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Critical Reviews™ in Immunology
Factor de Impacto: 1.352 Factor de Impacto de 5 años: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v16.i2.20
pages 145-222

Immunopathogenesis of Virus Diseases Affecting the Central Nervous System

Thomas Bilzer
Institut fur Neuropathologie, Heinrich-Heine-Universitat, Postfach 101007, 40001 Dusseldorf
Lothar Stitz
lnstitut fur Impfstoffe, Bundesforschungsanstalt fur Viruskrankheiten der Tiere, Paul-Ehrlich-Str.28, 72076 Tubingen, FRG


A variety of viruses can cause diseases of the central nervous system by two different mechanisms. Cytolytic viruses exert direct effects on cells of the nervous system that result in death and cell loss. Noncytolytic viruses do not directly damage cells, but might harm cell functions in the long run. However, more common is the reaction of the immune system towards viral antigens of those noncytolytic viruses which ultimately might lead to an immunopathological disease. Several peculiarities of the central nervous system with regard to an immune reaction within this organ are discussed in the context of viral infections.

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