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Critical Reviews™ in Biomedical Engineering

Publicado 6 números por año

ISSN Imprimir: 0278-940X

ISSN En Línea: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

A Review of Technological Approaches to Venous Ulceration

Volumen 33, Edición 6, 2005, pp. 511-556
DOI: 10.1615/CritRevBiomedEng.v33.i6.10
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SINOPSIS

Leg ulceration is a chronic condition affecting about 1-2% of the adult population. The main causes of leg ulceration are venous hypertension, arterial insufficiency, diabetes, or a combination of these aetiologies (causes) or malignancy. Venous ulcers account for approximately 80% of all leg ulcers and are a result of venous hypertension. The current mainstay of treatment of venous ulcers is the application of graduated compression bandaging to the limb. In spite of the application of the best evidence-based therapy, healing rates for venous leg ulcers remain disappointing, at 50-70% after 12 weeks of treatment, depending on initial size and chronicity of the ulcer. Thus, a large number of ulcers are unhealed by this time, and many patients suffer from long-term leg ulceration, some remaining for years, and those that heal often recur. There is an obvious need to develop new treatments that would improve healing rates. This review provides a complete overview of the anatomy of venous circulation and the physiology pertaining to it, the pathophysiology of venous disease, the pathogenesis of ulceration, and a review of treatments currently employed in healing venous leg ulcers and their supporting evidence. The aim of this article is to encourage a fresh look at this chronic problem and stimulate ideas on how healing rates can be improved.

CITADO POR
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  2. Schmutz Jean-Luc, Meaume Sylvie, Fays Ségolène, Ourabah Zohva, Guillot Bernard, Thirion Valéne, Collier Mark, Barrett Simon, Smith J, Bohbot Serge, Dompmartin Anne, Evaluation of the nano-oligosaccharide factor lipido-colloid matrix in the local management of venous leg ulcers: results of a randomised, controlled trial, International Wound Journal, 5, 2, 2008. Crossref

  3. Kahn Steven Alexander, Beers Ryan J., Lentz Christopher W., Use of Acellular Dermal Replacement in Reconstruction of Nonhealing Lower Extremity Wounds, Journal of Burn Care & Research, 32, 1, 2011. Crossref

  4. Dong XiaoQing, Xu Jun, Wang WeiCai, Luo Hao, Liang XiaoFei, Zhang Lei, Wang HanJie, Wang PengHua, Chang Jin, Repair effect of diabetic ulcers with recombinant human epidermal growth factor loaded by sustained-release microspheres, Science in China Series C: Life Sciences, 51, 11, 2008. Crossref

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  6. O’Donnell Thomas F., Passman Marc A., Marston William A., Ennis William J., Dalsing Michael, Kistner Robert L., Lurie Fedor, Henke Peter K., Gloviczki Monika L., Eklöf Bo G., Stoughton Julianne, Raju Sesadri, Shortell Cynthia K., Raffetto Joseph D., Partsch Hugo, Pounds Lori C., Cummings Mary E., Gillespie David L., McLafferty Robert B., Murad Mohammad Hassan, Wakefield Thomas W., Gloviczki Peter, Management of venous leg ulcers: Clinical practice guidelines of the Society for Vascular Surgery® and the American Venous Forum, Journal of Vascular Surgery, 60, 2, 2014. Crossref

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  9. Mantilla Morato Teresa, Gomez de Celis Cornejo Maria Isabel, Paciente con úlceras vasculares y factores de riesgo cardiovascular, Enfermería Clínica, 17, 1, 2007. Crossref

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