Publicado 6 números por año
ISSN Imprimir: 0278-940X
ISSN En Línea: 1943-619X
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Novel Approaches of CRISPR-Cas Technology in Airway Diseases
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SINOPSIS
Clustered regularly interspaced palindromic repeats (CRISPR) technique plays a vital role in preclinical modelling of many respiratory diseases. Diseases such as chronic obstructive pulmonary disease (COPD), asthma, acute tracheal bronchitis, pneumonia, tuberculosis, lung cancer, and influenza infection continue to significantly impact human health. CRISPR associated (Cas) proteins, isolated from the immune system of prokaryotes, are one component of a very useful technique to manipulate gene sequences or editing and gene expression with significant implications for respiratory research in the field of molecular biology. CRISPR technology is a promising tool that is easily adaptable for specific editing of DNA sequences of interest with a goal towards modifying or eliminating gene function. Among its many potential applications, CRISPR can be applied to correcting genetic defects as well as for therapeutic approaches for treatment. This review elucidates recent advances in CRISPR-Cas technology in airway diseases.
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M a k a r o v a K S , H a f t D H , B a r r a n g o u R , B r o u n s S J J , C h a r p e n t i e r E , H o r v a t h P , M o i n e a u S , M o j i c a F J M , W o l f Y I , Y a k u n i n A F , v a n d e r O o s t J , K o o n i n E V . E v o l u t i o n a n d c l a s s i f i c a t i o n o f t h e C R I S P R - C a s s y s t e m s . N a t R e v M i c r o b i o l . 2 0 1 1 ; 9 ( 6 ) : 4 6 7 7 7 . P u b M e d P M I D : 2 1 5 5 2 2 8 6 . P u b m e d C e n t r a l P M C I D : 3 3 8 0 4 4 4 . .
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C h o S W , K i m S , K i m J M , K i m J S . T a r g e t e d g e n o m e e n g i n e e r i n g i n h u m a n c e l l s w i t h t h e C a s 9 R N A - g u i d e d e n d o n u c l e a s e . N a t B i o t e c h n o l . 2 0 1 3 ; 3 1 ( 3 ) : 2 3 0 - 2 . P u b M e d P M I D : 2 3 3 6 0 9 6 6 . .
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C o n g L , R a n F A , C o x D , L i n S , B a r r e t t o R , H a b i b N , H s u P D , W u X , J i a n g W , M a r r a f f i n i L A , Z h a n g F . M u l t i p l e x g e n o m e e n g i n e e r i n g u s i n g C R I S P R / C a s s y s t e m s . S c i e n c e . 2 0 1 3 ; 3 3 9 ( 6 1 2 1 ) : 8 1 9 - 2 3 . P u b M e d P M I D : 2 3 2 8 7 7 1 8 . P u b m e d C e n t r a l P M C I D : 3 7 9 5 4 1 1 . .
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J i n e k M , C h y l i n s k i K , F o n f a r a I , H a u e r M , D o u d n a J A , C h a r p e n t i e r E . A p r o g r a m m a b l e d u a l - R N A - g u i d e d D N A e n d o n u c l e a s e i n a d a p t i v e b a c t e r i a l i m m u n i t y . S c i e n c e . 2 0 1 2 ; 3 3 7 ( 6 0 9 6 ) : 8 1 6 - 2 1 . P u b M e d P M I D : 2 2 7 4 5 2 4 9 . P u b m e d C e n t r a l P M C I D : 6 2 8 6 1 4 8 . .
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M a l i P , Y a n g L , E s v e l t K M , A a c h J , G u e l l M , D i C a r l o J E , N o r v i l l e J E , C h u r c h G M . R N A - g u i d e d h u m a n g e n o m e e n g i n e e r i n g v i a C a s 9 . S c i e n c e . 2 0 1 3 ; 3 3 9 ( 6 1 2 1 ) : 8 2 3 - 6 . P u b M e d P M I D : 2 3 2 8 7 7 2 2 . P u b m e d C e n t r a l P M C I D : 3 7 1 2 6 2 8 . .
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J a n s e n R , E m b d e n J D , G a a s t r a W , S c h o u l s L M . I d e n t i f i c a t i o n o f g e n e s t h a t a r e a s s o c i a t e d w i t h D N A r e p e a t s i n p r o k a r y o t e s . M o l M i c r o b i o l . 2 0 0 2 ; 4 3 ( 6 ) : 1 5 6 5 - 7 5 . P u b M e d P M I D : 1 1 9 5 2 9 0 5 . .
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H a f t D H , S e l e n g u t J , M o n g o d i n E F , N e l s o n K E . A g u i l d o f 4 5 C R I S P R - a s s o c i a t e d ( C a s ) p r o t e i n f a m i l i e s a n d m u l t i p l e C R I S P R / C a s s u b t y p e s e x i s t i n p r o k a r y o t i c g e n o m e s . P L o S C o m p B i o l . 2 0 0 5 ; 1 ( 6 ) : e 6 0 . P u b M e d P M I D : 1 6 2 9 2 3 5 4 . P u b m e d C e n t r a l P M C I D : 1 2 8 2 3 3 3 . .
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K o o n i n E V , M a k a r o v a K S , Z h a n g F . D i v e r s i t y , c l a s s i f i c a t i o n a n d e v o l u t i o n o f C R I S P R - C a s s y s t e m s . C u r r O p i n M i c r o b i o l . 2 0 1 7 ; 3 7 : 6 7 - 7 8 . P u b M e d P M I D : 2 8 6 0 5 7 1 8 . P u b m e d C e n t r a l P M C I D : 5 7 7 6 7 1 7 . .
