Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 1.841 Factor de Impacto de 5 años: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v15.i1.40
pages 49-73

Nuclear Transport of Steroid Hormone Receptors

Leonard C. Shank
Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908
Bryce M. Paschal
Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908

SINOPSIS

Nuclear receptors (NRs) comprise a superfamily of ligand-regulated transcription factors implicated in a host of physiological processes, including development, differentiation, and proliferation. Translated in the cytoplasm, NRs must undergo import into the nucleus in order to modulate transcription of target genes in response to cognate hormones. NRs also undergo export from the nucleus, and there is emerging evidence that NR nucleocytoplasmic shuttling contributes to their regulation. Nucleocytoplasmic shuttling may provide a nexus for crosstalk between NRs and kinase pathways. Here we review some of the key studies on nuclear import and export of steroid hormone receptors within the NR superfamily, address some of the challenges in experimental dissection of NR transport and discuss recent findings linking specific kinase pathways to NR export.


Articles with similar content:

Coactivation and Corepression in Transcriptional Regulation by Steroid/Nuclear Hormone Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 2
J. Don Chen, Hui Li
CD28-CD80/86 and CD40-CD40L Interactions Promote Thymic Tolerance by Regulating Medullary Epithelial Cell and Thymocyte Development
Critical Reviews™ in Immunology, Vol.35, 2015, issue 1
Xuguang Tai , Richard J. Hodes, Joy A. Williams
Role of cAMP Phosphodiesterase 4 in Regulation of T-Cell Function
Critical Reviews™ in Immunology, Vol.26, 2006, issue 5
Kjetil Tasken, Elisa Bjorgo
Yin Yang 1 (YY1): Regulation of Survivin and Its Role In Invasion and Metastasis
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Nicholas R. Galloway, Kathryn F. Ball, Nathan R. Wall, TessaRae Stiff
The Cbl Family of Signal Transduction Molecules
Critical Reviews™ in Oncogenesis, Vol.8, 1997, issue 4
Linda Smit , Jannie Borst