Publicado 6 números por año
ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X
Indexed in
Recent Advances in Self-Emulsifying Drug Delivery Systems (SEDDS)
SINOPSIS
One of the biggest challenges confronting the contemporary drug delivery science today is to improve on the oral bioavailability of a vast number of drugs exhibiting poor and inconsistent gastrointestinal absorption. Self-emulsifying drug delivery systems (SEDDS) have been proved as highly useful technological innovations to surmount such bioavailability hiccups by virtue of their diminutive globule size, higher solubilization tendency for hydro-phobic drugs, robust formulation advantages, and easier scalability in the industrial milieu. Besides, these systems are also known to inhibit the P-glycoprotein (P-gp) efflux, reduce metabolism by gut Cytochrome P-450 enzymes, and circumnavigate the hepatic first-pass effect, facilitating absorption of drugs via intestinal lymphatic pathways. In the last two decades, the phenomenal success of SEDDS as a potential tool for oral delivery of drugs has extrapolated their applications to non-oral delivery also. Various innovative approaches and patented techniques have been reported on formulation of diverse oral and non-oral self-emulsifying (SE) systems not only of various synthetic and semisynthetic drugs, but also of several phytopharmaceuticals, nutraceuticals, and biological macromolecules. Of late, an escalating number of reports have been pouring in on special types of SE systems, mostly nanosized, employing functional excipients such as polar lipids, phospholipids, cellulosic polymer, diblock polymers, etc. This review paper provides an updated bird's-eye view account on the publications and patents of such novel SE approaches for use in both oral and non-oral therapeutics. Providing a relatively pithy overview, this paper thus endeavors to act as a repertoire of knowledge and know-how to guide the product development scientist in formulating variegated SE systems.
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Hassan Tamer H., Metz Hendrik, Mäder Karsten, Novel semisolid SNEDDS based on PEG-30-dipolyhydroxystearate: Development and characterization, International Journal of Pharmaceutics, 477, 1-2, 2014. Crossref
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Singh Gurinder, Pai Roopa S., Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS, Journal of Controlled Release, 194, 2014. Crossref
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Sandhu Premjeet Singh, Beg Sarwar, Mehta Farhad, Singh Bhupinder, Trivedi Piyush, Novel dietary lipid-based self-nanoemulsifying drug delivery systems of paclitaxel with p-gp inhibitor: implications on cytotoxicity and biopharmaceutical performance, Expert Opinion on Drug Delivery, 12, 11, 2015. Crossref
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Sharma Gajanand, Beg Sarwar, Thanki Kaushik, Katare O. P., Jain Sanyog, Kohli Kanchan, Singh Bhupinder, Systematic development of novel cationic self-nanoemulsifying drug delivery systems of candesartan cilexetil with enhanced biopharmaceutical performance, RSC Advances, 5, 87, 2015. Crossref
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Beg Sarwar, Sharma Gajanand, Thanki Kaushik, Jain Sanyog, Katare O.P., Singh Bhupinder, Positively charged self-nanoemulsifying oily formulations of olmesartan medoxomil: Systematic development, in vitro, ex vivo and in vivo evaluation, International Journal of Pharmaceutics, 493, 1-2, 2015. Crossref
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Qadir Abdul, Faiyazuddin M.D., Talib Hussain M.D., Alshammari Thamir M., Shakeel Faiyaz, Critical steps and energetics involved in a successful development of a stable nanoemulsion, Journal of Molecular Liquids, 214, 2016. Crossref
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Rodrigues Ligia R., Microbial surfactants: Fundamentals and applicability in the formulation of nano-sized drug delivery vectors, Journal of Colloid and Interface Science, 449, 2015. Crossref
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Hassan Tamer H., Mäder Karsten, Novel semisolid SNEDDS based on PEG-30-di-(polyhydroxystearate): Progesterone incorporation and in vitro digestion, International Journal of Pharmaceutics, 486, 1-2, 2015. Crossref