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K o o n i n E V , M a k a r o v a K S . O r i g i n s a n d e v o l u t i o n o f C R I S - P R - C a s s y s t e m s . P h i l o s T r a n s R S o c L o n d B B i o l S c i . 2 0 1 9 ; 3 7 4 ( 1 7 7 2 ) : 2 0 1 8 0 0 8 7 . P u b M e d P M I D : 3 0 9 0 5 2 8 4 . P u b m e d C e n t r a l P M C I D : 6 4 5 2 2 7 0 . .
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M a k a r o v a K S , W o l f Y I , A l k h n b a s h i O S , C o s t a F , S h a h S A , S a u n d e r s S J , B a r r a n g o u R , B r o u n s S J , C h a r p e n t i e r E , H a f t D H , H o r v a t h P , M o i n e a u S , M o j i c a F J , T e r n s R M , T e r n s M P , W h i t e M F , Y a k u n i n A F , G a r r e t t R A , v a n d e r O o s t J , B a c k o f e n R , K o o n i n E V . A n u p d a t e d e v o l u t i o n a r y c l a s s i f i c a t i o n o f C R I S P R - C a s s y s t e m s . N a t R e v M i c r o b i o l . 2 0 1 5 ; 1 3 ( 1 1 ) : 7 2 2 - 3 6 . P u b M e d P M I D : 2 6 4 1 1 2 9 7 . P u b m e d C e n t r a l P M C I D : 5 4 2 6 1 1 8 . .
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G o d d e J S , B i c k e r t o n A . T h e r e p e t i t i v e D N A e l e m e n t s c a l l e d C R I S P R s a n d t h e i r a s s o c i a t e d g e n e s : E v i d e n c e o f h o r i z o n t a l t r a n s f e r a m o n g p r o k a r y o t e s . J M o l E v o l . 2 0 0 6 ; 6 2 ( 6 ) : 7 1 8 - 2 9 . P u b M e d P M I D : 1 6 6 1 2 5 3 7 . .
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W r i g h t A V , N u n e z J K , D o u d n a J A . B i o l o g y a n d a p p l i c a t i o n s o f C R I S P R s y s t e m s : H a r n e s s i n g n a t u r e ' s t o o l b o x f o r g e n o m e e n g i n e e r i n g . C e l l . 2 0 1 6 ; 1 6 4 ( 1 - 2 ) : 2 9 - 4 4 . P u b M e d P M I D : 2 6 7 7 1 4 8 4 . .
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G a s i u n a s G , B a r r a n g o u R , H o r v a t h P , S i k s n y s V . C a s 9 - c r R N A r i b o n u c l e o p r o t e i n c o m p l e x m e d i a t e s s p e c i f i c D N A c l e a v a g e f o r a d a p t i v e i m m u n i t y i n b a c t e r i a . P r o c N a t l A c a d S c i U S A . 2 0 1 2 ; 1 0 9 ( 3 9 ) : E 2 5 7 9 - 8 6 . P u b M e d P M I D : 2 2 9 4 9 6 7 1 . P u b m e d C e n t r a l P M C I D : 3 4 6 5 4 1 4 . .
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W a r y a h C B , M o s e s C , A r o o j M , B l a n c a f o r t P . Z i n c f i n g e r s , T A L E s , a n d C R I S P R s y s t e m s : A c o m p a r i s o n o f t o o l s f o r e p i g e n o m e e d i t i n g . M e t h o d s M o l B i o l . 2 0 1 8 ; 1 7 6 7 : 1 9 - 6 3 . P u b M e d P M I D : 2 9 5 2 4 1 2 8 . .
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C o x D B T , G o o t e n b e r g J S , A b u d a y y e h O O , F r a n k l i n B , K e l l n e r M J , J o u n g J , Z h a n g F . R N A e d i t i n g w i t h C R I S - P R - C a s 1 3 . S c i e n c e . 2 0 1 7 ; 3 5 8 ( 6 3 6 6 ) : 1 0 1 9 - 2 7 . P u b M e d P M I D : 2 9 0 7 0 7 0 3 . P u b m e d C e n t r a l P M C I D : 5 7 9 3 8 5 9 . .
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O a k e s B L , N a d l e r D C , S a v a g e D F . P r o t e i n e n g i n e e r i n g o f C a s 9 f o r e n h a n c e d f u n c t i o n . M e t h o d s E n z y m o l . 2 0 1 4 ; 5 4 6 : 4 9 1 - 5 1 1 . P u b M e d P M I D : 2 5 3 9 8 3 5 5 . P u b m e d C e n t r a l P M C I D : 4 6 4 1 0 7 1 . .
