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Critical Reviews™ in Therapeutic Drug Carrier Systems

Publicado 6 números por año

ISSN Imprimir: 0743-4863

ISSN En Línea: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Clinical Success versus Attrition of Investigational Pharmaceuticals: A Vignette

Volumen 34, Edición 6, 2017, pp. 527-549
DOI: 10.1615/CritRevTherDrugCarrierSyst.2017018747
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SINOPSIS

The clinical success of investigational pharmaceuticals remains doubtful due to an unacceptable level of attrition during clinical drug development and declining clinical approval rates. Countless molecules are being withdrawn during drug discovery and clinical trial phases due to poor pharmacokinetics (ADME), lack of safety and efficacy, commercial interests, market competition, and patent protection expiry. Consequently, the novel drug pipelines are running dry. Because huge capital is involved in different clinical trial phases, the task of bringing a new drug or drug formulation to the market is a very costly venture. Running a clinical trial is a complex, expensive, and time-intensive project. It is often tedious and troublesome to change a study design after its inception; thus, it is necessary to design the study for easy and comprehensive data analysis and interpretation. Cohort, cross-sectional, and case-control studies, collectively touted as observational studies, provide an option for solving clinical problems when a randomized controlled trial (RCT) is not feasible due to time, money, or ethical restraints. This review article presents three prime observational research methodologies using relevant examples, common causes of spurious results, and ways to trivialize their impacts, including the most popular indices for measuring clinical relevance of the treatment effects. The article also explores attrition issues and issues related to the improvement of clinical approval success, with an emphasis on possible applications of drug delivery technologies to salvage drug molecules.

CITADO POR
  1. Swaminathan Soumya, Kumar Vijay, Kaul Rajni, Need for alternatives to animals in experimentation: An Indian perspective, Indian Journal of Medical Research, 149, 5, 2019. Crossref

  2. Dawson John C., Carragher Neil O., Elucidating Target Biology and Drug Mechanism of Action Across Human Cell‐Based Model Systems, in Target Discovery and Validation, 2019. Crossref

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