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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Imprimir: 0893-9675
ISSN En Línea: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v20.i5-6.140
pages 435-447

Review of the GAS3 Family of Proteins and their Relevance to Cancer

Negin Ashki
Department of Ophthalmology, Jules Stein Eye Institute, Los Angeles, CA
Lynn Gordon
Department of Ophthalmology, Jules Stein Eye Institute, Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
Madhuri Wadehra
Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA; Center to Eliminate Cancer Health Disparities, Charles Drew University, Los Angeles, CA

SINOPSIS

The GAS3 family of tetraspan proteins has recently been implicated in the progression of cancer. Currently, six members of the GAS3 family have been identified in humans and mice, and while their expressions in disease vary, data suggest that they play a role in epithelial cell structure and function. In this review, we highlight the studies implicating four of the members in disease pathogenesis as well as probe the structural similarities between the family members. Finally, the impact of targeting select members of the family such as PMP22 and EMP2 is discussed.


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