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L o z a n o R , N a g h a v i M , F o r e m a n K , L i m S , S h i b u y a K , A b o y a n s V , A b r a h a m J , A d a i r T , A g g a r w a l R , A h n S Y , A l v a r a d o M , A n d e r s o n H R , A n d e r s o n L M , A n d r e w s K G , A t k i n s o n C , B a d d o u r L M , B a r k e r - C o l l o S , B a r t e l s D H , B e l l M L , B e n j a m i n E J , B e n n e t t D , B h a l l a K , B i k b o v B , B i n A b d u l h a k A , B i r b e c k G , B l y t h F , B o l l i g e r I , B o u f o u s S , B u c e l l o C , B u r c h M , B u r n e y P , C a r a p e t i s J , C h e n H , C h o u D , C h u g h S S , C o f f e n g L E , C o l a n S D , C o l q u h o u n S , C o l s o n K E , C o n d o n J , C o n n o r M D , C o o p e r L T , C o r r i e r e M , C o r t i n o v i s M , d e V a c c a r o K C , C o u s e r W , C o w i e B C , C r i q u i M H , C r o s s M , D a b h a d k a r K C , D a h o d w a l a N , D e L e o D , D e g e n h a r d t L , D e l o s s a n t o s A , D e n e n b e r g J , D e s J a r l a i s D C , D h a r m a r a t n e S D , D o r s e y E R , D r i s c o l l T , D u b e r H , E b e l B , E r w i n P J , E s p i n d o l a P , E z z a t i M , F e i g i n V , F l a x m a n A D , F o r o u z a n f a r M H , F o w k e s F G , F r a n k l i n R , F r a n s e n M , F r e e m a n M K , G a b r i e l S E , G a k i d o u E , G a s p a r i F , G i l l u m R F , G o n z a l e z - M e d i n a D , H a l a s a Y A , H a r i n g D , H a r r i s o n J E , H a v m o e l l e r R , H a y R J , H o e n B , H o t e z P J , H o y D , J a c o b s e n K H , J a m e s S L , J a s r a s a r i a R , J a y a r a m a n S , J o h n s N , K a r t h i k e y a n G , K a s s e b a u m N , K e r e n A , K h o o J P , K n o w l t o n L M , K o b u s i n g y e O , K o r a n t e n g A , K r i s h n a m u r t h i R , L i p n i c k M , L i p s h u l t z S E , O h n o S L , M a b w e i j a n o J , M a c I n t y r e M F , M a l l i n g e r L , M a r c h L , M a r k s G B , M a r k s R , M a t s u m o r i A , M a t z o p o u l o s R , M a y o s i B M , M c A n u l t y J H , M c D e r m o t t M M , M c G r a t h J , M e n s a h G A , M e r r i m a n T R , M i c h a u d C , M i l l e r M , M i l l e r T R , M o c k C , M o c u m b i A O , M o k d a d A A , M o r a n A , M u l h o l l a n d K , N a i r M N , N a l d i L , N a r a y a n K M , N a s s e r i K , N o r m a n P , O ' D o n n e l l M , O m e r S B , O r t b l a d K , O s b o r n e R , O z g e d i z D , P a - h a r i B , P a n d i a n J D , R i v e r o A P , P a d i l l a R P , P e r e z - R u i z F , P e r i c o N , P h i l l i p s D , P i e r c e K , P o p e C A 3 r d , P o r r i n i E , P o u r m a l e k F , R a j u M , R a n g a n a t h a n D , R e h m J T , R e i n D B , R e m u z z i G , R i v a r a F P , R o b e r t s T , D e L e o n F R , R o s e n f e l d L C , R u s h t o n L , S a c c o R L , S a l o m o n J A , S a m p s o n U , S a n m a n E , S c h w e b e l D C , S e g u i - G o m e z M , S h e p a r d D S , S i n g h D , S i n g l e t o n J , S l i w a K , S m i t h E , S t e e r A , T a y l o r J A , T h o m a s B , T l e y j e h I M , T o w b i n J A , T r u e l s e n T , U n d u r r a g a E A , V e n k e t a s u b r a m a n i a n N , V i j a y a k u m a r L , V o s T , W a g n e r G R , W a n g M , W a n g W , W a t t K , W e i n s t o c k M A , W e i n t r a u b R , W i l k i n s o n J D , W o o l f A D , W u l f S , Y e h P H , Y i p P , Z a b e t i a n A , Z h e n g Z J , L o p e z A D , M u r r a y C J , A l M a z r o a M A , M e m i s h Z A . G l o b a l a n d r e g i o n a l m o r t a l i t y f r o m 2 3 5 c a u s e s o f d e a t h f o r 2 0 a g e g r o u p s i n 1 9 9 0 a n d 2 0 1 0 : A s y s t e m a t i c a n a l y s i s f o r t h e G l o b a l B u r d e n o f D i s e a s e S t u d y 2 0 1 0 . L a n c e t . 2 0 1 2 ; 3 8 0 ( 9 8 5 9 ) : 2 0 9 5 - 1 2 8 . P u b M e d P M I D : 2 3 2 4 5 6 0 4 . .
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V e s t b o J . C O P D : D e f i n i t i o n a n d p h e n o t y p e s . C l i n C h e s t M e d . 2 0 1 4 ; 3 5 ( 1 ) : 1 - 6 . P u b M e d P M I D : 2 4 5 0 7 8 3 2 . .
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M o n t e s d e O c a M , P e r e z - P a d i l l a R . G l o b a l i n i t i a t i v e f o r c h r o n i c o b s t r u c t i v e l u n g d i s e a s e ( G O L D ) - 2 0 1 7 : T h e a l a t p e r s p e c t i v e . A r c h B r o n c o n e u m o l . 2 0 1 7 ; 5 3 ( 3 ) : 8 7 - 8 . P u b M e d P M I D : 2 8 2 2 2 9 3 5 . .
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K i m E J , Y o o n S J , K i m Y E , G o D S , J u n g Y . E f f e c t s o f a g i n g a n d s m o k i n g d u r a t i o n o n c i g a r e t t e s m o k e - i n d u c e d C O P D s e v e r i t y . J K o r e a n M e d S c i . 2 0 1 9 ; 3 4 ( S u p p l 1 ) : e 9 0 . P u b M e d P M I D : 3 0 9 2 3 4 9 3 . P u b m e d C e n t r a l P M C I D : 6 4 3 4 1 4 6 . .
