Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.352 Factor de Impacto de 5 años: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumes:
Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v16.i3.10
pages 223-250

Genes Responsible for Quantitative Regulation of Antibody Production

Anne Puel
Laboratoire d'lmmunogenetique, Unite INSERM 255, Institut Curie, 26, rue d'Ulm, 75231 PARIS CEDEX 05, FRANCE
Denise Mouton
Laboratoire d'lmmunogenetique, Unite INSERM 255, Institut Curie, 26, rue d'Ulm, 75231 PARIS CEDEX 05, FRANCE

SINOPSIS

Evidence is first presented demonstrating that the individual capacity for antibody responsiveness has an inheritable component. The main evidence consists of spontaneous mutations causing either immunodeficiency or predisposition to autoimmunity in human and animals, and the involvement of some obvious candidate genes (in particular those belonging to the highly polymorphic histocompatibility and Igh loci), extensively analyzed in many mouse strain combinations. One finding constantly emerging from these studies is that single gene expression depends on environmental effects, lowering the genotype/phenotype correlation, but also on multigenic interactions appearing as background effects. The models available for the analysis of this multigenic regulation are discussed with special emphasis on the high and low antibody responder mice produced for this purpose by bidirectional selective breeding. The major advantage of this model is that the interline difference is huge and multispecifically expressed. The second part of the review presents the recent results on positional mapping of genes with immunomodulatory effects in this model and in one appropriate recombinant congenic strain series. This in vivo genetic dissection of antibody responsiveness discriminated the involvement of candidate genes and suggested that unsuspected genes might be identified by means of this wide open search.


Articles with similar content:

DNA Target Motifs of Somatic Mutagenesis in Antibody Genes
Critical Reviews™ in Immunology, Vol.22, 2002, issue 3
Gary S. Shapiro, Lawrence J. Wysocki
Biological and Clinical Significance of Human NKRP1A/LLT1 Receptor/Ligand Interactions
Critical Reviews™ in Immunology, Vol.38, 2018, issue 6
Jacek Malejczyk, Agata Bialoszewska
The Role of Immunoproteins in the Survival
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.14, 1997, issue 2
Dana V. Devine, Jihan M. J. Marjan
Immune Function of the Decoy Receptor Osteoprotegerin
Critical Reviews™ in Immunology, Vol.22, 2002, issue 3
Elizabeth J. Ryan, Asa K. Bengtsson
Expression and Function of Recombination Activating Genes in Mature В Cells
Critical Reviews™ in Immunology, Vol.18, 1998, issue 3
Masaki Hikida, Hitoshi Ohmori