Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
Alterations in Cell Proliferation Related Gene Expressions in Gastric Cancer
SINOPSIS
Gastric cancer remains the fourth most prevalent cancer and the second leading cause of cancer-related death in the world. The predominant form of gastric cancer is adenocarcinoma, which originates from glandular epithelium of the gastric mucosa. The major risk factors for gastric cancer include diet, individual genetic variation, and, most importantly, infection with Helicobacter pylori (H. pylori). Certain strains of H. pylori assisted by some of its virulence factors seem to play a critical role in gastric cancer development. Several of these H. pylori virulence factors, which influence cellular proliferation signaling, have been identified. In addition, changes in the expression of several cell proliferation regulating genes accompany or cause the progression of gastric cancer. These changes include modifications of cell cycle regulators, oncogene activation, tumor suppressor inactivation, and miRNA profile alterations. Many of these changes result from H. pylori infection, although their impact on the cellular proliferation system underlying gastric cancer development has not yet been fully elucidated. We review certain features of gastric cancer, the role of H. pylori infection in its etiology and pathogenesis, and gene expression changes during gastric carcinogenesis.
-
Li Kang, Xia Fan, Zhang Kai, Mo Anwei, Liu Li, Association of a Tgf-B1-509c/T Polymorphism with Gastric Cancer Risk: A Meta-Analysis, Annals of Human Genetics, 77, 1, 2013. Crossref
-
Tong Fuyi, Cao Peng, Yin Yuan, Xia Suhua, Lai Rensheng, Liu Shenlin, MicroRNAs in Gastric Cancer: From Benchtop to Bedside, Digestive Diseases and Sciences, 59, 1, 2014. Crossref
-
Chang Wei-wei, Zhang Liu, Su Hong, Yao Ying-shui, An updated meta-analysis of transforming growth factor-β1 gene: three polymorphisms with gastric cancer, Tumor Biology, 35, 4, 2014. Crossref
-
Mai Cong, Zhao Jing-jing, Tang Xiao-feng, Wang Wei, Pan Ke, Pan Qiu-zhong, Zhang Xiao-fei, Jiang Shan-shan, Zhao Bai-wei, Li Yuan-fang, Xia Jian-chuan, Zhou Zhi-wei, Decreased ITIH5 expression is associated with poor prognosis in primary gastric cancer, Medical Oncology, 31, 7, 2014. Crossref
-
Wu Jian-Hong, Yao Yong-Liang, Gu Tao, Wang Ze-You, Pu Xiong-Yong, Sun Wang-Wei, Zhang Xian, Jiang Yi-Biao, Wang Jian-Jun, MiR-421 Regulates Apoptosis of BGC-823 Gastric Cancer Cells by Targeting Caspase-3, Asian Pacific Journal of Cancer Prevention, 15, 13, 2014. Crossref
-
Lee Hyun-Woo, Jang Kenny Seung Bin, Choi Hye Ji, Jo Ara, Cheong Jae-Ho, Chun Kyung-Hee, Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy, BMB Reports, 47, 12, 2014. Crossref
-
Chen Wei-Qiang, Xu Bin, Mao Jian-Wen, Wei Feng-Xiang, Li Ming, Liu Tao, Jin Xiao-Bao, Zhang Li-Rong, Inhibitory Effects of α-Pinene on Hepatoma Carcinoma Cell Proliferation, Asian Pacific Journal of Cancer Prevention, 15, 7, 2014. Crossref
-
Huang Haitao, Chen Zhiqi, Ni Xiuqin, Tissue transglutaminase-1 promotes stemness and chemoresistance in gastric cancer cells by regulating Wnt/β-catenin signaling, Experimental Biology and Medicine, 242, 2, 2017. Crossref
-