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B o o t c o v M R , B a u s k i n A R , V a l e n z u e l a S M , M o o r e A G , B a n s a l M , H e X Y , Z h a n g H P , D o n n e l l a n M , M a h l e r S , P r y o r K , W a l s h B J , N i c h o l s o n R C , F a i r l i e W D , P o r S B , R o b b i n s J M , B r e i t S N . M I C - 1 , a n o v e l m a c r o p h a g e i n h i b i t o r y c y t o k i n e , i s a d i v e r g e n t m e m b e r o f t h e T G F - P s u p e r - f a m i l y . P r o c N a t l A c a d S c i U S A . 1 9 9 7 ; 9 4 ( 2 1 ) : 1 1 5 1 4 - 9 . P u b M e d P M I D : 9 3 2 6 6 4 1 . P u b m e d C e n t r a l P M C I D : 2 3 5 2 3 . .
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W u Q , J i a n g D , M a t s u d a J L , T e r n y a k K , Z h a n g B , C h u H W . C i g a r e t t e s m o k e i n d u c e s h u m a n a i r w a y e p i t h e l i a l s e n e s c e n c e v i a g r o w t h d i f f e r e n t i a t i o n f a c t o r 1 5 p r o d u c t i o n . A m J R e s p i r C e l l M o l B i o l . 2 0 1 6 ; 5 5 ( 3 ) : 4 2 9 - 3 8 . P u b M e d P M I D : 2 7 0 9 3 4 7 5 . .
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C h u H W , R i o s C , H u a n g C , W e s o l o w s k a - A n d e r s e n A , B u r c h a r d E G , O ' C o n n o r B P , F i n g e r l i n T E , N i c h o l s D , R e y n o l d s S D , S e i b o l d M A . C R I S P R - C a s 9 - m e d i a t e d g e n e k n o c k o u t i n p r i m a r y h u m a n a i r w a y e p i t h e l i a l c e l l s r e v e a l s a p r o i n f l a m m a t o r y r o l e f o r M U C 1 8 . G e n e T h e r . 2 0 1 5 ; 2 2 ( 1 0 ) : 8 2 2 - 9 . P u b M e d P M I D : 2 6 0 4 3 8 7 2 . P u b m e d C e n t r a l P M C I D : 4 6 0 0 0 1 1 . .
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S t o l z e n b u r g L R , H a r r i s A . M i c r o v e s i c l e - m e d i a t e d d e l i v e r y o f m i R - 1 3 4 3 : I m p a c t o n m a r k e r s o f f i b r o s i s . C e l l T i s s R e s . 2 0 1 8 ; 3 7 1 ( 2 ) : 3 2 5 - 3 8 . P u b M e d P M I D : 2 9 0 2 2 1 4 2 . P u b m e d C e n t r a l P M C I D : 5 8 0 9 3 0 4 . .
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Z h a n g Y H , W u L Z , L i a n g H L , Y a n g Y , Q i u J , K a n Q , Z h u W , M a C L , Z h o u X Y . P u l m o n a r y s u r f a c t a n t s y n t h e s i s i n m i R N A - 2 6 a - 1 / m i R N A - 2 6 a - 2 d o u b l e k n o c k o u t m i c e g e n - e r a t e d u s i n g t h e C R I S P R / C a s 9 s y s t e m . A m J T r a n s l R e s . 2 0 1 7 ; 9 ( 2 ) : 3 5 5 - 6 5 . P u b M e d P M I D : 2 8 3 3 7 2 6 5 . P u b m e d C e n t r a l P M C I D : 5 3 4 0 6 7 2 . .
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W a n g S , S a m a k o v l i s C . G r a i n y h e a d a n d i t s t a r g e t g e n e s i n e p i t h e l i a l m o r p h o g e n e s i s a n d w o u n d h e a l i n g . C u r r T o p D e v B i o l . 2 0 1 2 ; 9 8 : 3 5 - 6 3 . P u b M e d P M I D : 2 2 3 0 5 1 5 8 . .
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G a o X , B a l i A S , R a n d e l l S H , H o g a n B L . G R H L 2 c o o r d i n a t e s r e g e n e r a t i o n o f a p o l a r i z e d m u c o c i l i a r y e p i t h e l i u m f r o m b a s a l s t e m c e l l s . J C e l l B i o l . 2 0 1 5 ; 2 1 1 ( 3 ) : 6 6 9 - 8 2 . P u b M e d P M I D : 2 6 5 2 7 7 4 2 . P u b m e d C e n t r a l P M C I D : 4 6 3 9 8 6 1 . .
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U n w a l l a H J , I v o n n e t P , D e n n i s J S , C o n n e r G E , S a l a t h e M . T r a n s f o r m i n g g r o w t h f a c t o r - P 1 a n d c i g a r e t t e s m o k e i n h i b i t t h e a b i l i t y o f P 2 - a g o n i s t s t o e n h a n c e e p i t h e l i a l p e r m e a b i l i t y . A m J R e s p i r C e l l M o l B i o l . 2 0 1 5 ; 5 2 ( 1 ) : 6 5 - 7 4 . P u b M e d P M I D : 2 4 9 7 8 1 8 9 . P u b m e d C e n t r a l P M C I D : 4 3 7 0 2 5 2 . .
