Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Therapeutic Drug Carrier Systems
Factor de Impacto: 2.9 Factor de Impacto de 5 años: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X

Volumen 37, 2020 Volumen 36, 2019 Volumen 35, 2018 Volumen 34, 2017 Volumen 33, 2016 Volumen 32, 2015 Volumen 31, 2014 Volumen 30, 2013 Volumen 29, 2012 Volumen 28, 2011 Volumen 27, 2010 Volumen 26, 2009 Volumen 25, 2008 Volumen 24, 2007 Volumen 23, 2006 Volumen 22, 2005 Volumen 21, 2004 Volumen 20, 2003 Volumen 19, 2002 Volumen 18, 2001 Volumen 17, 2000 Volumen 16, 1999 Volumen 15, 1998 Volumen 14, 1997 Volumen 13, 1996 Volumen 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v19.i1.10
72 pages

Pluronic® Block Copolymers in Drug Delivery: from Micellar Nanocontainers to Biological Response Modifiers

Alexander V. Kabanov
College of Pharmacy, Department of Pharmaceutical Sciences, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA
Valery Yu. Alakhov
Supratek Pharma Inc., 531 Blvd. des Prairies, Building 18, Laval, Quebec, Canada H7V 1B7


Pluronicв block copolymers are recognized pharmaceutical excipients listed in the US and British Pharmacopoeia. The incorporation of drugs into Pluronic micelles results in increased solubility and stability of drugs. Consequently, the micelles are used for delivery of drugs in the body. Pluronic unimers sensitize multidrug-resistant cells by inhibiting drug efflux transporters. This allows for the development of formulations for the treatment of multidrug-resistant and metastatic tumors. Furthermore, these formulations can be used to enhance brain and oral bioavailability of various drugs. Finally, Pluronic formulations were shown to enhance transgene expression in the body. This opens new possibilities for the use of Pluronic in gene therapies.

Articles with similar content:

Self-Emulsifying Drug Delivery System (SEDDS): An Emerging Dosage Form to Improve the Bioavailability of Poorly Absorbed Drugs
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.37, 2020, issue 4
Pradeep Mishra, Meenakshi Bajpai, Sonia Singh
Lipid-Based Cochleates: A Promising Formulation Platform for Oral and Parenteral Delivery of Therapeutic Agents
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 1
Emilio Squillante, III, Kwon H. Kim, Ravi Rao
Insight on Multidrug Resistance and Nanomedicine Approaches to Overcome MDR
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.37, 2020, issue 5
Wei He, Lifang Yin, Imran Shair Mohammad
Bioconjugates: Harnessing Potential for Effective Therapeutics
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 2
Piush Khare, Nitin K. Jain, Aviral Jain, Vandana Soni, Arvind Gulbake, Sanjay Kumar Jain
Chromatin Domains and Territories: Flexibly Rigid
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 1&2
Sergey V. Razin, Yegor S. Vassetzky, Alan Hair, Andrei Petrov