Publicado 6 números por año
ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X
Indexed in
Liposome-Mediated Drug Targeting in Topical and Regional Therapies
SINOPSIS
Liposome-mediated drug targeting is reviewed in four major categories of topical and regional therapies: wounds and burns, ocular, intraperitoneal, and pulmonary. A survey of the data in the field is preceded by definitions of carrier-mediated drug targeting, in particular for topical and regional treatments. The ability of liposomes to meet essential requirements for task performance and liposome surface-modification as the major approach to endow liposomes with targeting abilities are reviewed. Analysis of current findings in the field shows that (1) most studies explored regular liposomes that were unable to meet the essential requirements for targeting and (2) in vivo drug targeting in topical and regional therapies has been achieved rarely and seldom attempted, yet there are encouraging indications from a few studies that using surface-modified liposomes such targeting is feasible. Both established and novel liposomal systems attest to this feasibility and point out future directions. The former can be found by revisiting immunoliposomes that were initially designed for systemic administration but might well fit topical and regional cases. The latter is exemplified by bioadhesive liposomes, designed specifically for topical/regional therapies. It is concluded that careful implementation of such approaches could be successful for the achievement of liposome-mediated drug targeting in topical and regional therapies.
-
Peer Dan, Margalit Rimona, Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models, International Journal of Cancer, 108, 5, 2004. Crossref
-
Tanrıverdi Sakine Tuncay, Özer Özgen, Novel topical formulations of Terbinafine-HCl for treatment of onychomycosis, European Journal of Pharmaceutical Sciences, 48, 4-5, 2013. Crossref
-
Maestrelli F., González-Rodríguez M.L., Rabasco A.M., Ghelardini C., Mura P., New “drug-in cyclodextrin-in deformable liposomes” formulations to improve the therapeutic efficacy of local anaesthetics, International Journal of Pharmaceutics, 395, 1-2, 2010. Crossref
-
Whateley Tony L., Literature Alerts, Drug Delivery, 3, 3, 1996. Crossref
-
Peer Dan, Florentin Anat, Margalit Rimona, Hyaluronan is a key component in cryoprotection and formulation of targeted unilamellar liposomes, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1612, 1, 2003. Crossref
-
Manosroi A, Kongkaneramit L, Manosroi J, Stability and transdermal absorption of topical amphotericin B liposome formulations, International Journal of Pharmaceutics, 270, 1-2, 2004. Crossref
-
Yerushalmi Noga, Margalit Rimona, Hyaluronic Acid-Modified Bioadhesive Liposomes as Local Drug Depots: Effects of Cellular and Fluid Dynamics on Liposome Retention at Target Sites, Archives of Biochemistry and Biophysics, 349, 1, 1998. Crossref
-
Elron-Gross Inbar, Glucksam Yifat, Margalit Rimona, Liposomal dexamethasone–diclofenac combinations for local osteoarthritis treatment, International Journal of Pharmaceutics, 376, 1-2, 2009. Crossref
-
Zhou Xiangzhu, Dong Shuli, Hao Jingcheng, Phase behavior and rheological properties of lecithin/TTAOH/H2O mixtures, Colloid and Polymer Science, 289, 13, 2011. Crossref
-
Pierre Maria Bernadete Riemma, dos Santos Miranda Costa Irina, Liposomal systems as drug delivery vehicles for dermal and transdermal applications, Archives of Dermatological Research, 303, 9, 2011. Crossref
-
Elron-Gross Inbar, Glucksam Yifat, Melikhov Dina, Margalit Rimona, Cyclooxygenase inhibition by diclofenac formulated in bioadhesive carriers, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1778, 4, 2008. Crossref
-
Fischer Sharon, Arad Aya, Margalit Rimona, Lipsome-formulated enzymes for organophosphate scavenging: Butyrylcholinesterase and Demeton-S, Archives of Biochemistry and Biophysics, 434, 1, 2005. Crossref
-
Babincová M, Sourivong P, Chorvát D, Babinec P, Laser triggered drug release from magnetoliposomes, Journal of Magnetism and Magnetic Materials, 194, 1-3, 1999. Crossref
-
Kawakami Shigeru, Munakata Chie, Fumoto Shintaro, Yamashita Fumiyoshi, Hashida Mitsuru, Novel Galactosylated Liposomes for Hepatocyte‐Selective Targeting of Lipophilic Drugs, Journal of Pharmaceutical Sciences, 90, 2, 2001. Crossref
-
Bragagni Marco, Maestrelli Francesca, Mennini Natascia, Ghelardini Carla, Mura Paola, Liposomal formulations of prilocaine: effect of complexation with hydroxypropyl-ß-cyclodextrin on drug anesthetic efficacy, Journal of Liposome Research, 20, 4, 2010. Crossref
-
Schumacher Ilana, Margalit Rimona, Liposome-Encapsulated Ampicillin: Physicochemical and Antibacterial Properties, Journal of Pharmaceutical Sciences, 86, 5, 1997. Crossref
-
Mura Paola, Capasso Gaetano, Maestrelli Francesca, Furlanetto Sandra, Optimization of Formulation Variables of Benzocaine Liposomes using Experimental Design, Journal of Liposome Research, 18, 2, 2008. Crossref
-
Zhong J., Dai L. C., Targeting Liposomal Nanomedicine to Cancer Therapy, Technology in Cancer Research & Treatment, 11, 5, 2012. Crossref
-
Bakonyi Mónika, Berkó Szilvia, Budai-Szűcs Mária, Kovács Anita, Csányi Erzsébet, DSC for evaluating the encapsulation efficiency of lidocaine-loaded liposomes compared to the ultracentrifugation method, Journal of Thermal Analysis and Calorimetry, 130, 3, 2017. Crossref
-
Kaidanovich-Beilin Oksana, Eldar-Finkelman Hagit, Peptides Targeting Protein Kinases: Strategies and Implications, Physiology, 21, 6, 2006. Crossref
-
Reddy K Rajender, Controlled-Release, Pegylation, Liposomal Formulations: New Mechanisms in the Delivery of Injectable Drugs, Annals of Pharmacotherapy, 34, 7-8, 2000. Crossref
-
Chetoni Patrizia, Rossi Sara, Burgalassi Susi, Monti Daniela, Mariotti Silvia, Saettone M. Fabrizio, Comparison of Liposome-Encapsulated Acyclovir with Acyclovir Ointment: Ocular Pharmacokinetics in Rabbits, Journal of Ocular Pharmacology and Therapeutics, 20, 2, 2004. Crossref
-
Hattori Yoshiyuki, Kawakami Shigeru, Yamashita Fumiyoshi, Hashida Mitsuru, Controlled biodistribution of galactosylated liposomes and incorporated probucol in hepatocyte-selective drug targeting, Journal of Controlled Release, 69, 3, 2000. Crossref
-
Darvishi Mohammad, Farahani Shahrzad, Haeri Azadeh, Moxifloxacin-Loaded Lipidic Nanoparticles for Antimicrobial Efficacy, Current Pharmaceutical Design, 27, 1, 2021. Crossref