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Garg Babita, Katare O.P., Beg Sarwar, Lohan Shikha, Singh Bhupinder, Systematic development of solid self-nanoemulsifying oily formulations (S-SNEOFs) for enhancing the oral bioavailability and intestinal lymphatic uptake of lopinavir, Colloids and Surfaces B: Biointerfaces, 141, 2016. Crossref
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Tripathi Chandra Bhushan, Beg Sarwar, Kaur Ripandeep, Shukla Geeta, Bandopadhyay Shantanu, Singh Bhupinder, Systematic development of optimized SNEDDS of artemether with improved biopharmaceutical and antimalarial potential, Drug Delivery, 23, 9, 2016. Crossref
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Singh Bhupinder, Garg Babita, Kaur Ranjot, Jain Atul, Kumar Rajendra, Katare O P, Self-nanoemulsifying systems for oral bioavailability enhancement, in Fabrication and Self-Assembly of Nanobiomaterials, 2016. Crossref
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Rezhdo Oljora, Speciner Lauren, Carrier Rebecca, Lipid-associated oral delivery: Mechanisms and analysis of oral absorption enhancement, Journal of Controlled Release, 240, 2016. Crossref
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Beg Sarwar, Katare O.P., Saini Sumant, Garg Babita, Khurana Rajneet Kaur, Singh Bhupinder, Solid self-nanoemulsifying systems of olmesartan medoxomil: Formulation development, micromeritic characterization, in vitro and in vivo evaluation, Powder Technology, 294, 2016. Crossref
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Recharla Neeraja, Riaz Muhammad, Ko Sanghoon, Park Sungkwon, Novel technologies to enhance solubility of food-derived bioactive compounds: A review, Journal of Functional Foods, 39, 2017. Crossref
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Tripathi Chandra Bhushan, Gupta Neha, Kumar Pranesh, Singh Ashok Kumar, Raj Vinit, Parashar Poonam, Singh Mahendra, Kanoujia Jovita, Arya Malti, Saraf Shubhini A, Saha Sudipta, ω-3 Fatty Acid Synergized Novel Nanoemulsifying System for Rosuvastatin Delivery: In Vitro and In Vivo Evaluation, AAPS PharmSciTech, 19, 3, 2018. Crossref
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Rezhdo Oljora, Di Maio Selena, Le Peisi, Littrell Kenneth C., Carrier Rebecca L., Chen Sow-Hsin, Characterization of colloidal structures during intestinal lipolysis using small-angle neutron scattering, Journal of Colloid and Interface Science, 499, 2017. Crossref
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Kumar Bimlesh, Garg Varun, Singh Saurabh, Pandey Narendra Kumar, Bhatia Amit, Prakash T., Gulati Monica, Singh Sachin Kumar, Impact of spray drying over conventional surface adsorption technique for improvement in micromeritic and biopharmaceutical characteristics of self-nanoemulsifying powder loaded with two lipophilic as well as gastrointestinal labile drugs, Powder Technology, 326, 2018. Crossref
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Beg Sarwar, Katare O.P., Singh Bhupinder, Formulation by design approach for development of ultrafine self-nanoemulsifying systems of rosuvastatin calcium containing long-chain lipophiles for hyperlipidemia management, Colloids and Surfaces B: Biointerfaces, 159, 2017. Crossref
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Vasconcelos Teófilo, Marques Sara, Sarmento Bruno, Measuring the emulsification dynamics and stability of self-emulsifying drug delivery systems, European Journal of Pharmaceutics and Biopharmaceutics, 123, 2018. Crossref
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Garg Babita, Beg Sarwar, Kaur Ranjot, Kumar Rajendra, Katare Om Prakash, Singh Bhupinder, Long-chain triglycerides-based self-nanoemulsifying oily formulations (SNEOFs) of darunavir with improved lymphatic targeting potential, Journal of Drug Targeting, 26, 3, 2018. Crossref
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Joshi Ruthvika, Kulkarni Yogesh A., Wairkar Sarika, Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update, Life Sciences, 215, 2018. Crossref
