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Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Structural Plasticity of the Proteasome and Its Function in Antigen Processing

Volumen 21, Edición 4, 2001, 21 pages
DOI: 10.1615/CritRevImmunol.v21.i4.30
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SINOPSIS

The proteasome is the main provider of peptide ligands for major histocompatibility complex class I molecules. During an immune response to pathogens, the proinflammatory cytokine interferon (IFN)-g and tumor necrosis factor (TNF)-a are released, which induce the proteasome subunits LMP2, LMP7, and MECL-1. These replace the constitutively expressed active site subunits of the proteasome (delta, MB1, and Z) leading to a marked change in the cleavage preference of the proteasome and the production of T-cell epitopes. Proteasome activity is further changed by the IFN)-g–mediated induction of the proteasome regulator PA28a/b and the downregulation of PA28g. Why such an extensive exchange of proteasome active site subunits and regulators occurs is still poorly understood. In this article we discuss recent insights in the structural consequences of proteasome reorganization and their effects on epitope generation and shaping of the cytotoxic immune response. Moreover, we review the latest data on how the ubiquitin pathway targets protein antigens for peptide processing and discuss the potential of proteasome inhibitors for the modulation of antigen presentation.

CITADO POR
  1. Ren Qing-Guo, Liao Xiao-Mei, Chen Xiao-Qian, Liu Gong-Ping, Wang Jian-Zhi, Effects of tau phosphorylation on proteasome activity, FEBS Letters, 581, 7, 2007. Crossref

  2. Konstantinova Irina M., Tsimokha Anna S., Mittenberg Alexey G., , 267, 2008. Crossref

  3. Lee Sylvia, Margolin Kim, Cytokines in Cancer Immunotherapy, Cancers, 3, 4, 2011. Crossref

  4. Ding Qunxing, Dimayuga Edgardo, Keller Jeffrey N., Proteasome Regulation of Oxidative Stress in Aging and Age-Related Diseases of the CNS, Antioxidants & Redox Signaling, 8, 1-2, 2006. Crossref

  5. Alvarado-Guerri Rocío, Cabrera Carmen M., Garrido Federico, López-Nevot Miguel Ángel, TAP1 and TAP2 Polymorphisms and Their Linkage Disequilibrium With HLA-DR, -DP, and -DQ in an Eastern Andalusian Population, Human Immunology, 66, 8, 2005. Crossref

  6. Trojan Annabelle, Jay Lina M., Kasprzak Heliodor, Anthony Donald D., Trojan Jerzy, Immunotherapy of Malignant Tumors Using Antisense Anti-IGF-I Approach: Case of Glioblastoma, Journal of Cancer Therapy, 05, 07, 2014. Crossref

  7. Dohmen R. Jürgen, Willers Imke, Marques António J., Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1773, 11, 2007. Crossref

  8. Rosen Kenneth M., Moghekar Abhay, O’Brien Richard J., Activity dependent localization of synaptic NMDA receptors in spinal neurons, Molecular and Cellular Neuroscience, 34, 4, 2007. Crossref

  9. Schliehe Christopher, Schliehe Constanze, Thiry Marc, Tromsdorf Ulrich I., Hentschel Joachim, Weller Horst, Groettrup Marcus, Microencapsulation of inorganic nanocrystals into PLGA microsphere vaccines enables their intracellular localization in dendritic cells by electron and fluorescence microscopy, Journal of Controlled Release, 151, 3, 2011. Crossref

  10. Kim-Schulze Seunghee, Taback Bret, Kaufman Howard L., Cytokine Therapy for Cancer, Surgical Oncology Clinics of North America, 16, 4, 2007. Crossref

  11. Ding Qunxing, Reinacker Kristi, Dimayuga Edgardo, Nukala Vidya, Drake Jennifer, Butterfield D.Allan, Dunn Jay C., Martin Sarah, Bruce-Keller Annadora J., Keller Jeffrey N., Role of the proteasome in protein oxidation and neural viability following low-level oxidative stress, FEBS Letters, 546, 2-3, 2003. Crossref

  12. Hovav Avi-Hai, Bercovier Herve, Pseudo-rationale design of efficient TB vaccines: Lesson from the mycobacterial 27-kDa lipoprotein, Tuberculosis, 86, 3-4, 2006. Crossref

