Publicado 6 números por año
ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X
Indexed in
Pharmaceutical Cocrystals: A Novel Approach for Oral Bioavailability Enhancement of Drugs
SINOPSIS
Solid dosage forms are by far the preferred drug delivery systems. However, these often face the problem of poor and erratic bioavailability during the drug development process. Numerous formulation strategies for drug delivery are currently under development, among which the solid forms such as polymorphs, solvates, salts, and cocrystals have been considered to be the most important for improving dissolution rate and bioavailability. Cocrystallization is a fairly new approach in pharmaceutical industry that can improve the solubility and, consequently, the bioactivity of the active pharmaceutical ingredient (API) without compromising its structural integrity. Pharmaceutical cocrystals have found their place in drug delivery, primarily due to their ability to produce alternative, viable solid forms when a more standard approach of salt and polymorph formation fails to deliver the desired objectives. Over the past few years, a number of papers have been published focusing on a broad range of subjects, from traditional crystal engineering to structure-property relationships of cocrystals. The present review, however, illustrates how the cocrystalline forms of APIs have improved their in vitro dissolution rate and in vivo bioavailability, often correlating well with their improved solubility as well.
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Lin Hong-Liang, Zhang Gang-Chun, Hsu Po-Chun, Lin Shan-Yang, A portable fiber-optic Raman analyzer for fast real-time screening and identifying cocrystal formation of drug-coformer via grinding process, Microchemical Journal, 110, 2013. Crossref
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Shete Amol S, Yadav Adhikrao V, Murthy Srinivasa M, Chitosan and chitosan chlorhydrate based various approaches for enhancement of dissolution rate of carvedilol, DARU Journal of Pharmaceutical Sciences, 20, 1, 2012. Crossref
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Lin Hong-Liang, Zhang Gang-Chun, Huang Yu-Ting, Lin Shan-Yang, An Investigation of Indomethacin–Nicotinamide Cocrystal Formation Induced by Thermal Stress in the Solid or Liquid State, Journal of Pharmaceutical Sciences, 103, 8, 2014. Crossref
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Mohd Abdul Bari, Sanka Krishna, Bandi Srikanth, Diwan Prakash V., Shastri Nalini, Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and antidiabetic activity in albino rabbits, Drug Delivery, 22, 4, 2015. Crossref
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Lin Hong-Liang, Zhang Gang-Chun, Lin Shan-Yang, Real-time co-crystal screening and formation between indomethacin and saccharin via DSC analytical technique or DSC–FTIR microspectroscopy, Journal of Thermal Analysis and Calorimetry, 120, 1, 2015. Crossref
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Arkhipov S. G., Boldyreva E. V., An algorithm to identify the existence and reproducibly obtain single crystals of salts and mixed crystals of amino acids suitable for single crystal XRD and Raman spectroscopy experiments, Journal of Structural Chemistry, 55, 4, 2014. Crossref
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Fischer Franziska, Scholz Gudrun, Batzdorf Lisa, Wilke Manuel, Emmerling Franziska, Synthesis, structure determination, and formation of a theobromine : oxalic acid 2 : 1 cocrystal, CrystEngComm, 17, 4, 2015. Crossref
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Serrano Dolores R, O'Connell Peter, Paluch Krzysztof J, Walsh David, Healy Anne Marie, Cocrystal habit engineering to improve drug dissolution and alter derived powder properties, Journal of Pharmacy and Pharmacology, 68, 5, 2016. Crossref
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Lin Hong-Liang, Huang Yu-Ting, Lin Shan-Yang, Spectroscopic and thermal approaches to investigate the formation mechanism of piroxicam–saccharin co-crystal induced by liquid-assisted grinding or thermal stress, Journal of Thermal Analysis and Calorimetry, 123, 3, 2016. Crossref
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London Bianca King, Claville Michelle O. Fletcher, Babu Sainath, Fronczek Frank R., Uppu Rao M., A co-crystal of nonahydrated disodium(II) with mixed anions fromm-chlorobenzoic acid and furosemide, Acta Crystallographica Section E Crystallographic Communications, 71, 10, 2015. Crossref
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Lin Shan-Yang, Lin Hong-Liang, Chi Ying-Ting, Hung Ru-Ying, Huang Yu-Ting, Hsieh Wei-Hsien, Kao Chi-Yu, Influence of Soluplus on Solid-State Properties and Physical Stability of Indomethacin-Saccharin Co-crystal Formation Prepared by Air-Drying Process, Journal of Pharmaceutical Innovation, 11, 2, 2016. Crossref
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Serrano Dolores.R., Persoons Tim, D'Arcy Deirdre M., Galiana Carolina, Dea-Ayuela Maria Auxiliadora, Healy Anne Marie, Modelling and shadowgraph imaging of cocrystal dissolution and assessment of in vitro antimicrobial activity for sulfadimidine/4-aminosalicylic acid cocrystals, European Journal of Pharmaceutical Sciences, 89, 2016. Crossref
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Li Jianhui, Wang Lianyan, Ye Yue Qi, Fu Xue, Ren Qinghua, Zhang Hailu, Deng Zongwu, Improving the solubility of dexlansoprazole by cocrystallization with isonicotinamide, European Journal of Pharmaceutical Sciences, 85, 2016. Crossref
