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Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Which Immune Cells Matter? The Immunopathogenesis of Multiple Sclerosis

Volumen 33, Edición 4, 2013, pp. 283-306
DOI: 10.1615/CritRevImmunol.2013007453
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Bieke Broux
Hasselt University, Biomedical Research Institute and transnationale Universiteit Limburg, School of Life Sciences, 3590 Diepenbeek, Belgium
Piet Stinissen
Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium
Niels Hellings
Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium

SINOPSIS

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is believed to be immune-mediated. While CD4+ T cells have been the main suspects for years, there is ample evidence that other immune cells (including those of the innate immune system) play a contributing or regulating role in this disease. After a general introduction, this review focuses on different immune cell subsets implicated in MS pathogenesis and on current and future possibilities to target them for therapeutic use.

PALABRAS CLAVE: adaptive immune system, genetic predisposition, innate immune system, multiple sclerosis, pathology, therapy
CITADO POR

  1. Liu Xin, Zhou Qingqing, Ji Zhenyu, Fu Guo, Li Yi, Zhang Xiaobei, Shi Xiaofang, Wang Ting, Kang Qiaozhen, Protein 4.1R attenuates autoreactivity in experimental autoimmune encephalomyelitis by suppressing CD4+ T cell activation, Cellular Immunology, 292, 1-2, 2014. Crossref

  2. Eriksen Agnete Bratsberg, Berge Tone, Gustavsen Marte Wendel, Leikfoss Ingvild Sørum, Bos Steffan Daniel, Spurkland Anne, Harbo Hanne F., Blomhoff Heidi Kiil, Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing–remitting multiple sclerosis, Journal of Neuroimmunology, 278, 2015. Crossref

  3. Aharoni Rina, Immunomodulation neuroprotection and remyelination – The fundamental therapeutic effects of glatiramer acetate: A critical review, Journal of Autoimmunity, 54, 2014. Crossref

  4. Holley Janet E., Bremer Edwin, Kendall Alexandra C., de Bruyn Marco, Helfrich Wijnand, Tarr Joanna M., Newcombe Jia, Gutowski Nicholas J., Eggleton Paul, CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination, Multiple Sclerosis and Related Disorders, 3, 5, 2014. Crossref

  5. Janssens Kris, Van den Haute Chris, Baekelandt Veerle, Lucas Sophie, van Horssen Jack, Somers Veerle, Van Wijmeersch Bart, Stinissen Piet, Hendriks Jerome J.A., Slaets Helena, Hellings Niels, Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis, Brain, Behavior, and Immunity, 45, 2015. Crossref

  6. Ayazpoor Ute, Immunologie der MS: Komplizierte T-Zell-Interaktionen, DNP - Der Neurologe und Psychiater, 15, 5, 2014. Crossref

  7. Chiurchiù Valerio, Orlacchio Antonio, Maccarrone Mauro, Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases, Oxidative Medicine and Cellular Longevity, 2016, 2016. Crossref

  8. Broux Bieke, Gowing Elizabeth, Prat Alexandre, Glial regulation of the blood-brain barrier in health and disease, Seminars in Immunopathology, 37, 6, 2015. Crossref

  9. Claes Nele, Fraussen Judith, Stinissen Piet, Hupperts Raymond, Somers Veerle, B Cells Are Multifunctional Players in Multiple Sclerosis Pathogenesis: Insights from Therapeutic Interventions, Frontiers in Immunology, 6, 2015. Crossref

  10. Maltby Vicki E., Graves Moira C., Lea Rodney A., Benton Miles C., Sanders Katherine A., Tajouri Lotti, Scott Rodney J., Lechner-Scott Jeannette, Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients, Clinical Epigenetics, 7, 1, 2015. Crossref

  11. Janssens Kris, Slaets Helena, Hellings Niels, Immunomodulatory properties of the IL-6 cytokine family in multiple sclerosis, Annals of the New York Academy of Sciences, 1351, 1, 2015. Crossref

  12. Janssens Kris, Maheshwari Anurag, Van den Haute Chris, Baekelandt Veerle, Stinissen Piet, Hendriks Jerome J. A., Slaets Helena, Hellings Niels, Oncostatin M protects against demyelination by inducing a protective microglial phenotype, Glia, 63, 10, 2015. Crossref

  13. Vanmierlo Tim, Bogie Jeroen F.J., Mailleux Jo, Vanmol Jasmine, Lütjohann Dieter, Mulder Monique, Hendriks Jerome J.A., Plant sterols: Friend or foe in CNS disorders?, Progress in Lipid Research, 58, 2015. Crossref

  14. Cardoso Bárbara Rita, Roberts Blaine R., Bush Ashley I., Hare Dominic J., Selenium, selenoproteins and neurodegenerative diseases, Metallomics, 7, 8, 2015. Crossref

  15. Bos Steffan D., Page Christian M., Andreassen Bettina K., Elboudwarej Emon, Gustavsen Marte W., Briggs Farren, Quach Hong, Leikfoss Ingvild S., Bjølgerud Anja, Berge Tone, Harbo Hanne F., Barcellos Lisa F., Ting Angela H, Genome-Wide DNA Methylation Profiles Indicate CD8+ T Cell Hypermethylation in Multiple Sclerosis, PLOS ONE, 10, 3, 2015. Crossref

  16. O'Sullivan Sinead, Dev Kumlesh K., Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases, Neuropharmacology, 113, 2017. Crossref

