Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Imprimir: 0893-9675
ISSN En Línea: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v18.i1-2.80
pages 135-151

Tumor-Stromal Interactions in Pancreatic Cancer

Clifford Whatcott
Clinical Translational Research Division, The Translational Genomics Research Institute (TGEN), Phoenix, Arizona
Haiyong Han
Clinical Translational Research Division, The Translational Genomics Research Institute (TGEN), Phoenix, Arizona
Richard G. Posner
Clinical Translational Research Division, The Translational Genomics Research Institute (TGEN), Phoenix, Arizona
Daniel D. Von Hoff
Clinical Translational Research Division, The Translational Genomics Research Institute (TGEN), Phoenix, Arizona

SINOPSIS

The tumor associated stroma has been described in recent years as being complicit in tumor growth in pancreatic cancer. The stroma hosts a variety of components of both cellular and molecular makeup. In normal tissues, the stroma provides nutrients and regulatory signals for proper cellular polarity and function. However, following oncogenic transformation, the stromal compartment is conscripted to provide stimulatory signals and protection to tumor cells. It is these tumor-stromal interactions that are currently of great therapeutic interest. Several key reports have suggested that therapeutic targeting of the tumor-stromal interactions in pancreatic cancer has the potential to offer survival benefit. In this review, we will discuss the tumor-stromal interactions that contribute to tumor growth and progression, and ways in which we might counter these interactions.


Articles with similar content:

Role of Immune-Cell−Expressing Kruppel-Like Factor 4 in Cancer Development
Forum on Immunopathological Diseases and Therapeutics, Vol.7, 2016, issue 1-2
Walden Ai
Recent Advances in Cancer Stem Cell Targeted Therapy
Critical Reviews™ in Oncogenesis, Vol.24, 2019, issue 1
Muge Ocal, Hakan Akbulut, Samira Abdi Abgarmi, Merve Besler, Cansu Babahan
Emerging Receptor Tyrosine Kinase Drug Targets: Implications for Antibody-Based Therapies for Oncology and Immunologic Disorders
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 5-6
Diego Alvarado, Andrew J. Garton, Theresa M. LaVallee, Gerald McMahon, E. Sergio Trombetta, Richard Gedrich
MicroRNAs: Cobblestones on the Road to Cancer Metastasis
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 4
Valentina Profumo, Paolo Gandellini
Physiological, Tumor, and Metastatic Niches: Opportunities and Challenges for Targeting the Tumor Microenvironment
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 3-4
Meera Murgai, Rosandra Kaplan, Amber Giles