulation of T Lymphocytes by Proteins of Gastrointestinal Bacterial Pathogens, Infection and Immunity, 86, 5, 2018. Crossref

  6. Prawiro Sumarno Reto, Poeranto Sri, Amalia Aisyah, Widyani Elsa Larissa, Indraswari Genitri, Soraya Merika, Dwi Pradipto Septha Rully, Prasetya Adrian, Hidayat Guntur Rizal, Alitha Putri Safira Nur, Generating Mucosal and Systemic Immune Response Following Vaccination of Vibrio cholerae Adhesion Molecule against Shigella flexneri Infection, Indian Journal of Medical Microbiology, 38, 1, 2020. Crossref

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