  17. Claes Nele, Dhaeze Tessa, Fraussen Judith, Broux Bieke, Van Wijmeersch Bart, Stinissen Piet, Hupperts Raymond, Hellings Niels, Somers Veerle, Derfuss Tobias, Compositional Changes of B and T Cell Subtypes during Fingolimod Treatment in Multiple Sclerosis Patients: A 12-Month Follow-Up Study, PLoS ONE, 9, 10, 2014. Crossref

  18. Bos S. D., Berge T., Celius E. G., Harbo H. F., From genetic associations to functional studies in multiple sclerosis, European Journal of Neurology, 23, 5, 2016. Crossref

  19. Sanders Katherine A., Benton Miles C., Lea Rod A., Maltby Vicki E., Agland Susan, Griffin Nathan, Scott Rodney J., Tajouri Lotti, Lechner-Scott Jeannette, Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells, Clinical Epigenetics, 8, 1, 2016. Crossref

  20. Shrestha Bandana, Jiang Xi, Ge Shujun, Paul Debayon, Chianchiano Peter, Pachter Joel S., Spatiotemporal resolution of spinal meningeal and parenchymal inflammation during experimental autoimmune encephalomyelitis, Neurobiology of Disease, 108, 2017. Crossref

  21. Donders Raf, Vanheusden Marjan, Bogie Jeroen F. J., Ravanidis Stylianos, Thewissen Kristof, Stinissen Piet, Gyselaers Wilfried, Hendriks Jerome J. A., Hellings Niels, Human Wharton's Jelly-Derived Stem Cells Display Immunomodulatory Properties and Transiently Improve Rat Experimental Autoimmune Encephalomyelitis, Cell Transplantation, 24, 10, 2015. Crossref

  22. TAHA SAFA, ALJISHI MUNA, ALSHAROQI ISA, BAKHIET MOIZ, Differential upregulation of the hypothetical transmembrane protein 66 (TMEM66) in multiple sclerosis patients with potential inflammatory response, Biomedical Reports, 3, 1, 2015. Crossref

  23. Peeters Liesbet M., Vanheusden Marjan, Somers Veerle, Van Wijmeersch Bart, Stinissen Piet, Broux Bieke, Hellings Niels, Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression, Frontiers in Immunology, 8, 2017. Crossref

  24. Cardamone Giulia, Paraboschi Elvezia, Soldà Giulia, Duga Stefano, Saarela Janna, Asselta Rosanna, Genetic Association and Altered Gene Expression of CYBB in Multiple Sclerosis Patients, Biomedicines, 6, 4, 2018. Crossref

  25. Duarte-Silva Eduardo, Araújo Shyrlene Meiry da Rocha, Oliveira Wilma Helena, Lós Deniele Bezerra de, França Maria Eduarda Rocha de, Bonfanti Amanda Pires, Peron Gabriela, Thomaz Livia de Lima, Verinaud Liana, Nunes Ana Karolina de Santana, Peixoto Christina Alves, Sildenafil ameliorates EAE by decreasing apoptosis in the spinal cord of C57BL/6 mice, Journal of Neuroimmunology, 321, 2018. Crossref

  26. Gharagozloo Marjan, Mahmoud Shaimaa, Simard Camille, Mahvelati Tara, Amrani Abdelaziz, Gris Denis, The Dual Immunoregulatory function of Nlrp12 in T Cell-Mediated Immune Response: Lessons from Experimental Autoimmune Encephalomyelitis, Cells, 7, 9, 2018. Crossref

  27. Dhaeze Tessa, Peelen Evelyn, Hombrouck Anneleen, Peeters Liesbet, Van Wijmeersch Bart, Lemkens Nele, Lemkens Peter, Somers Veerle, Lucas Sophie, Broux Bieke, Stinissen Piet, Hellings Niels, Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis, The Journal of Immunology, 195, 3, 2015. Crossref

  28. Maltby Vicki E., Lea Rodney A., Burnard Sean, Xavier Alexandre, Van Cao Thao, White Nicole, Kennedy Daniel, Groen Kira, Sanders Katherine A., Seeto Rebecca, Bray Samara, Gresle Melissa, Laverick Louise, Butzkueven Helmut, Scott Rodney J., Lechner-Scott Jeannette, Epigenetic differences at the HTR2A locus in progressive multiple sclerosis patients, Scientific Reports, 10, 1, 2020. Crossref

  29. Broux Bieke, Zandee Stephanie, Gowing Elizabeth, Charabati Marc, Lécuyer Marc-André, Tastet Olivier, Hachehouche Lamia, Bourbonnière Lyne, Ouimet Jean-Philippe, Lemaitre Florent, Larouche Sandra, Cayrol Romain, Bouthillier Alain, Moumdjian Robert, Lahav Boaz, Poirier Josée, Duquette Pierre, Arbour Nathalie, Peelen Evelyn, Prat Alexandre, Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function, Neurology - Neuroimmunology Neuroinflammation, 7, 6, 2020. Crossref

  30. Jalaiei Abbas, Asadi Mohammad Reza, Sabaie Hani, Dehghani Hossein, Gharesouran Jalal, Hussen Bashdar Mahmud, Taheri Mohammad, Ghafouri-Fard Soudeh, Rezazadeh Maryam, Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review, Frontiers in Immunology, 12, 2021. Crossref

  31. Stoopler Eric T., McGarvey Michael L., Neurologic Diseases, in Burket's Oral Medicine, 2021. Crossref

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