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Rajesh Sarvi Yadav, Singh Sachin Kumar, Pandey Narendra Kumar, Sharma Parth, Bawa Palak, Kumar Bimlesh, Gulati Monica, Jain Subheet Kumar, Gowthamarajan Kuppusamy, Singh Saurabh, Impact of various solid carriers and spray drying on pre/post compression properties of solid SNEDDS loaded with glimepiride: in vitro-ex vivo evaluation and cytotoxicity assessment, Drug Development and Industrial Pharmacy, 44, 7, 2018. Crossref
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Silva Luis Antonio D., Almeida Susana L., Alonso Ellen C.P., Rocha Priscila B.R., Martins Felipe T., Freitas Luís A.P., Taveira Stephania F., Cunha-Filho Marcilio S.S., Marreto Ricardo N., Preparation of a solid self-microemulsifying drug delivery system by hot-melt extrusion, International Journal of Pharmaceutics, 541, 1-2, 2018. Crossref
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Mahmood Arshad, Bernkop-Schnürch Andreas, SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs, Advanced Drug Delivery Reviews, 142, 2019. Crossref
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Xue Xu, Cao Mengyuan, Ren Lili, Qian Yiwen, Chen Guoguang, Preparation and Optimization of Rivaroxaban by Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Enhanced Oral Bioavailability and No Food Effect, AAPS PharmSciTech, 19, 4, 2018. Crossref
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Khurana Rajneet Kaur, Gaspar Balan Louis, Welsby Gail, Katare O. P., Singh Kamalinder K., Singh Bhupinder, Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems, Drug Delivery and Translational Research, 8, 3, 2018. Crossref
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Sharma Parth, Singh Sachin Kumar, Pandey Narendra Kumar, Rajesh Sarvi Yadav, Bawa Palak, Kumar Bimlesh, Gulati Monica, Singh Saurabh, Verma Surajpal, Yadav Ankit Kumar, Wadhwa Sheetu, Jain Subheet Kumar, Gowthamarajan Kuppusamy, Malik Adil Hussain, Gupta Suksham, Khursheed Rubiya, Impact of solid carriers and spray drying on pre/post-compression properties, dissolution rate and bioavailability of solid self-nanoemulsifying drug delivery system loaded with simvastatin, Powder Technology, 338, 2018. Crossref
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Jain Atul, Kaur Rajpreet, Beg Sarwar, Kushwah Varun, Jain Sanyog, Singh Bhupinder, Novel cationic supersaturable nanomicellar systems of raloxifene hydrochloride with enhanced biopharmaceutical attributes, Drug Delivery and Translational Research, 8, 3, 2018. Crossref
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Pal Ravi Raj, Parashar Poonam, Singh Indu, Saraf Shubhini A., Tamanu oil potentiated novel sericin emulgel of levocetirizine: repurposing for topical delivery against DNCB-induced atopic dermatitis, QbD based development and in vivo evaluation, Journal of Microencapsulation, 36, 5, 2019. Crossref
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Bindhani Sabitri, Mohapatra S., Kar R.K., Self Emulsifying Drug Delivery System: A Recent Approach, Asian Journal of Chemistry, 31, 4, 2019. Crossref
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Gudiña Eduardo J., Rodrigues Lígia R., Research and Production of Biosurfactants for the Food Industry, in Bioprocessing for Biomolecules Production, 2019. Crossref
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Beg Sarwar, Alam Mohammad Naushad, Ahmad Farhan Jalees, Singh Bhupinder, Chylomicron mimicking nanocolloidal carriers of rosuvastatin calcium for lymphatic drug targeting and management of hyperlipidemia, Colloids and Surfaces B: Biointerfaces, 177, 2019. Crossref
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Vasconcelos Teófilo, Araújo Francisca, Lopes Carlos, Loureiro Ana, das Neves José, Marques Sara, Sarmento Bruno, Multicomponent self nano emulsifying delivery systems of resveratrol with enhanced pharmacokinetics profile, European Journal of Pharmaceutical Sciences, 137, 2019. Crossref
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van Staden Daniélle, du Plessis Jeanetta, Viljoen Joe, Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine, Pharmaceutics, 12, 6, 2020. Crossref
