Suscripción a Biblioteca: Guest
Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Kaposi's Sarcoma Pathogenesis: A Link between Immunology and Tumor Biology

Volumen 9, Edición 2, 1998, pp. 107-124
DOI: 10.1615/CritRevOncog.v9.i2.20
Get accessGet access

SINOPSIS

Kaposi's sarcoma (KS) was a rare disease in Europe and North America until a decade ago, when it became the most common neoplasm complicating the acquired immunodeficiency syndrome (AIDS), where it acquires an aggressive course. Clinical and experimental data suggest that, at least in early stage, KS may not be a true sarcoma, but an hyperplastic-proliferative lesion that may regress. At least three components characterize KS lesions: (1) neoangiogenesis and proliferation of spindle-shaped cells of endothelial and macrophage cell origin, some of which may originate from a circulating precursor; (2) a cellular infiltrate represented by macrophages, lymphoid cells, mast cells, and neutrophils; and (3) the infection of spindle cells and mononuclear cells with a new virus of the Herpesvirinae family defined KS-associated herpesvirus or human herpesvirus-8 (HHV-8). KS lesions are highly responsive, in terms of growth, to inflammatory cytokines (IC) and many lesional cell components are able to secrete cytokines and chemokines, which induce paracrine-autocrine mechanisms of growth, angiogenesis, and promote further cellular recruitment. The association between HHV-8 and KS is close; however, the role of the virus in KS development is yet unknown. Nevertheless, the virus has the potential to encode for homologs of cellular cytokines and some chemokines and its reactivation is sensitive to stimuli provided by IC. This review focuses on these aspects of KS pathogenesis, trying to reconcile many of the clinical and experimental observations. Finally, the role of the HIV-1 Tat protein as a factor of progression in AIDS-KS as well as the role of cellular and HHV-8 encoded proto-oncogenes as factors and markers of progression of KS to a true malignancy is reviewed.

CITADO POR
  1. Rice Jason, Lima Brigitte?de, Stevenson Freda?K., Stevenson Philip?G., A ?-herpesvirus immune evasion gene allows tumor cellsin vivo to escape attack by cytotoxic T cells specific for a tumor epitope, European Journal of Immunology, 32, 12, 2002. Crossref

  2. Cai Qiliang, Verma Suhbash C., Lu Jie, Robertson Erle S., , 78, 2010. Crossref

  3. Lapidot Aviva, Litovchick Alexander, Novel HIV Tat antagonists, Drug Development Research, 50, 3-4, 2000. Crossref

  4. Bussolati Benedetta, Grange Cristina, Bruno Stefania, Buttiglieri Stefano, Deregibus Maria Chiara, Tei Lorenzo, Aime Silvio, Camussi Giovanni, Neural-cell adhesion molecule (NCAM) expression by immature and tumor-derived endothelial cells favors cell organization into capillary-like structures, Experimental Cell Research, 312, 6, 2006. Crossref

  5. Brown Elizabeth E., Whitby Denise, Vitale Francesco, Marshall Vickie, Mbisa Georgina, Gamache Christine, Lauria Carmela, Alberg Anthony J., Serraino Diego, Cordiali-Fei Paola, Messina Angelo, Goedert James J., Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma, Cancer, 107, 9, 2006. Crossref

  6. Hengge U.R., Stocks K., Goos M., Acquired immune deficiency syndrome-related hyperkeratotic Kaposi’s sarcoma with severe lymphoedema: report of five cases, British Journal of Dermatology, 142, 3, 2000. Crossref

  7. Cherrington Julie M., Strawn Laurie M., Shawver Laura K., , 79, 2000. Crossref

  8. Sullivan Ryan, Dezube Bruce J, Koon Henry B, Signal transduction targets in Kaposi's sarcoma, Current Opinion in Oncology, 18, 5, 2006. Crossref

  9. Chen Yu, Zhao Liang, Qiu Shao-peng, He Xiao-shun, Kaposi Sarcoma of the Ureter After Liver Transplant: Case Report and Literature Review, Experimental and Clinical Transplantation, 10, 1, 2012. Crossref

  10. Mbulaiteye Sam M, Parkin D.Maxwell, Rabkin Charles S, Epidemiology of AIDS-related malignancies, Hematology/Oncology Clinics of North America, 17, 3, 2003. Crossref

  11. White Martyn K., Gorrill Timothy S., Khalili Kamel, Reciprocal transactivation between HIV-1 and other human viruses, Virology, 352, 1, 2006. Crossref

  12. Foreman Kimberly E, Friborg Jacques, Chandran Bala, Katano Harutaka, Sata Tetsutaro, Mercader Maria, Nabel Gary J, Nickoloff Brian J, Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions, Journal of Dermatological Science, 26, 3, 2001. Crossref

  13. Zhang Junjie, Zhu Lining, Lu Xiaolu, Feldman Emily R., Keyes Lisa R., Wang Yi, Fan Hui, Feng Hao, Xia Zanxian, Sun Jiya, Jiang Taijiao, Gao Shou-jiang, Tibbetts Scott A., Feng Pinghui, Hutt-Fletcher Lindsey, Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice, PLOS Pathogens, 11, 6, 2015. Crossref

  14. Wang Ena, Panelli Monica, Marincola Francesco M., Autologous Tumor Rejection in Humans: Trimming the Myths, Immunological Investigations, 35, 3-4, 2006. Crossref

  15. Yoo Jaehyuk, Kang Jinjoo, Lee Ha Neul, Aguilar Berenice, Kafka Darren, Lee Sunju, Choi Inho, Lee Juneyong, Ramu Swapnika, Haas Juergen, Koh Chester J., Hong Young-Kwon, Ganem Donald E., Kaposin-B Enhances the PROX1 mRNA Stability during Lymphatic Reprogramming of Vascular Endothelial Cells by Kaposi's Sarcoma Herpes Virus, PLoS Pathogens, 6, 8, 2010. Crossref

