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Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 1.841 Factor de Impacto de 5 años: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v7.i3.30
pages 231-240

Application of Atomic Force Microscopy to Visualization of DNA, Chromatin, and Chromosomes

Wolfgang Fritzsche
Department of Zoology and Genetics, Iowa State University, Ames, IA 50011
Lili Takac
Department of Ophthalmology, University Medical School, 4012 Debrecen, Hungary
Eric Henderson
Department of Zoology and Genetics, Iowa State University, Ames, IA 50011

SINOPSIS

The scanning force microscope (SFM, also called the atomic force microscope, AFM) provides a new and powerful method for visualization and manipulation of biological samples. Its high precision and sensitivity allow the investigator to interrogate samples at very high spatial resolution and simultaneously accumulate a variety of data types, including topography, viscoelasticity, chemical properties, and local friction. We provide here a brief review of the literature describing the current state of the art in the application of SFM to the study of DNA, chromatin and chromosomes, and some examples from this laboratory. Suggestions for future directions of this technology are also presented.


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