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Arun Jagdish Kumar, Vodeti Rajeshwar, Shrivastava Birendra, Bakshi Vasudha, Integrated Quality by Design Approach for Developing Nanolipidic Drug Delivery Systems of Olmesartan Medoxomil with Enhanced Antihypertensive Action, Advanced Pharmaceutical Bulletin, 10, 3, 2020. Crossref
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Kargozar Saeid, Baino Francesco, Hamzehlou Sepideh, Hamblin Michael R., Mozafari Masoud, Nanotechnology for angiogenesis: opportunities and challenges, Chemical Society Reviews, 49, 14, 2020. Crossref
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Bhura Mo. Rahil G., Shahiwala Aliasgar, Poorly Water-Soluble Drugs and Formulation Strategy to Improve Oral Bioavailability, in Novel Drug Delivery Technologies, 2019. Crossref
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Garnero Claudia, Aiassa Virginia, Longhi Marcela R., Innovative technological systems to optimize the delivery and therapeutic activity of antimicrobial drugs, in Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents, 2020. Crossref
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Bertoni Serena, Passerini Nadia, Albertini Beatrice, Nanomaterials for oral drug administration, in Nanotechnology for Oral Drug Delivery, 2020. Crossref
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Alfei Silvana, Nanotechnology Applications to Improve Solubility of Bioactive Constituents of Foods for Health-Promoting Purposes, in Nano-food Engineering, 2020. Crossref
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Yadav Vaishali, Jain Ashutosh Pal, Sharma Rajeev, Yadav Awesh K., Nanocarriers(s) Based Approaches in Cancer Therapeutics, Current Nanomedicine, 10, 2, 2020. Crossref
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Shi Zonghua, Alrobaian Majed, Kazmi Imran, Afzal Obaid, Altamimi Abdulmalik Saleh Alfawaz, Al-Abbasi Fahad A., Almalki Waleed H., Baothman Abdullah A., Choudhry Hani, Rahman Mahfoozur, Webster Thomas J., Beg Sarwar, Cationic self-nanoemulsifying formulations of tamoxifen with improved biopharmaceutical attributes and anticancer activity: Systematic development and evaluation, Journal of Molecular Liquids, 320, 2020. Crossref
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Liao Yuyao, Li Zhixun, Zhou Qing, Sheng Mengke, Qu Qingsong, Shi Yanshuang, Yang Jiaqi, Lv Lijing, Dai Xingxing, Shi Xinyuan, Saponin surfactants used in drug delivery systems: A new application for natural medicine components, International Journal of Pharmaceutics, 603, 2021. Crossref
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Kang Ji-Hyun, Yoo Kwang-Hwi, Park Hyo-Young, Hyun Seung-Min, Han Sang-Duk, Kim Dong-Wook, Park Chun-Woong, Preparation and In Vivo Evaluation of a Lidocaine Self-Nanoemulsifying Ointment with Glycerol Monostearate for Local Delivery, Pharmaceutics, 13, 9, 2021. Crossref
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Sailor Girish U., Self-Nanoemulsifying Drug Delivery Systems (SNEDDS): An Innovative Approach to Improve Oral Bioavailability, in Nanocarriers: Drug Delivery System, 2021. Crossref
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Zhu Yujin, Ye Jing, Zhang Quan, Self-emulsifying Drug Delivery System Improve Oral Bioavailability: Role of Excipients and Physico-chemical Characterization, Pharmaceutical Nanotechnology, 8, 4, 2020. Crossref
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Abou Assi Reem, Abdulbaqi Ibrahim M., Siok Yee Chan, The Evaluation of Drug Delivery Nanocarrier Development and Pharmacological Briefing for Metabolic-Associated Fatty Liver Disease (MAFLD): An Update, Pharmaceuticals, 14, 3, 2021. Crossref
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Liang Xi, Hua Yabing, Liu Qian, Li Zhiguo, Yu Fanglin, Gao Jing, Zhang Hui, Zheng Aiping, Solid Self-Emulsifying Drug Delivery System (Solid SEDDS) for Testosterone Undecanoate: In Vitro and In Vivo Evaluation, Current Drug Delivery, 18, 5, 2021. Crossref
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Alfei Silvana, Schito Anna Maria, Zuccari Guendalina, Nanotechnological Manipulation of Nutraceuticals and Phytochemicals for Healthy Purposes: Established Advantages vs. Still Undefined Risks, Polymers, 13, 14, 2021. Crossref