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C o n n e r G E , S a l a t h e M , F o r t e z a R . L a c t o p e r o x i d a s e a n d h y d r o g e n p e r o x i d e m e t a b o l i s m i n t h e a i r w a y . A m J R e s p i r C r i t C a r e M e d . 2 0 0 2 ; 1 6 6 ( 1 2 P t 2 ) : S 5 7 - 6 1 . P u b M e d P M I D : 1 2 4 7 1 0 9 0 . E p u b 2 0 0 2 / 1 2 / 1 0 . e n g . .
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C o n n e r G E , W i j k s t r o m - F r e i C , R a n d e l l S H , F e r n a n d e z V E , S a l a t h e M . T h e l a c t o p e r o x i d a s e s y s t e m l i n k s a n i o n t r a n s p o r t t o h o s t d e f e n s e i n c y s t i c f i b r o s i s . F E B S L e t t . 2 0 0 7 ; 5 8 1 ( 2 ) : 2 7 1 - 8 . P u b M e d P M I D : 1 7 2 0 4 2 6 7 . P u b m e d C e n t r a l P M C I D : 1 8 5 1 6 9 4 . E p u b 2 0 0 7 / 0 1 / 0 6 . e n g . .
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V a i d y a n a t h a n S , S a l a h u d e e n A A , S e l l e r s Z M , B r a v o D T , C h o i S S , B a t i s h A , L e W , B a i k R , d e l a O S , K a u s h i k M P , G a l p e r N , L e e C M , T e r a n C A , Y o o J H , B a o G , C h a n g E H , P a t e l Z M , H w a n g P H , W i n e J J , M i l l a C E , D e s a i T J , N a y a k J V , K u o C J , P o r t e u s M H . H i g h - e f f i c i e n c y , s e l e c t i o n - f r e e g e n e r e p a i r i n a i r w a y s t e m c e l l s f r o m c y s t i c f i b r o s i s p a t i e n t s r e s c u e s C F T R f u n c t i o n i n d i f f e r e n t i a t e d e p i t h e l i a . C e l l S t e m C e l l . 2 0 2 0 ; 2 6 ( 2 ) : 1 6 1 - 7 1 . P u b M e d P M I D : 3 1 8 3 9 5 6 9 . .
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E l b o r n J S . P e r s o n a l i s e d m e d i c i n e f o r c y s t i c f i b r o s i s : T r e a t i n g t h e b a s i c d e f e c t . E u r R e s p i r R e v . 2 0 1 3 ; 2 2 ( 1 2 7 ) : 3 - 5 . P u b M e d P M I D : 2 3 4 5 7 1 5 8 . .
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C l a n c y J P , C o t t o n C U , D o n a l d s o n S H , S o l o m o n G M , V a n - D e v a n t e r D R , B o y l e M P , G e n t z s c h M , N i c k J A , I l l e k B , W a l l e n b u r g J C , S o r s c h e r E J , A m a r a l M D , B e e k m a n J M , N a r e n A P , B r i d g e s R J , T h o m a s P J , C u t t i n g G , R o w e S , D u r m o w i c z A G , M e n s e M , B o e c k K D , S k a c h W , P e n l a n d C , J o s e l o f f E , B i h l e r H , M a h o n e y J , B o r o w i t z D , T u g g l e K L . C F T R m o d u l a t o r t h e r a t y p i n g : C u r r e n t s t a t u s , g a p s a n d f u t u r e d i r e c t i o n s . J C y s t F i b r o s . 2 0 1 9 ; 1 8 ( 1 ) : 2 2 - 3 4 . P u b M e d P M I D : 2 9 9 3 4 2 0 3 . P u b m e d C e n t r a l P M C I D : 6 3 0 1 1 4 3 . .
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C a s t e l l a n i C , C F T R 2 T e a m . C F T R 2 : H o w w i l l i t h e l p c a r e ? P a e d i a t r R e s p i r R e v . 2 0 1 3 ; 1 4 ( S u p p l 1 ) : 2 - 5 . P u b M e d P M I D : 2 3 4 6 6 3 4 0 . .
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M a r a n g i M , P i s t r i t t o G . I n n o v a t i v e t h e r a p e u t i c s t r a t e g i e s f o r c y s t i c f i b r o s i s : M o v i n g f o r w a r d t o C R I S P R t e c h n i q u e . F r o n t P h a r m a c o l . 2 0 1 8 ; 9 : 3 9 6 . P u b M e d P M I D : 2 9 7 3 1 7 1 7 . P u b m e d C e n t r a l P M C I D : 5 9 2 0 6 2 1 . .
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H o l l y w o o d J A , L e e C M , S c a l l a n M F , H a r r i s o n P T . A n a l y s i s o f g e n e r e p a i r t r a c t s f r o m C a s 9 / g R N A d o u b l e - s t r a n d e d b r e a k s i n t h e h u m a n C F T R g e n e . S c i R e p . 2 0 1 6 ; 6 : 3 2 2 3 0 . P u b M e d P M I D : 2 7 5 5 7 5 2 5 . P u b m e d C e n t r a l P M C I D : 4 9 9 7 5 6 0 . .
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K u n z e l m a n n K , S c h w i e b e r t E M , Z e i t l i n P L , K u o W L , S t a n t o n B A , G r u e n e r t D C . A n i m m o r t a l i z e d c y s t i c f i b r o s i s t r a c h e a l e p i t h e l i a l c e l l l i n e h o m o z y g o u s f o r t h e A F 5 0 8 C F T R m u t a t i o n . A m J R e s p i r C e l l M o l B i o l . 1 9 9 3 ; 8 ( 5 ) : 5 2 2 - 9 . P u b M e d P M I D : 7 6 8 3 1 9 7 . .
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S a n z D J , H o l l y w o o d J A , S c a l l a n M F , H a r r i s o n P T . C a s 9 / g R N A t a r g e t e d e x c i s i o n o f c y s t i c f i b r o s i s - c a u s i n g d e e p - i n t r o n i c s p l i c i n g m u t a t i o n s r e s t o r e s n o r m a l s p l i c i n g o f C F T R m R N A . P L o S O n e . 2 0 1 7 ; 1 2 ( 9 ) : e 0 1 8 4 0 0 9 . P u b M e d P M I D : 2 8 8 6 3 1 3 7 . P u b m e d C e n t r a l P M C I D : 5 5 8 1 1 6 4 . .
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R o s e n B H , C h a n s o n M , G a w e n i s L R , L i u J , S o f o l u w e A , Z o s o A , E n g e l h a r d t J F . A n i m a l a n d m o d e l s y s t e m s f o r s t u d y i n g c y s t i c f i b r o s i s . J C y s t F i b r o s . 2 0 1 8 ; 1 7 ( 2 S ) : S 2 8 - 3 4 . P u b M e d P M I D : 2 8 9 3 9 3 4 9 . P u b m e d C e n t r a l P M C I D : 5 8 2 8 9 4 3 . .
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M u r d o c h J R , L l o y d C M . C h r o n i c i n f l a m m a t i o n a n d a s t h m a . M u t a t R e s . 2 0 1 0 ; 6 9 0 ( 1 - 2 ) : 2 4 - 3 9 . P u b M e d P M I D : 1 9 7 6 9 9 9 3 . E p u b 0 9 / 1 9 . e n g . .
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D h a r m a g e S C , P e r r e t J L , C u s t o v i c A . E p i d e m i o l o g y o f a s t h m a i n c h i l d r e n a n d a d u l t s . F r o n t P e d i a t r . 2 0 1 9 ; 7 : 2 4 6 . P u b M e d P M I D : 3 1 2 7 5 9 0 9 . e n g . .
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B r a m a n S S . T h e g l o b a l b u r d e n o f a s t h m a . C h e s t . 2 0 0 6 ; 1 3 0 ( 1 S u p p l ) : 4 S - 1 2 S . P u b M e d P M I D : 1 6 8 4 0 3 6 3 . E p u b 2 0 0 6 / 0 7 / 1 5 . e n g . .
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N u n e s C , P e r e i r a A M , M o r a i s - A l m e i d a M . A s t h m a c o s t s a n d s o c i a l i m p a c t . A s t h m a R e s P r a c t . 2 0 1 7 ; 3 : 1 . P u b M e d P M I D : 2 8 0 7 8 1 0 0 . e n g . .
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T r e v o r J L , C h i p p s B E . S e v e r e a s t h m a i n p r i m a r y c a r e : I d e n t i f i c a t i o n a n d m a n a g e m e n t . A m J M e d . 2 0 1 8 ; 1 3 1 ( 5 ) : 4 8 4 - 9 1 . .
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R a b e K F , S c h m i d t D T . P h a r m a c o l o g i c a l t r e a t m e n t o f a s t h m a t o d a y . E u r R e s p i r J . 2 0 0 1 ; 1 8 ( 3 4 S u p p l ) : 3 4 s - 4 0 s . .
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G o o d m a n M A , M o r a d i M a n e s h D , M a l i k P , R o t h e n b e r g M E . C R I S P R / C a s 9 i n a l l e r g i c a n d i m m u n o l o g i c d i s e a s e s . E x p e r t R e v C l i n I m m u n o l . 2 0 1 7 ; 1 3 ( 1 ) : 5 - 9 . P u b M e d P M I D : 2 7 6 8 7 5 7 2 . E p u b 1 0 / 2 4 . e n g . .
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S i m o n G C , M a r t i n R J , S m i t h S , T h a i k o o t t a t h i l J , B o w l e r R P , B a r e n k a m p S J , C h u H W . U p - r e g u l a t i o n o f M U C 1 8 i n a i r w a y e p i t h e l i a l c e l l s b y I L - 1 3 : I m p l i c a t i o n s i n b a c t e r i a l a d h e r e n c e . A m J R e s p i r C e l l M o l B i o l . 2 0 1 1 ; 4 4 ( 5 ) : 6 0 6 - 1 3 . P u b M e d P M I D : 2 1 2 3 9 6 0 4 . P u b m e d C e n t r a l P M C I D : P M C 3 0 9 5 9 8 1 . E p u b 2 0 1 1 / 0 1 / 1 8 . e n g . .
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C h u H W , R i o s C , H u a n g C , W e s o l o w s k a - A n d e r s e n A , B u r c h a r d E G , O ' C o n n o r B P , F i n g e r l i n T E , N i c h o l s D , R e y n o l d s S D , S e i b o l d M A . C R I S P R - C a s 9 - m e d i a t e d g e n e k n o c k o u t i n p r i m a r y h u m a n a i r w a y e p i t h e l i a l c e l l s r e v e a l s a p r o i n f l a m m a t o r y r o l e f o r M U C 1 8 . G e n e T h e r . 2 0 1 5 ; 2 2 ( 1 0 ) : 8 2 2 - 9 . .
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L a m b e r t K A , P r e n d e r g a s t L A , D h a r m a g e S C , T a n g M , O ' S u l l i v a n M , T r a n T , D r u c e J , B a r d i n P , A b r a m s o n M J , E r b a s B . T h e r o l e o f h u m a n r h i n o v i r u s ( H R V ) s p e c i e s o n a s t h m a e x a c e r b a t i o n s e v e r i t y i n c h i l d r e n a n d a d o l e s c e n t s . J A s t h m a . 2 0 1 8 ; 5 5 ( 6 ) : 5 9 6 - 6 0 2 . P u b M e d P M I D : 2 9 0 2 0 4 6 3 . E p u b 2 0 1 7 / 1 0 / 1 2 . e n g . .
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W a t t e r s K , P a l m e n b e r g A C . C D H R 3 e x t r a c e l l u l a r d o m a i n s E C 1 - 3 m e d i a t e r h i n o v i r u s C i n t e r a c t i o n w i t h c e l l s a n d a s r e c o m b i n a n t d e r i v a t i v e s , a r e i n h i b i t o r y t o v i r u s i n f e c t i o n . P L o S P a t h o g . 2 0 1 8 ; 1 4 ( 1 2 ) : e 1 0 0 7 4 7 7 . .
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E v e r m a n J L , S a j u t h i S , S a e f B , R i o s C , S t o n e r A M , N u m a t a M , H u D , E n g C , O h S , R o d r i g u e z - S a n t a n a J , V l a d a r E K , V o e l k e r D R , B u r c h a r d E G , S e i b o l d M A . F u n c t i o n a l g e n o m i c s o f C D H R 3 c o n f i r m s i t s r o l e i n H R V - C i n f e c t i o n a n d c h i l d h o o d a s t h m a e x a c e r b a t i o n s . J A l l e r g y C l i n I m m u n o l . 2 0 1 9 ; 1 4 4 ( 4 ) : 9 6 2 - 7 1 . .
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B u h l R , G a r n H , R e n z H . A l l e r g e n r e s p o n s e s m o d i f i e d b y a G A T A 3 D N A z y m e . N E n g l J M e d . 2 0 1 5 ; 3 7 3 ( 1 2 ) : 1 1 7 6 - 7 . P u b M e d P M I D : 2 6 3 7 6 1 4 8 . .
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H e n r i k s s o n J , C h e n X , G o m e s T , U l l a h U , M e y e r K B , M i r a g a i a R , D u d d y G , P r a m a n i k J , Y u s a K , L a h e s m a a R , T e i c h m a n n S A . G e n o m e - w i d e C R I S P R s c r e e n s i n T h e l p e r c e l l s r e v e a l p e r v a s i v e c r o s s t a l k b e t w e e n a c t i v a t i o n a n d d i f f e r e n t i a t i o n . C e l l . 2 0 1 9 ; 1 7 6 ( 4 ) : 8 8 2 - 9 6 . e 1 8 . P u b M e d P M I D : 3 0 6 3 9 0 9 8 . E p u b 0 1 / 1 0 . e n g . .
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Y a n g H , L i S . T r a n s i e n t r e c e p t o r p o t e n t i a l a n k y r i n 1 ( T R P A 1 ) c h a n n e l a n d n e u r o g e n i c i n f l a m m a t i o n i n p a t h o g e n e s i s o f a s t h m a . M e d S c i M o n i t . 2 0 1 6 ; 2 2 : 2 9 1 7 - 2 3 . P u b M e d P M I D : 2 7 5 3 9 8 1 2 . e n g . .
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C a c e r e s A I , B r a c k m a n n M , E l i a M D , B e s s a c B F , d e l C a m i n o D , D ' A m o u r s M , W i t e k J S , F a n g e r C M , C h o n g J A , H a y w a r d N J , H o m e r R J , C o h n L , H u a n g X , M o r a n M M , J o r d t S E . A s e n s o r y n e u r o n a l i o n c h a n n e l e s s e n t i a l f o r a i r w a y i n f l a m m a t i o n a n d h y p e r r e a c t i v i t y i n a s t h m a . P r o c N a t l A c a d S c i U S A . 2 0 0 9 ; 1 0 6 ( 2 2 ) : 9 0 9 9 - 1 0 4 . P u b M e d P M I D : 1 9 4 5 8 0 4 6 . P u b m e d C e n t r a l P M C I D : P M C 2 6 8 4 4 9 8 . E p u b 2 0 0 9 / 0 5 / 2 2 . e n g . .
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R e e s e R M , D o u r a d o M , A n d e r s o n K , W a r m i n g S , S t a r k K L , B a l e s t r i n i A , S u t o E , L e e W , R i o l - B l a n c o L , S h i e l d s S D , H a c k o s D H . B e h a v i o r a l c h a r a c t e r i z a t i o n o f a C R I S - P R - g e n e r a t e d T R P A 1 k n o c k o u t r a t i n m o d e l s o f p a i n , i t c h , a n d a s t h m a . S c i R e p . 2 0 2 0 ; 1 0 ( 1 ) : 9 7 9 . .
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C h e n J , H a c k o s D H . T R P A 1 a s a d r u g t a r g e t - p r o m i s e a n d c h a l l e n g e s . N a u n y n S c h m i e d e b e r g s A r c h P h a r m a c o l . 2 0 1 5 ; 3 8 8 ( 4 ) : 4 5 1 - 6 3 . P u b M e d P M I D : 2 5 6 4 0 1 8 8 . P u b m e d C e n t r a l P M C I D : P M C 4 3 5 9 7 1 2 . E p u b 2 0 1 5 / 0 2 / 0 3 . e n g . .
