Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Imprimir: 0893-9675
ISSN En Línea: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v20.i5-6.80
pages 349-355

Non-Small Cell Lung Cancers in Women and Men: Differences in Biology, Behavior, and Outcomes

Vei H. Mah
Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA 90095; Department of Medicine, Division of Hematology-Oncology, UCLA David Geffen School of Medicine, Los Angeles, CA

SINOPSIS

Lung cancer is the leading cause of cancer deaths in men and women, both because of its high incidence rates and poor prognosis without effective therapies. Environmental carcinogens, most predominantly tobacco smoke, play a significant role. There are continuously emerging data to suggest the biological process differs between lung cancers in men and women. Differences are seen in a variety of cellular pathways and responses to carcinogens and therapies. Particular note in this article is made of carcinogen processing by cytochrome P450s, estrogen receptor pathways, epidermal growth factor receptor mutations, and how these are not necessarily independent cellular processes. These topics are only very briefly summarized here and it was not possible to include many important references. The heterogeneity of lung cancers in men and women, as well as smokers and nonsmokers, are likely to become more apparent with further studies. Work previously done in our laboratory (EDRN, PIs David Chia & Lee Goodglick) served to further emphasize these differences. This report is dedicated to the memory of Lee Goodglick with whom I had the privilege to work for many years prior to his untimely death.


Articles with similar content:

Emerging Receptor Tyrosine Kinase Drug Targets: Implications for Antibody-Based Therapies for Oncology and Immunologic Disorders
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 5-6
Diego Alvarado, Andrew J. Garton, Theresa M. LaVallee, Gerald McMahon, E. Sergio Trombetta, Richard Gedrich
Linking Autophagy and the Dysregulated NFκB/ SNAIL/YY1/RKIP/PTEN Loop in Cancer: Therapeutic Implications
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 5-6
Benjamin Bonavida
Yin Yang 1 (YY1): Regulation of Survivin and Its Role In Invasion and Metastasis
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Nicholas R. Galloway, Kathryn F. Ball, Nathan R. Wall, TessaRae Stiff
Precise Diagnosis and Treatment of Thymic Epithelial Tumors Based on Molecular Biomarkers
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 5-6
Jun Du, Xiao-Jun Zhou
Acetylcholine Release from the Central Nervous System: A 50-Year Retrospective
Critical Reviews™ in Neurobiology, Vol.17, 2005, issue 3-4
John W. Phillis