  16. Cheng Fang, Weidner-Glunde Magdalena, Varjosalo Markku, Rainio Eeva-Marja, Lehtonen Anne, Schulz Thomas F., Koskinen Päivi J., Taipale Jussi, Ojala Päivi M., Früh Klaus, KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA, PLoS Pathogens, 5, 3, 2009. Crossref

  17. Núñez Marina, Machuca Ana, Soriano Vincent, Podzamczer Daniel, González-Lahoz Juan, Clearance of human herpesvirus type 8 viraemia in HIV-1-positive patients with Kaposi's sarcoma treated with liposomal doxorubicin, AIDS, 14, 8, 2000. Crossref

  18. Klouche Mariam, Brockmeyer Norbert, Knabbe Cornelius, Rose-John Stefan, Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells, AIDS, 16, 8, 2002. Crossref

  19. Rusnati M., Taraboletti G., Urbinati C., Tulipano G., Giuliani R., Molinari-Tosatti M. P., Sennino B., Giacca M., Tyagi M., Albini A., Noonan D., Giavazzi R, Presta M., Thrombospondin‐1/HIV‐1 Tat protein interaction: modulation of the biological activity of extracellular Tat, The FASEB Journal, 14, 13, 2000. Crossref

  20. Demirovic A. Rubio, Canadi J., Weiglhofer W., Scheidegger P., Jaussi R., Ballmer-Hofer K., HIV TAT Basic Peptide Is Not a High-Affinity Ligand for VEGF Receptor 2, Biological Chemistry, 384, 10-11, 2003. Crossref

  21. Vuong Phat N., Berry Colin, Vascular tumours and tumour-like conditions, in The Pathology of Vessels, 2002. Crossref

  22. Husain Syed R., Puri Raj K., Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft, Blood, 95, 11, 2000. Crossref

  23. KLOUCHE M., Estrogens in Human Vascular Diseases, Annals of the New York Academy of Sciences, 1089, 1, 2006. Crossref

  24. Nickoloff Brian J., Foreman Kimberly E., Etiology and Pathogenesis of Kaposi’s Sarcoma, in Cancers of the Skin, 160, 2002. Crossref

  25. Husain Syed R., Puri Raj K., Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft, Blood, 95, 11, 2000. Crossref

  26. Greene Whitney, Kuhne Kurt, Ye Fengchun, Chen Jiguo, Zhou Fuchun, Lei Xiufeng, Gao Shou-Jiang, Molecular Biology of KSHV in Relation to AIDS-Associated Oncogenesis, in Aids-Associated Viral Oncogenesis, 133, 2007. Crossref

  27. Olefson Sidney, Vaziri Haleh, HIV and the Stomach, in HIV and GI Tract Complications, 2019. Crossref

  28. Stine Johnny T., Wood Christi, Hill Mark, Epp Angela, Raport Carol J., Schweickart Vicki L., Endo Yoshio, Sasaki Takuma, Simmons Graham, Boshoff Chris, Clapham Paul, Chang Yuan, Moore Patrick, Gray Patrick W., Chantry David, KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells, Blood, 95, 4, 2000. Crossref

  29. Wang Ena, Sabatino Marianna, Marincola Francesco M, Immunomics of Immune Rejection, in Clinical Applications of Immunomics, 2009. Crossref

  30. Hussein Mahmoud R., Immunohistological evaluation of immune cell infiltrate in cutaneous Kaposi's sarcoma, Cell Biology International, 32, 1, 2008. Crossref

  31. Mercader Maria, Nickoloff Brian J., Foreman Kimberly E., Induction of Human Immunodeficiency Virus 1 Replication by Human Herpesvirus 8, Archives of Pathology & Laboratory Medicine, 125, 6, 2001. Crossref

  32. Arastéh Keikawus, Hannah Alison, The Role of Vascular Endothelial Growth Factor (VEGF) in AIDS-Related Kaposi's Sarcoma, The Oncologist, 5, S1, 2000. Crossref

  33. Ye Feng-Chun, Zhou Fu-Chun, Nithianantham Stanley, Chandran Bala, Yu Xiao-Lan, Weinberg Aaron, Gao Shou-Jiang, Kaposi's Sarcoma-Associated Herpesvirus Induces Rapid Release of Angiopoietin-2 from Endothelial Cells, Journal of Virology, 87, 11, 2013. Crossref

  34. Moses Ashlee V., Jarvis Michael A., Raggo Camilo, Bell Yolanda C., Ruhl Rebecca, Luukkonen B. G. Mattias, Griffith Diana J., Wait Cecily L., Druker Brian J., Heinrich Michael C., Nelson Jay A., Früh Klaus, Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c- kit Proto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells , Journal of Virology, 76, 16, 2002. Crossref

  35. Sodhi Akrit, Gutkind J. Silvio, Montaner Silvia, The kaposi’s sarcoma associated herpesvirus: a model for viral oncogenesis, Revista de Oncología, 4, 3, 2002. Crossref

  36. Sharma-Walia Neelam, Chandran Karthic, Patel Kinjan, Veettil Mohanan Valiya, Marginean Alexandru, The Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Induced 5-Lipoxygenase-Leukotriene B4 Cascade Plays Key Roles in KSHV Latency, Monocyte Recruitment, and Lipogenesis, Journal of Virology, 88, 4, 2014. Crossref

  37. Sakr Mahmoud F., Neoplastic Lesions of the Tongue, in Tongue Lesions, 2022. Crossref

Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain