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MEASUREMENT OF THE HYDRAULIC CONDUCTIVITY OF THE VITREOUS HUMOR

Volumen 23, Edición 2, 2020, pp. 195-206
DOI: 10.1615/JPorMedia.2020028229
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SINOPSIS

The hydraulic conductivity of the vitreous humor has been measured for the bovine eye. The experiment was carried out by placing the vitreous within an upright cylindrical chamber, open at both ends, and letting its liquid content drain out of the bottom opening by gravity through a 20-μm nylon mesh filter. Additional negative pressure was provided at the exit by a hanging drainage tube. The diminishing vitreous volume was measured in terms of the height in the chamber and recorded as a function of time. The reduction in the vitreous liquid content also caused the hydraulic conductivity to reduce, and this parameter was quantified on the basis of previously developed theories of fibrous porous media that have been very well established. A theoretical model with a fully analytical expression for the vitreous volume undergoing drainage was developed and used as a least-squares best fit to deliver the initial hydraulic conductivity value of K0/μ = (7.8 ± 3.1) × 10-12 m2/(Pa s). The measurements were made with the hyaloid membrane intact and therefore represent an effective conductivity for the entire system, including possible variations within the vitreous.

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CITADO POR
  1. Zhang Shuqi, Penkova Anita, Humayun Mark S., Martinez-Camarillo Juan Carlos, Tadle Abegail C., Galesic Ana, Thompson Mark E., Pratt Matthew, Gonzales-Calle Alejandra, Sadhal Satwindar Singh, In Vivo Experimental and Analytical Studies for Bevacizumab Diffusion Coefficient Measurement in the Rabbit Vitreous Humor, Journal of Heat Transfer, 143, 3, 2021. Crossref

  2. Khoobyar Anahid, Naghdloo Amin, Penkova Anita N., Humayun Mark S., Sadhal Satwindar Singh, Analytical and Computational Modeling of Sustained-Release Drug Implants in the Vitreous Humor, Journal of Heat Transfer, 143, 10, 2021. Crossref

  3. Bhandari Ajay, Ocular Fluid Mechanics and Drug Delivery: A Review of Mathematical and Computational Models, Pharmaceutical Research, 38, 12, 2021. Crossref

  4. Khoobyar Anahid, Penkova Anita N., Humayun Mark S., Sadhal Satwindar Singh, Mathematical Model of Macromolecular Drug Transport in a Partially Liquefied Vitreous Humor, Journal of Heat Transfer, 144, 3, 2022. Crossref

  5. Bayat Javad, Emdad Homayoun, Abouali Omid, A mechanical model of partially liquefied vitreous dynamics induced by saccadic eye movement within a realistic shape of vitreous cavity, Physics of Fluids, 34, 2, 2022. Crossref

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