  13. Feng Xiaodong, Jiang Yuchen, Xie Liang, Jiang Lu, Li Jing, Sun Chongkui, Xu Hao, Wang Ruinan, Zhou Min, Zhou Yu, Dan Hongxia, Wang Zhiyong, Ji Ning, Deng Peng, Liao Ga, Geng Ning, Wang Yun, Zhang Dunfang, Lin Yunfeng, Ye Ling, Liang Xinhua, Li Longjiang, Luo Gang, Feng Mingye, Fang Juan, Zeng Xin, Wang Zhi, Chen Qianming, Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma, Journal of Experimental & Clinical Cancer Research, 35, 1, 2016. Crossref

  14. Chari Ajai, Hajje Daher, Case series discussion of cardiac and vascular events following carfilzomib treatment: possible mechanism, screening, and monitoring, BMC Cancer, 14, 1, 2014. Crossref

  15. Pan Yuexin, Trojan Jerzy, Guo Yajun, Anthony Donald D., Castresana Javier S., Rescue of MHC-1 Antigen Processing Machinery by Down-Regulation in Expression of IGF-1 in Human Glioblastoma Cells, PLoS ONE, 8, 3, 2013. Crossref

  16. González Yisett, Doens Deborah, Cruz Héctor, Santamaría Ricardo, Gutiérrez Marcelino, Llanes Alejandro, Fernández Patricia, A Marine Diterpenoid Modulates the Proteasome Activity in Murine Macrophages Stimulated with LPS, Biomolecules, 8, 4, 2018. Crossref

  17. Kalim Khalid W., Basler Michael, Kirk Christopher J., Groettrup Marcus, Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation, The Journal of Immunology, 189, 8, 2012. Crossref

  18. Eisenlohr Laurence C., Rothstein Jay L., Antigen Processing and Presentation, in Tumor Immunology and Cancer Vaccines, 123, 2005. Crossref

  19. Margolin Kim, Lazarus Mark, Kaufman Howard L., Cytokines in the Treatment of Cancer, in Cancer Immunotherapy, 2013. Crossref

  20. Kremer Marcel, Henn Anja, Kolb Cornelia, Basler Michael, Moebius Jacqueline, Guillaume Benoît, Leist Marcel, Van den Eynde Benoît J., Groettrup Marcus, Reduced Immunoproteasome Formation and Accumulation of Immunoproteasomal Precursors in the Brains of Lymphocytic Choriomeningitis Virus-Infected Mice, The Journal of Immunology, 185, 9, 2010. Crossref

  21. Hess Krista, Yang Yinhua, Golech Susanne, Sharov Alexei, Becker Kevin G., Weng Nan-ping, Kinetic assessment of general gene expression changes during human naive CD4+ T cell activation, International Immunology, 16, 12, 2004. Crossref

  22. Wang Yutao, Yan Kexin, Lin Jiaxing, Liu Yang, Wang Jianfeng, Li Xuejie, Li Xinxin, Hua Zhixiong, Zheng Zhenhua, Shi Jianxiu, Sun Siqing, Bi Jianbin, CD8+ T Cell Co-Expressed Genes Correlate With Clinical Phenotype and Microenvironments of Urothelial Cancer, Frontiers in Oncology, 10, 2020. Crossref

  23. Kumar Amrendra, Suryadevara Naveen Chandra, Wolf Kyle J., Wilson John T., Di Paolo Richard J., Brien James D., Joyce Sebastian, Heterotypic immunity against vaccinia virus in an HLA-B*07:02 transgenic mousepox infection model, Scientific Reports, 10, 1, 2020. Crossref

  24. Abdelbaky Salma B., Ibrahim Mayar Tarek, Samy Hebatallah, Mohamed Menatalla, Mohamed Hebatallah, Mustafa Mahmoud, Abdelaziz Moustafa M., Forrest M. Laird, Khalil Islam A., Cancer immunotherapy from biology to nanomedicine, Journal of Controlled Release, 336, 2021. Crossref

  25. Rho Jung-hyun, Qin Shuzhen, Wang Julia Y., Roehrl Michael H. A., Proteomic Expression Analysis of Surgical Human Colorectal Cancer Tissues: Up-Regulation of PSB7, PRDX1, and SRP9 and Hypoxic Adaptation in Cancer, Journal of Proteome Research, 7, 7, 2008. Crossref

