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Critical Reviews™ in Therapeutic Drug Carrier Systems
Factor de Impacto: 2.9 Factor de Impacto de 5 años: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v29.i2.20
pages 149-182

Drug-Loaded PLGA Nanoparticles for Oral Administration: Fundamental Issues and Challenges Ahead

Gaurav Kumar
Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai-410210, India
Nusrat Shafiq
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India
Samir Malhotra
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India

SINOPSIS

Drug-loaded polylactide-co-glycolide (PLGA) nanoparticles have been extensively studied and have a practical impact on drug delivery. Many PLGA-based nanoformulations have reached different stages of preclinical development; however, they present distinct challenges for researchers. This review discusses some of the challenges and issues involved in selecting drug and polymer combinations for encapsulation, aggregation of nanoparticles during characterization in in vitro studies, sterilization, and long-term stability of drug-loaded nanoparticles. We include recommendations to overcome these challenges.