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Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

The CD44 Adhesion Molecule and Metastasis

Volumen 5, Edición 2-3, 1994, pp. 201-212
DOI: 10.1615/CritRevOncog.v5.i2-3.50
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SINOPSIS

The family of related cell surface adhesion molecules designated CD44 are multifunctional proteins displayed by a wide variety of normal and malignant tissues. CD44 properties in vitro include hyaluronate-mediated adhesion, motility, hyaluronate degradation, self-aggregation, and adhesion to lymphoid tissue. These properties are among several that are required by invasive and metastatic tumor cells. Several in vivo experiments indicate that tumor cells transfected to overexpress specific CD44 isoforms display an enhancement in metastatic potential. Numerous CD44 isoforms exist as a result of alternative splicing, and specific isoforms enhance tumor cell metastasis more efficiently than others. This suggests that regulation of CD44 alternative splicing is an important determinant of metastatic potential. Several human tumors display specific alterations in CD44 isoform expression, and the extent of clinical disease in specific tumors correlates with the CD44 isoform expression pattern. In this review we analyze these data that suggest that CD44 plays an important role in tumor metastasis.

CITADO POR
  1. Uhl-Steidl , Huy , Muller-Holzner , Ruth , Zeimet , Stauder , Daxenbichler , Marth , CD44 splice variant expression in normal and malignant uterine cervical epithelium, International Journal of Gynecological Cancer, 8, 6, 1998. Crossref

  2. RADOTRA B., MCCORMICK D., GLIOMA INVASIONIN VITRO IS MEDIATED BY CD44-HYALURONAN INTERACTIONS, The Journal of Pathology, 181, 4, 1997. Crossref

  3. Komminoth P., Seelentag W. K. F., Saremaslani P., Heitz Ph. U., Roth J., CD44 isoform expression in the diffuse neuroendocrine system. II. Benign and malignant tumors, Histochemistry and Cell Biology, 106, 6, 1996. Crossref

  4. Oliveira D. T., Sherriff M., Odell E. W., Expression of CD44 variant exons by primary and metastatic oral squamous carcinomas, Journal of Oral Pathology & Medicine, 27, 7, 2007. Crossref

  5. Yip Stephen, Aboody Karen S., Burns Michael, Imitola Jaime, Boockvar John A., Allport Jennifer, Park Kook In, Teng Yang D., Lachyankar Mahesh, McIntosh Tracy, OʼRourke Donald M., Khoury Samia, Weissleder Ralph, Black Peter M., Weiss William, Snyder Evan Y., Neural Stem Cell Biology May Be Well Suited for Improving Brain Tumor Therapies, The Cancer Journal, 9, 3, 2003. Crossref

  6. HEROLD-MENDE CHRISTEL, SEITER SIMONE, BORN ANTONIO I., PATZELT ERIK, SCHUPP MICHAEL, ZÖLLER JOACHIM, BOSCH FRANZ X., ZÖLLER MARGOT, EXPRESSION OF CD44 SPLICE VARIANTS IN SQUAMOUS EPITHELIA AND SQUAMOUS CELL CARCINOMAS OF THE HEAD AND NECK, The Journal of Pathology, 179, 1, 1996. Crossref

  7. Gu Jing, Daa Tsutomu, Kashima Kenji, Yokoyama Shigeo, Nakayama Iwao, Noguchi Shiro, Expression of splice variants of CD44 in thyroid neoplasms derived from follicular cells, Pathology International, 48, 3, 1998. Crossref

  8. Ramakrishna Suresh, Suresh Bharathi, Baek Kwang-Hyun, Biological functions of hyaluronan and cytokine-inducible deubiquitinating enzymes, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1855, 1, 2015. Crossref

  9. El-Hariry Iman, Pignatelli Massimo, Adhesion molecules: opportunities for modulation and a paradigm for novel therapeutic approaches in cancer, Expert Opinion on Investigational Drugs, 6, 10, 1997. Crossref

  10. Khaldoyanidi Sophia, Achtnich Martin, Hehlmann Rüdiger, Zöller Margot, Expression of CD44 variant isoforms in peripheral blood leukocytes in malignant lymphoma and leukemia: Inverse correlation between expression and tumor progression, Leukemia Research, 20, 10, 1996. Crossref

  11. Hiscox S., Jiang W.G., Regulation of Endothelial CD44 Expression and Endothelium–Tumour Cell Interactions by Hepatocyte Growth Factor/Scatter Factor, Biochemical and Biophysical Research Communications, 233, 1, 1997. Crossref

  12. Chiu Roland K., Droll Armin, Dougherty Shona T., Carpenito Carmine, Cooper David L., Dougherty Graeme J., Alternatively Spliced CD44 Isoforms Containing Exon v10 Promote Cellular Adhesion through the Recognition of Chondroitin Sulfate-Modified CD44, Experimental Cell Research, 248, 1, 1999. Crossref

  13. Milon Geneviève, Cossart Pascale, Live recombinant Listeria monocytogenes as an immunotherapeutic agent for experimental tumors, Trends in Microbiology, 3, 12, 1995. Crossref

