Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.404 Factor de Impacto de 5 años: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v32.i1.50
pages 81-95

Genetic Requirements for the Development and Differentiation of lnterleukin-17-Producing γδ T Cells

Sandra M. Hayes
Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, NY
Renee M. Laird
Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, NY

SINOPSIS

Most effector T cells are generated in the periphery following an encounter with a foreign antigen and exposure to soluble and membrane-bound mediators. There are, however, some T cell subsets, such as γδ T cells and natural killer T cells, that acquire their effector potential in the thymus before their emigration to the periphery. This developmental preprogramming enables these cells to differentiate rapidly into cytokine-producing effectors during the host immune response. This review focuses on murine interleukin (IL)-17−producing γδ T (γδ-17) cells, which have been shown, through their early production of IL-17, to have a critical role in multiple infectious and autoimmune diseases. Specifically, we discuss what is currently known about the genetic requirements for their generation and compare it with what is known about that of the more extensively studied IL-17−producing helper T (Thl7) cells. Based on this comparison, we propose a model for murine γδ-17 development and differentiation.


Articles with similar content:

iNKT-Cell Responses to Glycolipids
Critical Reviews™ in Immunology, Vol.25, 2005, issue 3
Luc Van Kaer, Vrajesh V. Parekh, Michael T. Wilson
Autoimmunity and the Immunotherapy of Cancer: Targeting the "Self" to Destroy the "Other"
Critical Reviews™ in Immunology, Vol.20, 2000, issue 6
Nicholas P. Restifo, Willem W. Overwijk
Compartmentalization g/d T Cells and Their Putative Role in Mucosal Immunity
Critical Reviews™ in Immunology, Vol.23, 2003, issue 5-6
Wolfgang Holtmeier
MHC-Restricted B-Cell Antigen Presentation in Memory B-Cell Maintenance and Differentiation
Critical Reviews™ in Immunology, Vol.27, 2007, issue 1
Michiko Shimoda, Pandelakis A. Koni
Crosstalk between T Lymphocytes and Dendritic Cells
Critical Reviews™ in Immunology, Vol.32, 2012, issue 2
Marie Tourret, Claire Hivroz, Karine Chemin, Armelle Bohineust