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Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Linkage of Immune Self-Tolerance with the Positive Selection of T Cells

Volumen 19, Edición 3, 1999, 20 pages
DOI: 10.1615/CritRevImmunol.v19.i3.20
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SINOPSIS

Development and maturation of antigen-specific T cells take place in the thymus in a process dependent on recognition by the T cell antigen receptor (TCR) of endogenous self-peptides presented by several types of specialized stromal cells. Paradoxically, emerging T cells are not self-reactive, and it is commonly believed that deletion of high avidity autoreactive T cells is the principal mechanism for establishing self-tolerance. However, there is increasing evidence that the positive selection of T cells on self-peptides presented by thymic cortical epithelial cells must be linked with a process that prevents their subsequent activation when the same self-peptides are encountered in the periphery. Consequently, a higher activation threshold is established that can be overcome only with ligands of higher affinity, which would normally be foreign peptides. The molecular basis for this increase in activation threshold is unknown, but observations on differential signaling by peptide analogs, on increased TCR expression during T cell maturation and on anergy induction in the absence of costimulation provide promising leads. Linkage of self-tolerance with positive selection is a simple and evolutionary sound explanation for self/non-self discrimination and offers a framework for understanding systemic autoimmunity.

CITADO POR
  1. Paessens Lutz C., Singh Satwinder K., Fernandes Rosette J., van Kooyk Yvette, Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes, Molecular Immunology, 45, 1, 2008. Crossref

  2. Stahl Dorothea, Warm Autoimmune Hemolytic Anemia: A Clinical Model to Study Mechanisms of Immunoregulation*, Transfusion Medicine and Hemotherapy, 33, 2, 2006. Crossref

  3. Binstock T., An immune hypothesis of sexual orientation, Medical Hypotheses, 57, 5, 2001. Crossref

  4. Rubin Robert L., Kretz-Rommel Anke, Phagocyte-mediated oxidation in idiosyncratic adverse drug reactions, Current Opinion in Hematology, 8, 1, 2001. Crossref

  5. Wira Charles R, Fahey John V, Abrahams Vikki M, Rossoll Richard M, Influence of stage of the reproductive cycle and estradiol on thymus cell antigen presentation, The Journal of Steroid Biochemistry and Molecular Biology, 84, 1, 2003. Crossref

  6. Garrido-Fariña G.I., Cornejo-Cortés M.A., Martínez-Rodríguez A., Reyes-Esparza J., Alba-Hurtado F., Tórtora-Pérez J., A study of the process of apoptosis in animals infected with the contagious ecthyma virus, Veterinary Microbiology, 129, 1-2, 2008. Crossref

  7. Sporici Romeo A., Perrin Peter J., Costimulation of Memory T-Cells by ICOS: A Potential Therapeutic Target for Autoimmunity?, Clinical Immunology, 100, 3, 2001. Crossref

  8. Palu Cintia C., Linhares-Lacerda Leandra, Savino Wilson, Ribeiro-Alves Marcelo, Genetic modulation during thymocyte development an integrative approach based on microarray meta-analysis, 2015 IEEE 5th International Conference on Computational Advances in Bio and Medical Sciences (ICCABS), 2015. Crossref

  9. Rubin Robert L., Hermanson Tracee M., Plasticity in the positive selection of T cells: affinity of the selecting antigen and IL-7 affect T cell responsiveness, International Immunology, 17, 7, 2005. Crossref

  10. Kretz-Rommel Anke, Rubin Robert L., Disruption of positive selection of thymocytes causes autoimmunity, Nature Medicine, 6, 3, 2000. Crossref

  11. Stahl Dorothea, Analyse natürlicher Autoantikörper-Repertoires im Humansystem – Ein systembiologisch orientierter Ansatz zum Verständnis Immunglobulin-vermittelter Immunregulation Analysis of natural autoantibody repertoires in humans – investigation of immunoglobulin-mediated immunoregulation at the level of complex biological systems, LaboratoriumsMedizin, 29, 6, 2005. Crossref

  12. Moulian Nathalie, Truffault Frédérique, Gaudry-Talarmain Yvette Morot, Serraf Alain, Berrih-Aknin Sonia, In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation, Blood, 97, 11, 2001. Crossref

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