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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Imprimir: 0893-9675
ISSN En Línea: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v12.i1-2.70
pages 127-150

siRNA: A Potential Tool for Future Breast Cancer Therapy?

Gro Leite Storvold
Institute of Medical Genetics, University of Oslo, N-0315 Oslo, Norway; and University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599
Tone Ikdahl Andersen
Department of Oncology, Ullevel University Hospital, N-0407 Oslo, Norway
Charles M. Perou
University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599
Eirik Frengen
Institute of Medical Genetics, University of Oslo, and Department of Medical Genetics, Ullevel University Hospital, Oslo, Norway; and University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599

SINOPSIS

The siRNA technology is a promising research tool for use in functional genomics, and it also shows potential for use in future therapy. Thus far, siRNAs have been used to specifically silence disease-associated alleles in animal models. The technology is still quite new, and the biological mechanisms underlying RNAi and siRNA-mediated knockdown of gene expression are not yet fully understood. The main issues when siRNAs are designed are efficiency and specificity, and it is of great importance to consider possible off-target effects in the siRNA design. One major challenge in siRNA-based therapy is the development of systems for efficient delivery to the target cells. A large number of tools have, over the last few years, been designed for the delivery of DNA and RNA for gene therapy, and extensive efforts are now placed into developing clinical applications of siRNAs in a range of human diseases, including breast cancer.


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