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Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Eosinophils, Pin1 and the Response to Respiratory Viral Infection and Allergic Stimuli

Volumen 39, Edición 2, 2019, pp. 135-149
DOI: 10.1615/CritRevImmunol.2019031697
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SINOPSIS

Eosinophils (Eos) are prominent inflammatory cells found in the sputum, airways, and airway walls during and after exacerbations of allergic asthma. These cells are potent secretors of a wide array of cytotoxic granule proteins, cytokines, and lipid mediators involved in the initiation and maintenance of the Th2-type inflammatory reaction. Even though respiratory viral and bacterial infections are known risk factors contributing to severity and prognosis, the induction of anti-microbial Th1 type responses can offset allergic Th2 responses. Emerging evidence suggests that the prolyl isomerase Pin1 plays important roles in both Th1 and Th2 immunity in the lung and especially during allergic disease. In this review, we summarize recent findings related to the role of Pin1 in the regulation of Eos differentiation, survival, migration, cytokine expression, and antiviral immunity in asthma.

PALABRAS CLAVE: eosinophils, asthma, virus, allergy, Pin1, TLR7
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CITADO POR
  1. Fagiani Francesca, Vlachou Marieva, Di Marino Daniele, Canobbio Ilaria, Romagnoli Alice, Racchi Marco, Govoni Stefano, Lanni Cristina, Pin1 as Molecular Switch in Vascular Endothelium: Notes on Its Putative Role in Age-Associated Vascular Diseases, Cells, 10, 12, 2021. Crossref

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