Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Therapeutic Drug Carrier Systems
Factor de Impacto: 2.9 Factor de Impacto de 5 años: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X

Volumes:
Volumen 37, 2020 Volumen 36, 2019 Volumen 35, 2018 Volumen 34, 2017 Volumen 33, 2016 Volumen 32, 2015 Volumen 31, 2014 Volumen 30, 2013 Volumen 29, 2012 Volumen 28, 2011 Volumen 27, 2010 Volumen 26, 2009 Volumen 25, 2008 Volumen 24, 2007 Volumen 23, 2006 Volumen 22, 2005 Volumen 21, 2004 Volumen 20, 2003 Volumen 19, 2002 Volumen 18, 2001 Volumen 17, 2000 Volumen 16, 1999 Volumen 15, 1998 Volumen 14, 1997 Volumen 13, 1996 Volumen 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v22.i4.10
pages 331-418

Modification of Epithelial Tight Junction Integrity to Enhance Transmucosal Absorption

Randall J. Mrsny
School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, Wales, UK CF10 3XF

SINOPSIS

Tight junctions (TJs) located between adjacent epithelial cells restrict the movement of solutes, ions, and even water. Restriction of macromolecules by TJ structures impedes one potential route of absorption for biopharmaceutical drugs, a route known as the paracellular pathway. It is anticipated that an improved understanding of TJ structure and cellular mechanisms that regulate its function will lead to successful strategies for improved transmucosal drug absorption through the paracellular pathway. Based upon clinical correlations between TJ dysfunction and several disease states, any approach to modify TJ integrity to enhance drug absorption in this way must be tempered by an appreciation of potential safety concerns that might develop through sustained or repeated TJ alterations. This review describes a current understanding of epithelial TJ organization and examines potential methods and implications for regulated modification of TJ function for the enhanced uptake of drugs without detrimental clinical outcomes.


Articles with similar content:

Interactions of Migrating T Lymphocytes, Inflammatory Mediators, and the Extracellular Matrix
Critical Reviews™ in Immunology, Vol.15, 1995, issue 3-4
Rami Hershkoviz, Sylvia G. Kachalsky, Ofer Lider
Polymeric Nanoparticles for Oral Delivery of Drugs and Vaccines: A Critical Evaluation of In Vivo Studies
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.22, 2005, issue 5
Eric Doelker, Eric Allemann, Sergio A. Galindo-Rodriguez, Hatem Fessi
Antigen-Specific B-Lymphocyte Activation
Critical Reviews™ in Immunology, Vol.23, 2003, issue 3
Gail A. Bishop, Sokol A. Haxhinasto, Bruce S. Hostager, Laura L. Stunz
Biomechanical Basis of Vascular Tissue Engineering
Critical Reviews™ in Biomedical Engineering, Vol.27, 1999, issue 1-2
S. Q. Liu
Oral Absorption Promoters: Opportunities, Issues, and Challenges
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.32, 2015, issue 5
Sushilkumar Patil, Girish Kore, Atul Kolate, Chetan Yewale, Ambikanandan Misra