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International Journal for Multiscale Computational Engineering

Publicado 6 números por año

ISSN Imprimir: 1543-1649

ISSN En Línea: 1940-4352

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.3 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 2.2 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00034 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.46 SJR: 0.333 SNIP: 0.606 CiteScore™:: 3.1 H-Index: 31

Indexed in

STOCHASTIC MODELING OF MACROMOLECULAR MOTIONS THROUGH POST ARRAYS

Volumen 11, Edición 4, 2013, pp. 347-358
DOI: 10.1615/IntJMultCompEng.2013005090
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SINOPSIS

The dynamic motions of macromolecules through a microfluidic postarray system are simulated using a three-dimensional stochastic finite element approach. The effects of molecular conformation on the time for a macromolecule to move across the system are investigated. The analyses are first performed on disklike geometries and then extended to a representative carbonic anhydrase (CA) macromolecule model consisting of elastically deformable beam networks. The model predicts that smaller molecules typically take less time to pass through the post array, and that for stiff materials the time inversely increases with the aspect ratio of molecules due to the conformational changes in collisions between the molecules and the obstacles. In addition, the dynamic responses of molecules are highly stochastic. The work has potential applications in designing functional microfluidic devices for separation and purification of macromolecules such as plasmid DNA.

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