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de Oliveira Mariana Carla, Bruschi Marcos Luciano, Self-Emulsifying Systems for Delivery of Bioactive Compounds from Natural Origin, AAPS PharmSciTech, 23, 5, 2022. Crossref
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Dhaval Mori, Vaghela Poonam, Patel Kajal, Sojitra Keshvi, Patel Mohini, Patel Sushma, Dudhat Kiran, Shah Sunny, Manek Ravi, Parmar Ramesh, Lipid-based emulsion drug delivery systems — a comprehensive review, Drug Delivery and Translational Research, 12, 7, 2022. Crossref
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Le Nguyet-Minh Nguyen, Steinbring Christian, Le-Vinh Bao, Jalil Aamir, Matuszczak Barbara, Bernkop-Schnürch Andreas, Polyphosphate coatings: A promising strategy to overcome the polycation dilemma, Journal of Colloid and Interface Science, 587, 2021. Crossref
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Seo Eun Bin, du Plessis Lissinda H., Viljoen Joe M., Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria, Pharmaceuticals, 15, 2, 2022. Crossref
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Sinka Dávid, Doma Enikő, Szendi Nóra, Páll Jázmin, Kósa Dóra, Pető Ágota, Fehér Pálma, Ujhelyi Zoltán, Fenyvesi Ferenc, Váradi Judit, Vecsernyés Miklós, Szűcs Zsolt, Gonda Sándor, Cziáky Zoltán, Kiss-Szikszai Attila, Vasas Gábor, Bácskay Ildikó, Formulation, Characterization and Permeability Studies of Fenugreek (Trigonella foenum-graecum) Containing Self-Emulsifying Drug Delivery System (SEDDS), Molecules, 27, 9, 2022. Crossref
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Beg Sarwar, Kaur Ravinder, Khurana Rajneet Kaur, Rana Vikas, Sharma Teenu, Singh Bhupinder, QbD-Based Development of Cationic Self-nanoemulsifying Drug Delivery Systems of Paclitaxel with Improved Biopharmaceutical Attributes, AAPS PharmSciTech, 20, 3, 2019. Crossref
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Dhaval Mori, Sharma Shweta, Dudhat Kiran, Chavda Jayant, Twin-Screw Extruder in Pharmaceutical Industry: History, Working Principle, Applications, and Marketed Products: an In-depth Review, Journal of Pharmaceutical Innovation, 17, 2, 2022. Crossref
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Salawi Ahmad, Self-emulsifying drug delivery systems: a novel approach to deliver drugs, Drug Delivery, 29, 1, 2022. Crossref
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Singh Bhupinder, Sharma Teenu, Kaur Ranjot, Saini Sumant, Kaur Ripandeep, Beg Sarwar, QbD-Steered Systematic Development of Drug Delivery Nanoconstructs: Vital Precepts, Retrospect and Prospects, in Biomedical Translational Research, 2022. Crossref
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Wang Liying, Wang Xiangbo, Shen Lina, Alrobaian Majed, Panda Sunil K., Almasmoum Hussain A., Ghaith Mazen M., Almaimani Riyad A., Ibrahim Ibrahim Abdel Aziz, Singh Tanuja, Baothman Abdullah A., Choudhry Hani, Beg Sarwar, Paclitaxel and naringenin-loaded solid lipid nanoparticles surface modified with cyclic peptides with improved tumor targeting ability in glioblastoma multiforme, Biomedicine & Pharmacotherapy, 138, 2021. Crossref
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Miyake Miyuki, Kakizawa Yasushi, Tobori Norio, Kurioka Masatoshi, Tabuchi Nobuhito, Kon Ryo, Shimokawa Naofumi, Tsujino Yoshio, Takagi Masahiro, Membrane permeation of giant unilamellar vesicles and corneal epithelial cells with lipophilic vitamin nanoemulsions, Colloids and Surfaces B: Biointerfaces, 169, 2018. Crossref
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Kadian Renu, Nanda Arun, A Comprehensive Insight on Self Emulsifying Drug Delivery Systems, Recent Advances in Drug Delivery and Formulation, 16, 1, 2022. Crossref
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Usmani Afreen, Mishra Anuradha, Arshad Md, Jafri Asif, Development and evaluation of doxorubicin self nanoemulsifying drug delivery system with Nigella Sativa oil against human hepatocellular carcinoma, Artificial Cells, Nanomedicine, and Biotechnology, 47, 1, 2019. Crossref
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Earle R.R., Gadela V.R., Optimization and characterization of self-nanoemulsifying drug delivery system of iloperidone using box-behnken design and desirability function, Annales Pharmaceutiques Françaises, 2022. Crossref