Publicado 6 números por año
ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X
Indexed in
Pancreatic Cancer: Recent Advances in Nanoformulation-Based Therapies
SINOPSIS
Pancreatic cancer is the fourth leading cause of death in the United States and has a 5-year life expectancy of ~8%. Currently, only a few drugs have been approved by the United States Food and Drug Administration for pancreatic cancer treatment. Despite available drug therapy and ongoing clinical investigations, the high prevalence and mortality associated with pancreatic cancer mean that there is an unmet chemopreventive and therapeutic need. From ongoing studies with various novel formulations, it is evident that the development of smart drug delivery systems will improve delivery of drug cargo to the pancreatic target site to ensure and enhance the therapeutic/chemoprevention efficacy of existing drugs and newly designed drugs in the future. With this in view, nanotechnology is emerging as a promising avenue to enhance drug delivery to the pancreas via both passive and active targeting mechanisms. Research in this field has grown extensively over the past decade, as is evident from available scientific literature. This review summarizes the recent advances that have brought nanotechnology-based formulations to the forefront of pancreatic cancer treatment.
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Desai Preshita, Thakkar Arvind, Ann David, Wang Jeffrey, Prabhu Sunil, Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancer, Drug Delivery and Translational Research, 9, 3, 2019. Crossref
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Etman Samar M., Abdallah Ossama Y., Elnaggar Yosra S.R., Novel fucoidan based bioactive targeted nanoparticles from Undaria Pinnatifida for treatment of pancreatic cancer, International Journal of Biological Macromolecules, 145, 2020. Crossref
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Tan Bee Ling, Norhaizan Mohd Esa, Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer, Molecules, 24, 14, 2019. Crossref
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Desai Preshita, Thumma Naga Jyothi, Wagh Pushkaraj Rajendra, Zhan Shuyu, Ann David, Wang Jeffrey, Prabhu Sunil, Cancer Chemoprevention Using Nanotechnology-Based Approaches, Frontiers in Pharmacology, 11, 2020. Crossref
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Desai Preshita, Wang Kevin Zhijun, Ann David, Wang Jeffrey, Prabhu Sunil, Efficacy and Pharmacokinetic Considerations of Loratadine Nanoformulations and its Combinations for Pancreatic Cancer Chemoprevention, Pharmaceutical Research, 37, 2, 2020. Crossref
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Hussain Arif, Hasan Anwarul, Babadaei Mohammad Mahdi Nejadi, Bloukh Samir Haj, Edis Zehra, Rasti Behnam, Sharifi Majid, Falahati Mojtaba, Application of gelatin nanoconjugates as potential internal stimuli-responsive platforms for cancer drug delivery, Journal of Molecular Liquids, 318, 2020. Crossref
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Demirtürk Nurbanu, Bilensoy Erem, Nanocarriers targeting the diseases of the pancreas, European Journal of Pharmaceutics and Biopharmaceutics, 170, 2022. Crossref