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Critical Reviews™ in Therapeutic Drug Carrier Systems

Publicado 6 números por año

ISSN Imprimir: 0743-4863

ISSN En Línea: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Implication of Formulation Strategies on the Bioavailability of Selected Plant-Derived Hepatoprotectants

Volumen 34, Edición 6, 2017, pp. 489-526
DOI: 10.1615/CritRevTherDrugCarrierSyst.2017019623
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SINOPSIS

Plant-derived active ingredients with hepatoprotective activity have been used extensively in the treatment of various liver diseases. These compounds are used either in their natural form or the chemical constituents present therein serve as templates for the development of synthetic-based therapeutic entities. Current research interests are focused on formulation development and pharmacokinetic studies of herbal medicines. This article provides a comprehensive review on formulation influences on the preclinical/clinical pharmacokinetics of selected hepatoprotectants such as silymarin, curcumin, glycyrrhizin, andrographolide, phyllanthin, hypophyllanthin, and picroside I and II. Both the formulation and pharmacokinetic factors could affect the target-site concentrations of the active herbal components and, thus, the therapeutic responses. This review contributes to the establishment of a comprehensive understanding of the influence of formulation/dosage form on the pharmacokinetic profile of the hepatoprotective compounds.

CITADO POR
  1. Tvrdý Václav, Pourová Jana, Jirkovský Eduard, Křen Vladimír, Valentová Kateřina, Mladěnka Přemysl, Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin, Medicinal Research Reviews, 41, 4, 2021. Crossref

  2. Shams Ammara , Brice Landry Koloko , Shams Faiza , Tariq Somayya , Azeem Ayesha , Anjum Hamza , Latief Noreen , Malik Kausar , Ijaz Bushra, Hepatoprotective and Anti-inflammatory Potential of Crude methanolic extract of Euphorbia pilulifera via NF-KB/Nrf2/Akt/TGF-β1 pathway, Pakistan BioMedical Journal, 2022. Crossref

  3. Jang Eungyeong, Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases, Antioxidants, 11, 8, 2022. Crossref

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