  26. Demo Susan D., Kirk Christopher J., Aujay Monette A., Buchholz Tonia J., Dajee Maya, Ho Mark N., Jiang Jing, Laidig Guy J., Lewis Evan R., Parlati Francesco, Shenk Kevin D., Smyth Mark S., Sun Congcong M., Vallone Marcy K., Woo Tina M., Molineaux Christopher J., Bennett Mark K., Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome, Cancer Research, 67, 13, 2007. Crossref

  27. Chen Qinghua, Thorpe Jeffrey, Keller Jeffrey N., α-Synuclein Alters Proteasome Function, Protein Synthesis, and Stationary Phase Viability, Journal of Biological Chemistry, 280, 34, 2005. Crossref

  28. Fellerhoff Barbara, Gu Songhai, Laumbacher Barbara, Nerlich Andreas G., Weiss Elisabeth H., Glas Jürgen, Kopp Reinhard, Johnson Judith P., Wank Rudolf, The LMP7-K Allele of the Immunoproteasome Exhibits Reduced Transcript Stability and Predicts High Risk of Colon Cancer, Cancer Research, 71, 23, 2011. Crossref

  29. Siegmund Daniela, Wicovsky Andreas, Schmitz Ingo, Schulze-Osthoff Klaus, Kreuz Sebastian, Leverkus Martin, Dittrich-Breiholz Oliver, Kracht Michael, Wajant Harald, Death Receptor-Induced Signaling Pathways Are Differentially Regulated by Gamma Interferon Upstream of Caspase 8 Processing, Molecular and Cellular Biology, 25, 15, 2005. Crossref

  30. Schliehe Christopher, Bitzer Annegret, van den Broek Maries, Groettrup Marcus, Stable Antigen Is Most Effective for Eliciting CD8 + T-Cell Responses after DNA Vaccination and Infection with Recombinant Vaccinia Virus In Vivo , Journal of Virology, 86, 18, 2012. Crossref

  31. Li Yuhuan, Wang Li-Xin, Pang Puiyi, Cui Zhihua, Aung Sandra, Haley Daniel, Fox Bernard A., Urba Walter J., Hu Hong-Ming, Tumor-Derived Autophagosome Vaccine: Mechanism of Cross-Presentation and Therapeutic Efficacy, Clinical Cancer Research, 17, 22, 2011. Crossref

  32. Hovav Avi-Hai, Fishman Yolanta, Bercovier Herve, Gamma Interferon and Monophosphoryl Lipid A-Trehalose Dicorynomycolate Are Efficient Adjuvants for Mycobacterium tuberculosis Multivalent Acellular Vaccine , Infection and Immunity, 73, 1, 2005. Crossref

  33. Su Andrew I., Pezacki John P., Wodicka Lisa, Brideau Amy D., Supekova Lubica, Thimme Robert, Wieland Stefan, Bukh Jens, Purcell Robert H., Schultz Peter G., Chisari Francis V., Genomic analysis of the host response to hepatitis C virus infection, Proceedings of the National Academy of Sciences, 99, 24, 2002. Crossref

  34. Yang Yang, Liu Weiyong, Hu Dan, Su Rui, Ji Man, Huang Yuqing, Shereen Muhammad Adnan, Xu Xiaodi, Luo Zhen, Zhang Qi, Liu Fang, Wu Kailang, Liu Yingle, Wu Jianguo, Pizzato Massimo, Prasad Vinayaka R., HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation, mBio, 11, 5, 2020. Crossref

  35. Groettrup Marcus, Kirk Christopher J., Basler Michael, Proteasomes in immune cells: more than peptide producers?, Nature Reviews Immunology, 10, 1, 2010. Crossref

  36. Palmowski Michael J., Gileadi Uzi, Salio Mariolina, Gallimore Awen, Millrain Maggie, James Edward, Addey Caroline, Scott Diane, Dyson Julian, Simpson Elizabeth, Cerundolo Vincenzo, Role of Immunoproteasomes in Cross-Presentation, The Journal of Immunology, 177, 2, 2006. Crossref

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