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Critical Reviews™ in Oncogenesis
SJR: 0.946 SNIP: 0.503 CiteScore™: 2

ISSN Imprimir: 0893-9675
ISSN En Línea: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v6.i1.40
pages 47-56

Verruga Peruana: An Infectious Endemic Angiomatosis

Hector Caceres-Rios
Servicio de Dermatologia, Instituto Nacional del Niño, Av. Brasil #600, Lima 5, Peru
Juan Rodriguez-!afur
lnstituto de Investigacion, Facultad de Medicina Humana, Universidad San Martin de Porres; Laboratorios United Pharmaceutical, Lima, Peru Sociedad Peruana de Immunologia у Alergia,
Francisco Bravo-Puccio
Facultad de Medicina Humana e Universidad Peruana Cayetano Heredia, Lima, Peru
Ciro Maguina-Vargas
lnstituto de Medicina Tropical, Universidad Peruana Cayetano Heredia, Lima, Peru
Cecilia Sanguineti Diaz
lnstituto de Investigacion, Facultad de Medicina Humana, Universidad San Martin de Porres
Daniel Carrillo Ramos
Sociedad Peruana de Immunologia у Alergia
Roberto Patarca
Cordis Corporation, Miami Lakes, FL 33014


Microbial-related dysplastic and neoplastic angiomatous proliferative processes are seen with increased frequency, particularly in the acquired immunodeficiency syndrome (AIDS). The microbial-encoded or -induced mediators of angiopathogenesis in AIDS-associated Kaposi's sarcoma and bacillary angiomatosis are actively being sought. The present review addresses the historical, epidemiologic, clinical, etio- and histopathogenic aspects of the verruga peruana (VP). VP is a disease thus far endemic to high Andean valleys and characterized by dermal angioblastic proliferation in association with reactivation of latent Bartonella bacilliformis organisms. VP closely resembles AIDS-associated angiopathogenic manifestations at the clinical, histopathologic, and etiologic levels and therefore has been proposed as a model for the study of angiogenesis and endothelial cell dysplasia and neoplasia. Moreover, the recent epidemic outbreaks in endemic areas, the increased frequency of international travel to the region, the variable incubation period, and the possibility of not recognizing VP due to its rarity further underscore the relevance of studying this rare disorder and of including it in the differential diagnosis of angiomatous-proliferative disorders

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