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Huang Zun, Xia Jing, Li Jing, Gao Xuan, Wang Yiyue, Shen Qi, Optimization and bioavailability evaluation of self-microemulsifying drug delivery system of the daidzein–nicotinamide complex, RSC Advances, 6, 113, 2016. Crossref
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Lin Shan-Yang, Simultaneous screening and detection of pharmaceutical co-crystals by the one-step DSC–FTIR microspectroscopic technique, Drug Discovery Today, 22, 4, 2017. Crossref
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Desai Preshita P., Patravale Vandana B., Curcumin Cocrystal Micelles—Multifunctional Nanocomposites for Management of Neurodegenerative Ailments, Journal of Pharmaceutical Sciences, 107, 4, 2018. Crossref
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Cysewski Piotr, In silico screening of dicarboxylic acids for cocrystallization with phenylpiperazine derivatives based on both cocrystallization propensity and solubility advantage, Journal of Molecular Modeling, 23, 4, 2017. Crossref
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Nechipadappu Sunil Kumar, Ramachandran Jeeshma, Shivalingegowda Naveen, Lokanath Neratur Krishnappagowda, Trivedi Darshak R., Synthesis of cocrystals/salts of flucytosine: Structure and stability, New Journal of Chemistry, 42, 7, 2018. Crossref
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Barmpalexis Panagiotis, Karagianni Anna, Katopodis Konstantinos, Vardaka Elisavet, Kachrimanis Kyriakos, Molecular modelling and simulation of fusion-based amorphous drug dispersions in polymer/plasticizer blends, European Journal of Pharmaceutical Sciences, 130, 2019. Crossref
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Rathi Noopur, Paradkar Anant, Gaikar Vilas G., Polymorphs of Curcumin and Its Cocrystals With Cinnamic Acid, Journal of Pharmaceutical Sciences, 108, 8, 2019. Crossref
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Xu Yingxin, Fang Tianxu, Yang Yifan, Sun Li’ang, Shen Qi, Preparation of Deoxycholate-Modified Docetaxel-Cimetidine Complex Chitosan Nanoparticles to Improve Oral Bioavailability, AAPS PharmSciTech, 20, 7, 2019. Crossref
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Budziak , Arczewska , Kamiński , Formation of Prenylated Chalcone Xanthohumol Cocrystals: Single Crystal X-Ray Diffraction, Vibrational Spectroscopic Study Coupled with Multivariate Analysis, Molecules, 24, 23, 2019. Crossref
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Agafonov Mikhail, Volkova Tatyana, Kumeev Roman, Delyagina Ekaterina, Terekhova Irina, Experimental study on interactions occurring between Pluronics and leflunomide in solution, Journal of Molecular Liquids, 302, 2020. Crossref
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Volkova Tatyana V., Perlovich German L., Comparative analysis of solubilization and complexation characteristics for new antifungal compound with cyclodextrins. Impact of cyclodextrins on distribution process, European Journal of Pharmaceutical Sciences, 154, 2020. Crossref
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Adebayo J. O., Tijjani H., Adegunloye A. P., Ishola A. A., Balogun E. A., Malomo S. O., Enhancing the antimalarial activity of artesunate, Parasitology Research, 119, 9, 2020. Crossref
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Terekhov Roman P., Selivanova Irina A., Tyukavkina Nonna A., Ilyasov Igor R., Zhevlakova Anastasiya K., Dzuban Alexander V., Bogdanov Anatoliy G., Davidovich Georgiy N., Shylov Gennadii V., Utenishev Andrey N., Kovalev Dmitriy Yu., Fenin Anatoliy A., Kabluchko Tatyana G., Assembling the Puzzle of Taxifolin Polymorphism, Molecules, 25, 22, 2020. Crossref
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Liu Yanjie, Zhao Xiuhua, Zhang Qian, Wang Lingling, Li Yuanyuan, Li Yuanzuo, Characterization and Evaluation of the Solubility and Oral Bioavailability of Rutin–Ethanolate Solvate, AAPS PharmSciTech, 21, 7, 2020. Crossref
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Chadha Renu, Saini Anupam, Jain Dharamvir S., Venugopalan P., Preparation and Solid-State Characterization of Three Novel Multicomponent Solid Forms of Oxcarbazepine: Improvement in Solubility through Saccharin Cocrystal, Crystal Growth & Design, 12, 8, 2012. Crossref
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Stewart Aaron M., Grass Michael E., Mudie Deanna M., Morgen Michael M., Friesen Dwayne T., Vodak David T., Development of a Biorelevant, Material-Sparing Membrane Flux Test for Rapid Screening of Bioavailability-Enhancing Drug Product Formulations, Molecular Pharmaceutics, 14, 6, 2017. Crossref
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Lewandowska Urszula, Szewczyk Karolina, Hrabec Elżbieta, Janecka Anna, Gorlach Sylwia, Overview of Metabolism and Bioavailability Enhancement of Polyphenols, Journal of Agricultural and Food Chemistry, 61, 50, 2013. Crossref
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Kariuki Benson M., Abdel-Wahab Bakr F., Bekheit Mohamed S., El-Hiti Gamal A., Intermolecular Interactions of 3,5-bis(4-Methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide in a Cocrystal with 1,3-bis(4-Methoxyphenyl)prop-2-en-1-one and Dimethylformamide Solvate, Crystals, 12, 5, 2022. Crossref
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Bolla Geetha, Sarma Bipul, Nangia Ashwini K., Crystal Engineering of Pharmaceutical Cocrystals in the Discovery and Development of Improved Drugs, Chemical Reviews, 122, 13, 2022. Crossref
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Wang Zhipeng, Xie Yifei, Yu Mingchao, Yang Shiying, Lu Yang, Du Guanhua, Recent Advances on the Biological Study of Pharmaceutical Cocrystals, AAPS PharmSciTech, 23, 8, 2022. Crossref