Liao Juan, Wen Shichao, Cao Lipeng, Zhou Yunfeng, Feng Zhisong, Saraiva Ligia M, Effect of Eradication of Helicobacter pylori on Expression Levels of FHIT, IL-8 and P73 in Gastric Mucosa of First-Degree Relatives of Gastric Cancer Patients, PLOS ONE, 10, 4, 2015. Crossref
-
Yu Junyan, Tian Xiangyang, Chang Jianlan, Liu Ping, Zhang Rong, RUNX3 inhibits the proliferation and metastasis of gastric cancer through regulating miR-182/HOXA9, Biomedicine & Pharmacotherapy, 96, 2017. Crossref
-
Zhao L Y, Tong D D, Xue M, Ma H L, Liu S Y, Yang J, Liu Y X, Guo B, Ni L, Liu L Y, Qin Y N, Wang L M, Zhao X G, Huang C, MeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1/2–ERK1/2 signaling pathway by upregulating GIT1, Oncogenesis, 6, 7, 2017. Crossref
-
WEI BIN, SONG YING, ZHANG YONGHONG, HU MINGJUN, microRNA-449a functions as a tumor-suppressor in gastric adenocarcinoma by targeting Bcl-2, Oncology Letters, 6, 6, 2013. Crossref
-
Guo Dandan, Zhang Wei, Yang Haijie, Bi Jiajia, Xie Yunfei, Cheng Binfeng, Wang Yan, Chen Sujuan, Celastrol Induces Necroptosis and Ameliorates Inflammation via Targeting Biglycan in Human Gastric Carcinoma, International Journal of Molecular Sciences, 20, 22, 2019. Crossref
-
Zhou Yangchun, Wang Yao, Wen Jianfei, Zhao Haijian, Dong Xuqiang, Zhang Zhihong, Wang Shoulin, Shen Lizong, Aquaporin 3 promotes the stem-like properties of gastric cancer cells via Wnt/GSK-3β/β-catenin pathway, Oncotarget, 7, 13, 2016. Crossref
-
Zhu Tong, Hu Xueqian, Wei Pinkang, Shan Guangzhi, Molecular background of the regional lymph node metastasis of gastric cancer (Review), Oncology Letters, 2018. Crossref
-
Chen Na, Han Xiangdong, Yin Bo, Bai Xue, Wang Yubin, FGD5 facilitates tumor growth by regulating EGFR ubiquitination in gastric cancer, Biochemical and Biophysical Research Communications, 562, 2021. Crossref
-
Xie Biao, Zhou Jianping, Shu Guoshun, Liu Dong-cai, Zhou Jiapeng, Chen Jinhui, Yuan Lianwen, Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer, Cancer Cell International, 13, 1, 2013. Crossref
-
Matsuo Teppei, Nishizuka Satoshi S, Ishida Kazushige, Endo Fumitaka, Katagiri Hirokatsu, Kume Kohei, Ikeda Miyuki, Koeda Keisuke, Wakabayashi Go, Evaluation of chemosensitivity prediction using quantitative dose–response curve classification for highly advanced/relapsed gastric cancer, World Journal of Surgical Oncology, 11, 1, 2013. Crossref
-
Deng Chaowei, Zhang Lu, Ma Xiaoping, Cai Shuang, Jia Yuzhen, Zhao Lingyu, RFTN1 facilitates gastric cancer progression by modulating AKT/p38 signaling pathways, Pathology - Research and Practice, 234, 2022. Crossref
-
Mohamed Waleed A., Schaalan Mona F., Ramadan Basma, The expression profiling of circulating miR‐204, miR‐182, and lncRNA H19 as novel potential biomarkers for the progression of peptic ulcer to gastric cancer, Journal of Cellular Biochemistry, 120, 8, 2019. Crossref
-
Cao Longlong, Zhou Jiechao, Zhang Junrong, Wu Sijin, Yang Xintao, Zhao Xin, Li Huifang, Luo Ming, Yu Qian, Lin Guangtan, Lin Huizhong, Xie Jianwei, Li Ping, Hu Xiaoqing, Zheng Chaohui, Bu Guojun, Zhang Yun-wu, Xu Huaxi, Yang Yongliang, Huang Changming, Zhang Jie, Cyclin-Dependent Kinase 5 Decreases in Gastric Cancer and Its Nuclear Accumulation Suppresses Gastric Tumorigenesis, Clinical Cancer Research, 21, 6, 2015. Crossref