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Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 1.841 Factor de Impacto de 5 años: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v7.i3.20
pages 215-230

Histone H1 and Chromatin Higher-Order Structure

V. Ramakrishnan
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132


The linker histone H1, or its variants such as H5, have long thought to be involved in promoting the organization of chromatin into a higher-order structure, the 30 nm filament. However, the location of H1 in the filament, its role in filament formation and the structure of the 30 nm filament itself have all been controversial. This article reviews recent results that address these questions.

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