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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Imprimir: 0893-9675
ISSN En Línea: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2017024841
pages 263-273

Tumor-Suppressing Properties of Crocus sativus L.: Nature as an Anti-Cancer Agent

Eleni Kakouri
Laboratory of Chemistry, Department of Food Science and Human Nutrition, School of Food Biotechnology and Development, Agricultural University of Athens, Greece
Kyriaki Hatziagapiou
First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Haematology and Oncology Unit, Athens, Greece
Kostas Bethanis
Biotechnology Department, Physics Lab, Agricultural University of Athens, Greece
Olti Alexandra Nikola
First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Haematology and Oncology Unit, Athens, Greece
George I. Lambrou
First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Haematology and Oncology Unit, Athens, Greece
Petros A. Tarantilis
Laboratory of Chemistry, Department of Food Science and Human Nutrition, School of Food Biotechnology and Development, Agricultural University of Athens, Greece

SINOPSIS

Cancer is a growing problem because it is a chronic disease that affects, not only patient health, but also its daily living. Concurrent cancer therapies have ameliorated cancer prevalence, but the severity and frequency of toxicity and side effects during therapy have led the scientific community to rediscover the possible therapeutic effectiveness of herbs and spices. Crocus sativus L., commonly known as saffron, has been used in folk medicine for centuries. Today, data from numerous in vivo and in vitro studies support its anti-cancer activity, making it a promising anti-cancer agent for study. In the present review, we focus on the anti-cancer activity of C. sativus and its derivates. Medications that are currently used as chemotherapeutic or anti-cancer agents are associated with side effects whether used at effective doses or at levels that exceed the therapeutic dose. Therefore, many cancer survivors suffer from serious and even life-threatening long- or short-term sequelae, so the development of alternative/coadjutant drugs is imperative.


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