  14. Lam Alfred King Y., Molecular biology of esophageal squamous cell carcinoma, Critical Reviews in Oncology/Hematology, 33, 2, 2000. Crossref

  15. Tjhay Francisca, Motohara Takeshi, Tayama Shingo, Narantuya Dashdemberel, Fujimoto Koichi, Guo Jianying, Sakaguchi Isao, Honda Ritsuo, Tashiro Hironori, Katabuchi Hidetaka, CD 44 variant 6 is correlated with peritoneal dissemination and poor prognosis in patients with advanced epithelial ovarian cancer , Cancer Science, 106, 10, 2015. Crossref

  16. Ayhan Ayşe, Baykal Cem, Al Atakan, Ayhan Ali, Altered CD44 Variant 6 Expression in FIGO Stage IB Cervical Carcinoma, Gynecologic Oncology, 83, 3, 2001. Crossref

  17. Saxon Benjamin R., Byard Roger W., Han Ping, Cellular Expression of Adhesion Factors in Childhood Rhabdomyosarcoma, Pediatric Pathology & Laboratory Medicine, 17, 2, 1997. Crossref

  18. Hill Prudence A., Lan Hui Y., Atkins Robert C., Nikolic-Paterson David J., Ultrastructural localisation of CD44 in the rat lung in experimental Goodpasture’s syndrome, Pathology, 29, 4, 1997. Crossref

  19. Zhang Qiu-Shuang, Heng Yang, Yuan Yu-He, Chen Nai-Hong, Pathological α-synuclein exacerbates the progression of Parkinson’s disease through microglial activation, Toxicology Letters, 265, 2017. Crossref

  20. Tan B, Wang J H, Wu Q D, Kirwan W O, Redmond H P, Sodium hyaluronate enhances colorectal tumour cell metastatic potential in vitro and in vivo , British Journal of Surgery, 88, 2, 2002. Crossref

  21. Thomas GJ, Speight P.M., Cell Adhesion Molecules and Oral Cancer, Critical Reviews in Oral Biology & Medicine, 12, 6, 2001. Crossref

  22. Li Xiaoran, Grigalavicius Mantas, Li Yaqing, Li Xiaoli, Zhong Yali, Huang Ruixia, Yu Dandan, Berge Viktor, Goscinski Mariusz Adam, Kvalheim Gunnar, Nesland Jahn M, Suo Zhenhe, MtDNA depletion influences the transition of CD44 subtypes in human prostate cancer DU145 cells, Tumor Biology, 39, 8, 2017. Crossref

  23. Crainie Mary, Belch Andrew R., Mant Michael J., Pilarski Linda M., Overexpression of the Receptor for Hyaluronan-Mediated Motility (RHAMM) Characterizes the Malignant Clone in Multiple Myeloma: Identification of Three Distinct RHAMM Variants, Blood, 93, 5, 1999. Crossref

  24. Crainie Mary, Belch Andrew R., Mant Michael J., Pilarski Linda M., Overexpression of the Receptor for Hyaluronan-Mediated Motility (RHAMM) Characterizes the Malignant Clone in Multiple Myeloma: Identification of Three Distinct RHAMM Variants, Blood, 93, 5, 1999. Crossref

  25. Moraes Karen C. M., RNA Surveillance: Molecular Approaches in Transcript Quality Control and their Implications in Clinical Diseases, Molecular Medicine, 16, 1-2, 2010. Crossref

  26. Hiscox Steve, Cancer and Cancer Metastasis-Related Genes, in Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention, 1, 2004. Crossref

  27. Günthert U., CD44 in Maligant Disorders, in Attempts to Understand Metastasis Formation I, 213/1, 1996. Crossref

  28. Benz Patrik S., Fan Xiaohong, Wüthrich Rudolf P., Enhanced tubular epithelial CD44 expression in MRL-lpr lupus nephritis, Kidney International, 50, 1, 1996. Crossref

  29. Cote Gilbert J., Huang Eileen S-C., Jin Wei, Morrison Richard S., Sequence Requirements for Regulated RNA Splicing of the Human Fibroblast Growth Factor Receptor-1 α Exon, Journal of Biological Chemistry, 272, 2, 1997. Crossref

  30. Lee Wang Hee, Rho Jun Gi, Han Hwa Seung, Kweon Sohui, Nguyen Van Quy, Park Jae Hyung, Kim Wook, Self-assembled hyaluronic acid nanoparticle suppresses fat accumulation via CD44 in diet-induced obese mice, Carbohydrate Polymers, 237, 2020. Crossref

  31. Schischmanoff P. Olivier, Yaswen Paul, Parra Marilyn K., Lee Gloria, Chasis Joel A., Mohandas Narla, Conboy John G., Cell Shape-dependent Regulation of Protein 4.1 Alternative Pre-mRNA Splicing in Mammary Epithelial Cells, Journal of Biological Chemistry, 272, 15, 1997. Crossref

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