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S h a r m a N , T r i p a t h i P , A w a s t h i S . R o l e o f A D A M 3 3 g e n e a n d a s s o c i a t e d s i n g l e n u c l e o t i d e p o l y m o r p h i s m s i n a s t h m a . A l l e r g y R h i n o l ( P r o v i d e n c e ) . 2 0 1 1 ; 2 ( 2 ) : e 6 3 - 7 0 . P u b M e d P M I D : 2 2 8 5 2 1 2 1 . e n g . .
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W a n g M , X i n g Z M , L u C , M a Y X , Y u D L , Y a n Z , W a n g , S W , Y u L S . A c o m m o n I L - 1 3 A r g 1 3 0 G l n s i n g l e n u c l e o t i d e p o l y m o r p h i s m a m o n g C h i n e s e a t o p y p a t i e n t s w i t h a l l e r g i c r h i n i t i s . H u m G e n e t . 2 0 0 3 ; 1 1 3 ( 5 ) : 3 8 7 - 9 0 . P u b M e d P M I D : 1 2 9 2 8 8 6 1 . .
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H w a n g K C , W a n g J Y , H s i e h K H . I n c r e a s e d e r y t h r o c y t e a d e n o s i n e d e a m i n a s e a c t i v i t y i n a s t h m a t i c c h i l d r e n . Z h o n g h u a M i n G u o X i a o E r K e Y i X u e H u i Z a Z h i . 1 9 9 0 ; 3 1 ( 2 ) : 7 6 - 8 0 . P u b M e d P M I D : 2 2 7 5 3 6 9 . E p u b 1 9 9 0 / 0 3 / 0 1 . e n g . .
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L l o y d C M , H a w r y l o w i c z C M . R e g u l a t o r y T c e l l s i n a s t h m a . I m m u n i t y . 2 0 0 9 ; 3 1 ( 3 ) : 4 3 8 - 4 9 . P u b M e d P M I D : 1 9 7 6 6 0 8 6 . e n g . .
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R o b i n s o n D S . R e g u l a t o r y T c e l l s a n d a s t h m a . C l i n E x p A l l e r g y . 2 0 0 9 ; 3 9 ( 9 ) : 1 3 1 4 - 2 3 . P u b M e d P M I D : 1 9 5 3 8 4 9 6 . E p u b 2 0 0 9 / 0 6 / 2 3 . e n g . .
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C h e n T , H o u X , N i Y , D u W , H a n H , Y u Y , S h i G . T h e i m b a l a n c e o f F O X P 3 / G A T A 3 i n r e g u l a t o r y T c e l l s f r o m t h e p e r i p h e r a l b l o o d o f a s t h m a t i c p a t i e n t s . J I m m u n o l R e s . 2 0 1 8 ; 2 0 1 8 : 3 0 9 6 1 8 3 . P u b M e d P M I D : 3 0 0 1 3 9 8 9 . P u b m e d C e n t r a l P M C I D : P M C 6 0 2 2 3 3 6 . .
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O k a d a M , K a n a m o r i M , S o m e y a K , N a k a t s u k a s a H , Y o s h i m u r a A . S t a b i l i z a t i o n o f F o x p 3 e x p r e s s i o n b y C R I S - P R - d C a s 9 - b a s e d e p i g e n o m e e d i t i n g i n m o u s e p r i m a r y T c e l l s . E p i g e n e t i c s C h r o m a t i n . 2 0 1 7 ; 1 0 : 2 4 . P u b M e d P M I D : 2 8 5 0 3 2 0 2 . e n g . .
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A h m e d M S , D u t t a R K , M a n a n d h a r P , L i X , T o r a b i H , B a r r i o s A , W a n g P , C h i n n a p a i y a n S , U n w a l l a H J , M o o n J H . A g u a n y l u r e a - f u n c t i o n a l i z e d c o n j u g a t e d p o l y m e r e n a b l e s R N A i n t e r f e r e n c e i n e x v i v o h u m a n a i r w a y e p i t h e l i u m . C h e m C o m m u n ( C a m b ) . 2 0 1 9 ; 5 5 ( 5 4 ) : 7 8 0 4 - 7 . .
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K r i s h n a m u r t h y S , W o h l f o r d - L e n a n e C , K a n d i m a l l a S , S a r t r e G , M e y e r h o l z D K , T h e b e r g e V , H a l l e e S , D u p e r r e A M , D e l ' G u i d i c e T , L e p e t i t - S t o f f a e s J P , B a r b e a u X , G u a y D , M c C r a y P B J r . E n g i n e e r e d a m p h i p h i l i c p e p t i d e s e n a b l e d e l i v e r y o f p r o t e i n s a n d C R I S P R - a s s o c i a t e d n u c l e a s e s t o a i r w a y e p i t h e l i a . N a t C o m m u n . 2 0 1 9 ; 1 0 ( 1 ) : 4 9 0 6 . .
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Bolboli Zade Pedram, Farahani Abbas, Riyahi Mohammadreza, Lalabadi Ali, Salimi Asl Ali, Montazerghaem Sobhan, A Literature Review on Hospital-Acquired Pneumonia, Community-Acquired Pneumonia, and Ventilator-Associated Pneumonia, Gene, Cell and Tissue, 9, 2, 2021. Crossref